Alternative Splicing of Fibroblast Growth Factor Receptor 3 Produces a Secreted Isoform That Inhibits Fibroblast Growth Factor–Induced Proliferation and Is Repressed in Urothelial Carcinoma Cell Lines

Purpose: This report aims to describe a case of bilateral, multifocal neurosensory retinal detachments that developed during erdafitinib therapy for metastatic urothelial carcinoma. Methods: A case report with color fundus imaging and spectral-domain optical coherence tomography imaging is presented. Results: A 50-year-old man with metastatic urothelial carcinoma had an unremarkable baseline ophthalmic examination prior to starting erdafitinib. At 3-month follow up, an examination revealed bilateral, multifocal retinal detachments. Because the patient was asymptomatic and erdafitinib was the only drug to which his tumor had responded, he was kept on the medication with close ophthalmic monitoring. Conclusions: Erdafitinib, a fibroblast growth factor receptor inhibitor, can cause bilateral, multifocal retinal detachments. Continuation of erdafitinib may be considered in patients without significant visual impairment when the overall benefit of the medication appears to outweigh the risks.

Download Full-text

Enhanced Expression of Fibroblast Growth Factor Receptor 3 IIIc Promotes Human Esophageal Carcinoma Cell Proliferation

Journal of Histochemistry & Cytochemistry ◽

10.1369/0022155415616161 ◽

2015 ◽

Vol 64 (1) ◽

pp. 7-17 ◽

Cited By ~ 5

Author(s):

Nobuhiro Ueno ◽

Akio Shimizu ◽

Michiyuki Kanai ◽

Yugo Iwaya ◽

Shugo Ueda ◽

...

Keyword(s):

Cell Proliferation ◽

Growth Factor ◽

Esophageal Carcinoma ◽

Fibroblast Growth Factor ◽

Fibroblast Growth Factor Receptor ◽

Carcinoma Cell ◽

Growth Factor Receptor ◽

Fibroblast Growth ◽

Enhanced Expression

Download Full-text

Control of BEK and K-SAM splice sites in alternative splicing of the fibroblast growth factor receptor 2 pre-mRNA

Molecular and Cellular Biology ◽

10.1128/mcb.13.9.5461-5468.1993 ◽

1993 ◽

Vol 13 (9) ◽

pp. 5461-5468

Author(s):

E Gilbert ◽

F Del Gatto ◽

P Champion-Arnaud ◽

M C Gesnel ◽

R Breathnach

Keyword(s):

Alternative Splicing ◽

Growth Factor ◽

Fibroblast Growth Factor ◽

Fibroblast Growth Factor Receptor ◽

Growth Factor Receptor ◽

Fibroblast Growth ◽

Splice Sites ◽

Polypyrimidine Tract ◽

Profound Influence ◽

In Cells

The fibroblast growth factor receptor 2 gene pre-mRNA can be spliced by using either the K-SAM exon or the BEK exon. The exon chosen has a profound influence on the ligand-binding specificity of the receptor obtained. Cells make a choice between the two alternative exons by controlling use of both exons. Using fibroblast growth factor receptor 2 minigenes, we have shown that in cells normally using the K-SAM exon, the BEK exon is not used efficiently even in the absence of the K-SAM exon. This is because these cells apparently express a titratable repressor of BEK exon use. In cells normally using the BEK exon, the K-SAM exon is not used efficiently even in the absence of a functional BEK exon. Three purines in the K-SAM polypyrimidine tract are at least in part responsible for this, as their mutation to pyrimidines leads to efficient use of the K-SAM exon, while mutating the BEK polypyrimidine tract to include these purines stops BEK exon use.

Download Full-text