Daily Physical Activity and Symptom Reporting in Breast Cancer Patients Undergoing Chemotherapy: An Intensive Longitudinal Examination

Abstract Introduction Physical activity may reduce the development of breast cancer. Whereas hypercoagulability has been linked to adverse outcomes in breast cancer patients, the effects of physical activity on their hemostatic factors are unknown. The study aimed to assess whether long-term (1 year) physical activity can affect hemostatic factors in breast cancer patients. Methods Fifty-five women (35–75 years) with invasive breast cancer stage I/II were randomized to a physical activity intervention (n = 29) lasting 1 year or to a control group (n = 26), and analyzed as intention to treat. Fibrinogen, factor VII antigen, tissue factor pathway inhibitor, and von Willebrand factor (VWF) antigen as well as prothrombin fragment 1 + 2, the endogenous thrombin potential and D-dimer, were measured in plasma before intervention (baseline), and then after 6 and 12 months. Results Maximal oxygen uptake (measure of cardiorespiratory fitness) decreased the first 6 months among the controls, but remained stable in the intervention group. We found no significant differences between the two study groups regarding any of the hemostatic factors, except a significantly higher increase in factor VII antigen in the intervention group. The effect of the intervention on VWF was, however, significantly affected by menopausal stage, and a significant effect of the intervention was found on VWF among postmenopausal women, even after adjustment for dietary intake. Conclusion Long-term physical activity had no effect on the majority of the hemostatic factors measured, but led to increased plasma concentrations of factor VII antigen and prevented an increase in VWF concentration after breast cancer treatment in postmenopausal women. The clinical impact of these findings for risk of vascular thrombosis warrants further studies.

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Changes in physical activity behavior and C-reactive protein in breast cancer patients

Annals of Behavioral Medicine ◽

10.1093/abm/kax010 ◽

2018 ◽

Vol 52 (7) ◽

pp. 545-551 ◽

Cited By ~ 4

Author(s):

Catherine M Sabiston ◽

Carsten Wrosch ◽

Andrée L Castonguay ◽

Benjamin D Sylvester

Keyword(s):

Breast Cancer ◽

Physical Activity ◽

Cancer Patients ◽

Physical Activity Behavior ◽

Breast Cancer Patients ◽

C Reactive Protein ◽

Reactive Protein ◽

Activity Behavior

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Influence of physical activity on the immune system in breast cancer patients during chemotherapy

Journal of Cancer Research and Clinical Oncology ◽

10.1007/s00432-017-2573-5 ◽

2018 ◽

Vol 144 (3) ◽

pp. 579-586 ◽

Cited By ~ 9

Author(s):

Thorsten Schmidt ◽

Walter Jonat ◽

Daniela Wesch ◽

Hans-Heinrich Oberg ◽

Sabine Adam-Klages ◽

...

Keyword(s):

Breast Cancer ◽

Physical Activity ◽

Immune System ◽

Cancer Patients ◽

Breast Cancer Patients

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Impact of physical activity on recurrence dynamics in early breast cancer patients

10.21203/rs.2.24350/v1 ◽

2020 ◽

Author(s):

Elia Mario Biganzoli ◽

Christine Desmedt ◽

Romano Demicheli

Keyword(s):

Breast Cancer ◽

Physical Activity ◽

Cancer Patients ◽

Rural Women ◽

Randomized Clinical Trials ◽

Urban Women ◽

Additive Models ◽

Breast Cancer Patients

Abstract Background Several studies have suggested that pre and/or postdiagnosis physical activity can reduce the risk of recurrence in breast cancer patients, however its effect according to follow-up time has not yet been investigated. Methods We analyzed recurrence and mortality dynamics in randomized clinical trials (RCTs) from Australia and Canada. The combined Australian RCTs evaluated, at median follow-up of 8.3 years, an 8-month pragmatic exercise intervention in 337 women with newly diagnosed breast cancer, while the Canadian RCT evaluated, at median follow-up of 7.4 years, supervised aerobic or resistance exercise during chemotherapy in 242 patients. For each RCT, the control arm consisted of patients undergoing usual care. We estimated the event dynamics by the discrete hazard function, through flexible regression of yearly conditional event probabilities with generalized additive models. Results In the considered RCTs, the recurrence and mortality risk of patients enrolled in the physical activity arm was stably reduced at medium/long term after five year of follow-up. In the Australian RCTs where patients were recruited by urban versus rural area, the latter group did not display benefit from physical activity. Estimated Odds Ratios (95% Confidence Intervals) for Disease Free Survival (DFS) in urban women were 0.63 (0.22-1.85); 0.27 (0.079-0.90); 0.11 (0.013-0.96) at the 3rd, 5th and 7th year of follow-up, respectively. For rural women, DFS patterns were overlapping with ORs approximating 1 at the different years of follow-up. Although not reaching statistical evidence, the estimates in the Canadian trial were in line with the results from the Australian urban women with ORs (95% CI) forDFS of 0.70 (0.33-1.50); 0.47 (0.19-1.18); 0.32 (0.077-1.29) at 3rd, 5th, 7th follow-up year, respectively. Conclusions While we acknowledge that the analyzed RCTs were not designed for investigating disease recurrence over time, these results support the evidence that physical activity reduces the risk of developing medium/long-term metastases. Additional translational research is needed to clarify the mechanisms underlying these observations.

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Temporal relationships between sleep and physical activity among breast cancer patients with insomnia.

Health Psychology ◽

10.1037/hea0000408 ◽

2016 ◽

Vol 35 (12) ◽

pp. 1307-1315 ◽

Cited By ~ 4

Author(s):

Paquito Bernard ◽

Hans Ivers ◽

Marie-Hélène Savard ◽

Josée Savard

Keyword(s):

Breast Cancer ◽

Physical Activity ◽

Cancer Patients ◽

Breast Cancer Patients ◽

Temporal Relationships

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Reduced rates of metabolism and decreased physical activity in breast cancer patients receiving adjuvant chemotherapy

American Journal of Clinical Nutrition ◽

10.1093/ajcn/65.5.1495 ◽

1997 ◽

Vol 65 (5) ◽

pp. 1495-1501 ◽

Cited By ~ 134

Author(s):

W Demark-Wahnefried ◽

V Hars ◽

M R Conaway ◽

K Havlin ◽

B K Rimer ◽

...

Keyword(s):

Breast Cancer ◽

Physical Activity ◽

Adjuvant Chemotherapy ◽

Cancer Patients ◽

Breast Cancer Patients

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Use of mHealth to increase physical activity among breast cancer survivors with fatigue, a qualitative exploration (Preprint)

10.2196/preprints.23927 ◽

2020 ◽

Author(s):

Elise Martin ◽

Antonio Di Meglio ◽

Cecile Charles ◽

Arlindo Ferreira ◽

Arnauld Gbenou ◽

...

Keyword(s):

Breast Cancer ◽

Physical Activity ◽

Cancer Patients ◽

Breast Cancer Survivors ◽

Organizational Factors ◽

Well Being ◽

Cancer Center ◽

Physical Factors ◽

Breast Cancer Patients ◽

Barriers To Physical Activity

BACKGROUND Physical activity has shown beneficial effects in the treatment of breast cancer fatigue, nevertheless a significant portion of patients remain insufficiently physically active after BC. Currently most patients has a smartphone and therefore mobile health (mHealth) holds the promise of promoting health behaviors uptake for many of them. OBJECTIVE In this study, we explored representations, levers and barriers to physical activity and mHealth interventions among inactive breast cancer patients with fatigue. METHODS This was an exploratory, qualitative study including breast cancer patients from a French Cancer Center. Four focus groups with a total of nine patients were conducted; two independent groups of patients were interviewed in two consecutive times, before and after their participation in a 2-week mHealth group experience. We used a thematic content analysis. RESULTS Several physical activity levers emerged including: 1) physical factors such as perception of physical benefit and previous practice, 2) psychological factors such as motivation increased by provider recommendations, 3) social factors such as group practice and 4) organizational factors including pre-planning physical activity sessions. The main barriers to physical activity identified included: 1) late effects of cancer treatment, 2) lack of motivation and 3) lack of time. The lack of familiarity with connected devices was perceived as the main barrier to the use of mHealth as a mean to promote physical activity. The tested mHealth group challenge was associated with several positive representations including: 1) well-being and good habits promotion, 2) motivational catalyzer. Following feedback, there where modifications implemented into the mHealth challenge. CONCLUSIONS mHealth-based, easily accessed group challenges were perceived as levers for the practice of physical activity in this population. mHealth-based group challenges should be explored as option to promote physical activity in a population with fatigue after breast cancer. CLINICALTRIAL NA

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Diet quality and its relationship with overweight and laboratory parameters in breast cancer patients undergoing treatment

10.21203/rs.2.11380/v2 ◽

2019 ◽

Author(s):

Krystal Ng LS ◽

Chan Yoke Mun ◽

Zalilah MS

Keyword(s):

Breast Cancer ◽

Physical Activity ◽

Fatty Acids ◽

Serum Albumin ◽

Cancer Patients ◽

Diet Quality ◽

Short Form ◽

Healthy Eating Index ◽

Breast Cancer Patients ◽

Laboratory Parameters

Abstract Background Overweight is the common issue existed among breast cancer patients, leading to poor cancer prognosis and survival. However, previous studies have focused merely on single nutrients or food groups. This study aimed to determine whether diet quality was associated with overweight and laboratory parameters among breast cancer patients undergoing treatment.Methods A cross sectional study comprises of 163 patients was conducted from January to May 2017. Diet quality and level of physical activity of patients were ascertained using Healthy Eating Index (HEI)-2015 and International Physical Activity Questionnaire (IPAQ)-short form, respectively. Data were available on body mass index and biochemical data, including of serum albumin, serum hemoblogbin and neutrophils count. Logistic regression was performed to identify the association between diet quality and overweight, serum albumin, serum hemoglobin and neutrophils count.Results The mean total HEI score (standard deviation) of the breast cancer patients was 63.86 (8.75). More than 80% of the subjects did not adhere to the dietary guidelines for whole grains, dairy, refined grains, ratio of poly- and mono-unsaturated fatty acids to saturated fatty acids components. In the multivariate model, those who perceived higher score of total HEI-2015 were less likely to experience overweight (Q4 vs Q1: OR=0.36; 95% CI=0.13, 0.99) while reported higher concentration of serum hemoglobin (Q4 vs Q1: OR=0.36; 95% CI=0.13, 0.98; Q3 vs Q1: OR=0.35; 95% CI=0.13, 0.92). Non-significant associations of diet quality were shown for serum albumin and neutrophils count.Conclusions A majority of breast cancer patients require dietary modification, especially for fatty acids, grains and dairy products. Diet quality may associate with overweight. A balanced diet that address the problem of overweight may help to maintain a good nutritional status and to improve cancer care in breast cancer patients during treatment. Future prospective studies are required to confirm this association.

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