Abstract P3-10-41: Quantitative Immunohistochemical Analysis and Prognostic Significance of TRPS-1, a New GATA Transcription Factor Family Member, in Breast Cancer

2010 ◽  
Author(s):  
JQ Chen ◽  
J Litton ◽  
L Xiao ◽  
H-Z Zhang ◽  
CL Warneke ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Transcription Factor ◽  
Family Member ◽  
Prognostic Significance ◽  
Immunohistochemical Analysis ◽  
Transcription Factor Family ◽  
Gata Transcription Factor

Active c-Src has prognostic and therapeutic value in ER-negative breast cancer

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 10063-10063
Author(s):  
A. Arnaout ◽  
L. Yang ◽  
C. Holloway ◽  
N. Steven ◽  
P. Sun ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Significance ◽  
Immunohistochemical Analysis ◽  
Tissue Microarrays ◽  
Distant Recurrence ◽  
Breast Cancers ◽  
Nonreceptor Tyrosine Kinase ◽  
Human Breast Carcinomas ◽  
Er Positive ◽  
Er Status

10063 Background: Approximately 33% of newly diagnosed breast cancers lack ER and these tend to have a worse prognosis as compared to ER-positive breast cancers. Therapeutic options are limited as they are not responsive to antihormonal therapy and often develop resistance to chemotherapies. We have recently shown that activation of the nonreceptor tyrosine kinase protein c-Src leads to the accelerated ER degradation in ER-negative breast cancers. This study performs an immunohistochemical analysis of activated c-Src in a large cohort of primary human breast carcinomas to a) assess its prognostic significance and b) correlate its relationship to the ER status of breast cancers. Methods: A total of 916 patients with breast cancer diagnosed between 1987 and 1997 had clinicopathological data and paraffin-embedded tumor tissues for the study. Tissue microarrays were constructed. A four point scoring system based on immunostaining intensity was used to grade the levels of active phosphorylated c-Src. Grading was done by one pathologist. Statistical analysis was used to assess the prognostic significance of activated c-Src and its relationship to other prognostic variables. Results: Median follow-up was 7.31 years. Active c-Src grade was inversely correlated with ER status (p=0.004) and predicted for treatment with chemotherapy (p=0.002) and lack of treatment with Tamoxifen (p=0.007). Patients with greater levels of c-Src tended to be younger (p=0.004) and had higher Bloom Richardson scores for their tumors (p=0.004). Higher levels of c-Src also predicted for for shorter timing to distant recurrence (p=0.01) and shorter timing to death (p=0.04). There was a trend towards a shorter timing to regional recurrence with higher levels of c-Src but the relationship was not statistically significant (p=0.08). Conclusion: This study supports the hypothesis that the presence of active, phosphorylated c-Src contributes to the development of ER-negative status in breast cancers. The presence of c-Src also is associated with other poor prognostic factors and contributes to a worse prognostic outcome. This study suggests that c-Src inhibitors may be a novel therapeutic strategy for the treatment of ER-negative breast cancers. No significant financial relationships to disclose.

412 Expression of the Ets transcription factor family in HER2/neu positive breast cancer

2003 ◽  
Vol 1 (5) ◽  
pp. S126
Author(s):  
E. Myers ◽  
A.D.K. Hill ◽  
Y. Buggy ◽  
E.W. Mc Dermott ◽  
N.J. O'Higgins ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Transcription Factor ◽  
Transcription Factor Family ◽  
Ets Transcription Factor ◽  
Positive Breast Cancer

scholarly journals Impacts of a new transcription factor family

2004 ◽  
Vol 166 (6) ◽  
pp. 765-768 ◽  
Author(s):  
Said Hashemolhosseini ◽  
Michael Wegner
Keyword(s):  
Transcription Factor ◽  
Drosophila Melanogaster ◽  
Dna Binding ◽  
Family Member ◽  
Parathyroid Gland ◽  
Dna Binding Domain ◽  
Transcription Factor Family ◽  
Master Regulators ◽  
Zinc Cations

GCM proteins constitute a small transcription factor family with a DNA-binding domain exhibiting a novel fold composed of two subdomains rigidly held together by coordination of one of two structural zinc cations. In all known cases, GCM proteins exert the role of master regulators: the prototypical family member determines gliogenesis in Drosophila melanogaster, whereas mammalian GCM proteins orchestrate divergent aspects of development and physiology in placenta, kidney, thymus, and parathyroid gland. Recent data point to an involvement of GCM proteins in different pathological contexts, such as preeclampsia, hyper- or hypoparathyroidism, and parathyroid gland tumors.

scholarly journals Distinct Expression and Prognostic Values of GATA Transcription Factor Family in Human Ovarian Cancer.

2020 ◽  
Author(s):  
Quan Zhou ◽  
Yang Huai-jie ◽  
Zuo Man-Zhen ◽  
Ya-ling Tao
Keyword(s):  
Ovarian Cancer ◽  
Transcription Factor ◽  
Signaling Pathway ◽  
Expression Patterns ◽  
Notch Signaling Pathway ◽  
Human Ovarian Cancer ◽  
Hippo Signaling ◽  
Transcription Factor Family ◽  
Kaplan Meier ◽  
Gata Transcription Factor

Abstract Accumulated studies have provided controversial evidences of expression patterns and prognostic value of the GATA transcription factor family in human ovarian cancer. In the present study, we accessed the distinct expression and prognostic roles of 7 individual members of GATA family in ovarian cancer (OC) patients through Oncoming analysis, CCLE analysis, the Kaplan–Meier plotter (KM plotter) database, cBioPortal and Metascape. Our results indicated that GATA1, GATA3, GATA4 and TRPS1 mRNA expression was significantly higher in OC than normal samples. High expression of GATA1, GATA2, and GATA4 were significantly correlated with better overall survival (OS), while increased GATA3 and GATA6 expression were associated with worse prognosis in OC patients. GATA1, GATA2, GATA3 and GATA6 were closely related to the different clinicopathological features of OC. The genetic variation and interaction of the GATA family may be closely related to the pathogenesis and prognosis of OC, and the regulatory network composed of GATA family genes and their neighboring genes are mainly involved in Notch signaling pathway, Th1 and Th2 cell differentiation and Hippo signaling pathway. Our results might be beneficial for the better understanding of heterogeneity and complexity in the molecular biology of ovarian cancer, and paving a way for more accurate prediction of the prognosis of patients with OC.

TP73 DNA methylation and upregulation of ΔNp73 are associated with an adverse prognosis in breast cancer

2017 ◽  
Vol 71 (1) ◽  
pp. 52-58 ◽  
Author(s):  
Laura C Gomez ◽  
Mayra L Sottile ◽  
Martin E Guerrero-Gimenez ◽  
Felipe C M Zoppino ◽  
Analia L Redondo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Histological Grade ◽  
Methylation Status ◽  
Prognostic Significance ◽  
Inverse Correlation ◽  
Positive Association ◽  
Immunohistochemical Analysis ◽  
Aberrant Methylation ◽  
Breast Cancer Patients

AimAccumulated evidence suggests that aberrant methylation of the TP73 gene and increased levels of ΔNp73 in primary tumours correlate with poor prognosis. However, little is known regarding the transcriptional and functional regulation of the TP73 gene in breast cancer. The aim of the present study was to determine the expression of the ΔNp73 isoform, its relationship with DNA methylation of TP73 and their clinical prognostic significance in breast cancer patients.MethodsTP73 gene methylation was studied in TCGA datasets and in 70 invasive ductal breast carcinomas (IDCs). The expression of p73 isoforms was evaluated by immunohistochemistry (IHC) and Western blot and correlated with clinicopathological variables and clinical outcome.ResultsWe observed that the methylation of diverse CpG islands of TP73 differed significantly between molecular subtypes. An inverse correlation was found between p73 protein expression and the methylation status of the TP73 gene. The expression of exon 3’ of p73 (only expressed in ΔNp73) was significantly higher in patients with wild-type p53. Immunohistochemical analysis revealed that all p73 isoforms were localised in both the nuclear and cytoplasmic compartments. We confirmed a positive association between the expression of ∆Np73 and high histological grade.ConclusionsOur findings suggest that high expression of ΔNp73 could be used to determine the aggressiveness of IDCs and could be incorporated in the pathologist’s report.

scholarly journals PPARδas a Metabolic Initiator of Mammary Neoplasia and Immune Tolerance

PPAR Research ◽  
2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Robert I. Glazer
Keyword(s):  
Breast Cancer ◽  
Transcription Factor ◽  
Nuclear Receptor ◽  
Immune Tolerance ◽  
Mammary Epithelium ◽  
Specific Context ◽  
Transcription Factor Family ◽  
Tissue Specific ◽  
Mammary Neoplasia

PPARδis a ligand-activated nuclear receptor that regulates the transcription of genes associated with proliferation, metabolism, inflammation, and immunity. Within this transcription factor family, PPARδis unique in that it initiates oncogenesis in a metabolic and tissue-specific context, especially in mammary epithelium, and can regulate autoimmunity in some tissues. This review discusses its role in these processes and how it ultimately impacts breast cancer.

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