Mouse Models of Pediatric Supratentorial High-grade Glioma Reveal How Cell-of-Origin Influences Tumor Development and Phenotype

2016 ◽  
Vol 77 (3) ◽  
pp. 802-812 ◽  
Author(s):  
Smitha Sreedharan ◽  
Naga Prathyusha Maturi ◽  
Yuan Xie ◽  
Anders Sundström ◽  
Malin Jarvius ◽  
...  
Keyword(s):  
Mouse Models ◽  
Tumor Development ◽  
High Grade Glioma ◽  
High Grade ◽  
Cell Of Origin

High-grade glioma mouse models and their applicability for preclinical testing

2009 ◽  
Vol 35 (8) ◽  
pp. 714-723 ◽  
Author(s):  
Nienke A. de Vries ◽  
Jos H. Beijnen ◽  
Olaf van Tellingen
Keyword(s):  
Mouse Models ◽  
High Grade Glioma ◽  
High Grade ◽  
Preclinical Testing

scholarly journals Integrated Molecular Profiling Studies to Characterize the Cellular Origins of High-Grade Serous Ovarian Cancer

2018 ◽  
Author(s):  
Kate Lawrenson ◽  
Marcos A.S. Fonseca ◽  
Felipe Segato ◽  
Janet M. Lee ◽  
Rosario I. Corona ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Cells ◽  
Tumor Development ◽  
Molecular Profiling ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Cell Of Origin ◽  
Ovarian Cancers ◽  
Integrative Analyses ◽  
Ovarian Surface Epithelial

AbstractHistorically, high-grade serous ovarian cancers (HGSOCs) were thought to arise from ovarian surface epithelial cells (OSECs) but recent data implicate fallopian tube secretory epithelial cells (FTSECs) as the major precursor. We performed transcriptomic and epigenomic profiling to characterize molecular similarities between OSECs, FTSECs and HGSOCs. Transcriptomic signatures of FTSECs were preserved in most HGSOCs reinforcing FTSECs as the predominant cell-of-origin; though an OSEC-like signature was associated with increased chemosensitivity (Padj= 0.03) and was enriched in proliferative-type tumors, suggesting a dualistic model for HGSOC origins. More super-enhancers (SEs) were shared between FTSECs and HGSOCs than between OSECS and HGSOCs (P< 2.2 × 10−16). SOX18, ELF3 and EHF transcription factors (TFs) coincided with HGSOC SEs and represent putative novel drivers of tumor development. Our integrative analyses support a predominantly fallopian origin for HGSOCs and indicate tumorigenesis may be driven by different TFs according to cell-of-origin.

scholarly journals PI3K–mTOR Pathway Inhibition Exhibits Efficacy Against High-grade Glioma in Clinically Relevant Mouse Models

2016 ◽  
Vol 23 (5) ◽  
pp. 1286-1298 ◽  
Author(s):  
Fan Lin ◽  
Mark C. de Gooijer ◽  
Diana Hanekamp ◽  
Gayathri Chandrasekaran ◽  
Levi C.M. Buil ◽  
...  
Keyword(s):  
Mouse Models ◽  
High Grade Glioma ◽  
Mtor Pathway ◽  
High Grade ◽  
Pathway Inhibition

scholarly journals Comparative study of preclinical mouse models of high-grade glioma for nanomedicine research: the importance of reproducing blood-brain barrier heterogeneity

Theranostics ◽  
2020 ◽  
Vol 10 (14) ◽  
pp. 6361-6371 ◽  
Author(s):  
Caterina Brighi ◽  
Lee Reid ◽  
Laura A Genovesi ◽  
Marija Kojic ◽  
Amanda Millar ◽  
...  
Keyword(s):  
Comparative Study ◽  
Blood Brain Barrier ◽  
Mouse Models ◽  
High Grade Glioma ◽  
Brain Barrier ◽  
High Grade ◽  
Blood Brain

scholarly journals Self-Renewal Does Not Predict Tumor Growth Potential in Mouse Models of High-Grade Glioma

Cancer Cell ◽  
2012 ◽  
Vol 21 (1) ◽  
pp. 11-24 ◽  
Author(s):  
Lindy E. Barrett ◽  
Zvi Granot ◽  
Courtney Coker ◽  
Antonio Iavarone ◽  
Dolores Hambardzumyan ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Mouse Models ◽  
High Grade Glioma ◽  
Growth Potential ◽  
High Grade ◽  
Self Renewal

scholarly journals Rapid and Robust Transgenic High-Grade Glioma Mouse Models for Therapy Intervention Studies

2010 ◽  
Vol 16 (13) ◽  
pp. 3431-3441 ◽  
Author(s):  
Nienke A. de Vries ◽  
Sophia W. Bruggeman ◽  
Danielle Hulsman ◽  
Hilda I. de Vries ◽  
John Zevenhoven ◽  
...  
Keyword(s):  
Mouse Models ◽  
Intervention Studies ◽  
High Grade Glioma ◽  
High Grade ◽  
Therapy Intervention

scholarly journals Cell of Origin Determines Tumor Phenotype in an Oncogenic Ras/p53 Knockout Transgenic Model of High-Grade Glioma

2012 ◽  
Vol 71 (8) ◽  
pp. 729-740 ◽  
Author(s):  
Sabah O. Ghazi ◽  
Michelle Stark ◽  
Zhiguo Zhao ◽  
Bret C. Mobley ◽  
Alex Munden ◽  
...  
Keyword(s):  
High Grade Glioma ◽  
High Grade ◽  
Cell Of Origin ◽  
Transgenic Model ◽  
Oncogenic Ras ◽  
Tumor Phenotype
Sign in / Sign up

Export Citation Format

Share Document