scholarly journals Large-Scale Evaluation of Genetic Variants in Candidate Genes for Colorectal Cancer Risk in the Nurses' Health Study and the Health Professionals' Follow-up Study

2008 ◽  
Vol 17 (2) ◽  
pp. 311-319 ◽  
Author(s):  
Aditi Hazra ◽  
Stephen Chanock ◽  
Edward Giovannucci ◽  
David G. Cox ◽  
Tianhua Niu ◽  
...  
2016 ◽  
Vol 139 (5) ◽  
pp. 996-1008 ◽  
Author(s):  
Yeong Sook Yoon ◽  
Seungyoun Jung ◽  
Xuehong Zhang ◽  
Shuji Ogino ◽  
Edward L. Giovannucci ◽  
...  

2018 ◽  
Vol 108 (5) ◽  
pp. 1092-1103 ◽  
Author(s):  
Joshua Petimar ◽  
Stephanie A Smith-Warner ◽  
Teresa T Fung ◽  
Bernard Rosner ◽  
Andrew T Chan ◽  
...  

ABSTRACT Background Many dietary indexes exist for chronic disease prevention, but the optimal dietary pattern for colorectal cancer prevention is unknown. Objective We sought to determine associations between adherence to various dietary indexes and incident colorectal cancer in 2 prospective cohort studies. Design We followed 78,012 women in the Nurses’ Health Study and 46,695 men in the Health Professionals Follow-up Study from 1986 and 1988, respectively, until 2012. We created dietary index scores for the Dietary Approaches to Stop Hypertension (DASH) diet, Alternative Mediterranean Diet (AMED), and Alternative Healthy Eating Index-2010 (AHEI-2010) and used Cox regression to estimate HRs and 95% CIs for risk of colorectal cancer (CRC) and by anatomic subsite. We also conducted latency analyses to examine associations between diet and CRC risk during different windows of exposure. We conducted analyses in men and women separately, and subsequently pooled these results in a random-effects meta-analysis. Results We documented 2690 colorectal cancer cases. Pooled multivariable HRs for colorectal cancer risk comparing the highest to lowest quintile of diet scores were 0.89 (95% CI: 0.74, 1.08; P-trend = 0.10) for DASH, 0.89 (95% CI: 0.73, 1.10; P-trend = 0.31) for AMED, and 0.95 (95% CI: 0.83, 1.09; P-trend = 0.56) for AHEI-2010 (P-heterogeneity ≥ 0.07 for all). In sex-specific analyses, we observed stronger associations in men for all dietary indexes (DASH: multivariable HR = 0.81, 95% CI: 0.66, 0.98; P-trend = 0.003; AMED: multivariable HR = 0.80, 95% CI: 0.65, 0.98; P-trend = 0.02; AHEI-2010: multivariable HR = 0.88, 95% CI: 0.72, 1.07; P-trend = 0.04) than in women (multivariable HRs range from 0.98 to 1.01). Conclusions Adherence to the DASH, AMED, and AHEI-2010 diets was inversely associated with colorectal cancer risk in men. These diets were not associated with colorectal cancer risk in women. This observational study was registered at http://www.clinicaltrials.gov as NCT03364582.


2016 ◽  
Vol 139 (10) ◽  
pp. 2232-2242 ◽  
Author(s):  
Xuehong Zhang ◽  
NaNa Keum ◽  
Kana Wu ◽  
Stephanie A. Smith-Warner ◽  
Shuji Ogino ◽  
...  

2016 ◽  
Vol 124 (10) ◽  
pp. 1529-1536 ◽  
Author(s):  
Ngoan Tran Le ◽  
Fernanda Alessandra Silva Michels ◽  
Mingyang Song ◽  
Xuehong Zhang ◽  
Adam M. Bernstein ◽  
...  

2016 ◽  
Vol 139 (9) ◽  
pp. 1949-1957 ◽  
Author(s):  
Elizabeth D. Kantor ◽  
Xuehong Zhang ◽  
Kana Wu ◽  
Lisa B. Signorello ◽  
Andrew T. Chan ◽  
...  

2015 ◽  
Vol 8 (7) ◽  
pp. 620-627 ◽  
Author(s):  
Mingyang Song ◽  
Frank B. Hu ◽  
Donna Spiegelman ◽  
Andrew T. Chan ◽  
Kana Wu ◽  
...  

2010 ◽  
Vol 21 (8) ◽  
pp. 1315-1321 ◽  
Author(s):  
Rania A. Mekary ◽  
Kana Wu ◽  
Edward Giovannucci ◽  
Laura Sampson ◽  
Charles Fuchs ◽  
...  

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