scholarly journals MYC- and MIZ1-dependent vesicular transport of double-strand RNA controls immune evasion in pancreatic ductal adenocarcinoma

2021 ◽  
pp. canres.CAN-21-1677-E.2021
Author(s):  
Bastian Krenz ◽  
Anneli Gebhardt-Wolf ◽  
Carsten P Ade ◽  
Abdallah Gaballa ◽  
Florian Roehrig ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Immune Evasion ◽  
Vesicular Transport ◽  
Ductal Adenocarcinoma

scholarly journals Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression

2022 ◽  
Vol 13 (1) ◽  
Author(s):  
Phyllis F. Cheung ◽  
JiaJin Yang ◽  
Rui Fang ◽  
Arianna Borgers ◽  
Kirsten Krengel ◽  
...  
Keyword(s):  
Overall Survival ◽  
T Cell ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Mhc Class I ◽  
Immune Evasion ◽  
Ductal Adenocarcinoma ◽  
Poor Overall Survival ◽  
T Cell Infiltration ◽  
Cancer Initiation ◽  
Underlying Mechanisms

AbstractImmune evasion is indispensable for cancer initiation and progression, although its underlying mechanisms in pancreatic ductal adenocarcinoma (PDAC) are not fully known. Here, we characterize the function of tumor-derived PGRN in promoting immune evasion in primary PDAC. Tumor- but not macrophage-derived PGRN is associated with poor overall survival in PDAC. Multiplex immunohistochemistry shows low MHC class I (MHCI) expression and lack of CD8+ T cell infiltration in PGRN-high tumors. Inhibition of PGRN abrogates autophagy-dependent MHCI degradation and restores MHCI expression on PDAC cells. Antibody-based blockade of PGRN in a PDAC mouse model remarkably decelerates tumor initiation and progression. Notably, tumors expressing LCMV-gp33 as a model antigen are sensitized to gp33-TCR transgenic T cell-mediated cytotoxicity upon PGRN blockade. Overall, our study shows a crucial function of tumor-derived PGRN in regulating immunogenicity of primary PDAC.

Clinical significance of cathepsin E in pancreatic juice in the diagnosis of pancreatic ductal adenocarcinoma

2000 ◽  
Vol 15 (11) ◽  
pp. 1333-1338 ◽  
Author(s):  
Koji Uno ◽  
Takeshi Azuma ◽  
Masatsugu Nakajima ◽  
Kenjiro Yasuda ◽  
Takanobu Hayakumo ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Clinical Significance ◽  
Pancreatic Juice ◽  
Ductal Adenocarcinoma ◽  
Cathepsin E
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