scholarly journals Activator Protein-2 Overexpression Accounts for Increased Insulin Receptor Expression in Human Breast Cancer

2006 ◽  
Vol 66 (10) ◽  
pp. 5085-5093 ◽  
Author(s):  
Francesco Paonessa ◽  
Daniela Foti ◽  
Vanessa Costa ◽  
Eusebio Chiefari ◽  
Giuseppe Brunetti ◽  
...  
2000 ◽  
Vol 196 (11) ◽  
pp. 753-759 ◽  
Author(s):  
Georg Wolf ◽  
Ralf Hildenbrand ◽  
Christian Schwar ◽  
Rainer Grobholz ◽  
Manfred Kaufmann ◽  
...  

2009 ◽  
Vol 175 (1) ◽  
pp. 334-341 ◽  
Author(s):  
Janna Paulsson ◽  
Tobias Sjöblom ◽  
Patrick Micke ◽  
Fredrik Pontén ◽  
Göran Landberg ◽  
...  

2015 ◽  
Vol 14 (2) ◽  
pp. 190-195
Author(s):  
Nikoo Khannazer ◽  
Seyed Hassan Paylakhi ◽  
Abbas Mirshafiey ◽  
Gholamreza Azizi ◽  
Nasrin Motamed

Introduction: Silibinin, a polyphenolic flavonoid isolated from the milk thistle plant (Silybummarianum), has various applications in cancer therapy. This investigation aimed to examine the effects of silibinin on proliferation and chemokine receptor expression on MDA-MB-231 cells, a highly metastatic human breast cancer cell line.Methods: The cytotoxic effect of silibinin on MDA-MB-231 cells was determined by micro-culture tetrazolium test (MTT) assay. In addition, the expression of chemokine receptors CXCR3, CCR5 and CCR7 genes in response to silibinin was evaluated by Real-Time PCR.Results: Data analysis from MTT assay showed that silibinin had dose-dependent and time-dependent inhibitory effects on MDA-MB-231 cell line. Moreover, Real-Time PCR analysis showed that silibinin not only had no inhibitory effects on CXCR3, CCR5 and CCR7 gene expressions, but also could increase significantly the expression of these genes in a dose and time-dependent manner.Conclusion: These results revealed for the first time the increased possibility of CXCR3, CCR5 and CCR7 genes expression in response to silibinin in human breast cancer cells.Bangladesh Journal of Medical Science Vol.14(2) 2015 p.190-195


2016 ◽  
Vol 24 (4) ◽  
pp. 238-245 ◽  
Author(s):  
Ibrahim Y. Hachim ◽  
Mahmood Y. Hachim ◽  
Vanessa M. Lopez ◽  
Jean-Jacques Lebrun ◽  
Suhad Ali

1995 ◽  
Vol 2 (4) ◽  
pp. 281-292
Author(s):  
A H Bootsma ◽  
C H J van Eijck ◽  
L J Hofland ◽  
S W J Lamberts

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