Intralesional SD-101 in combination with pembrolizumab in anti-PD-1 treatment naive head and neck squamous cell carcinoma: results from a multicenter, phase 2 trial

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-21-1411 ◽

2021 ◽

pp. clincanres.1411.2021

Author(s):

Ezra E.W. Cohen ◽

Lisle Nabell ◽

Deborah J. Wong ◽

Terry Day ◽

Gregory A. Daniels ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Neck Squamous Cell Carcinoma ◽

Phase 2 ◽

Phase 2 Trial ◽

Multicenter Phase ◽

Treatment Naïve

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Palbociclib and cetuximab compared with placebo and cetuximab in platinum-resistant, cetuximab-naïve, human papillomavirus-unrelated recurrent or metastatic head and neck squamous cell carcinoma: A double-blind, randomized, phase 2 trial

Oral Oncology ◽

10.1016/j.oraloncology.2021.105192 ◽

2021 ◽

Vol 115 ◽

pp. 105192

Author(s):

Douglas R. Adkins ◽

Jin-Ching Lin ◽

Assuntina Sacco ◽

Jessica Ley ◽

Peter Oppelt ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Human Papillomavirus ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Neck Squamous Cell Carcinoma ◽

Phase 2 ◽

Double Blind ◽

Phase 2 Trial ◽

Randomized Phase 2

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Pembrolizumab plus cetuximab in patients with recurrent or metastatic head and neck squamous cell carcinoma: an open-label, multi-arm, non-randomised, multicentre, phase 2 trial

The Lancet Oncology ◽

10.1016/s1470-2045(21)00136-4 ◽

2021 ◽

Author(s):

Assuntina G Sacco ◽

Ruifeng Chen ◽

Francis P Worden ◽

Deborah J L Wong ◽

Douglas Adkins ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Neck Squamous Cell Carcinoma ◽

Phase 2 ◽

Multicentre Phase ◽

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Phase 2 Trial of AT-101 in Combination With Docetaxel for Recurrent, Locally Advanced, or Metastatic Head-and-Neck Squamous Cell Carcinoma (HNSCC)

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2013.11.140 ◽

2014 ◽

Vol 88 (2) ◽

pp. 507 ◽

Author(s):

A. Sacco ◽

J. Nor ◽

E. Belile ◽

A. Sukari ◽

D. Chepeha ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Locally Advanced ◽

Neck Squamous Cell Carcinoma ◽

Phase 2 ◽

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nab-Paclitaxel and cisplatin followed by cisplatin and radiation (Arm 1) and nab-paclitaxel followed by cetuximab and radiation (Arm 2) for locally advanced head and neck squamous-cell carcinoma: a multicenter, non-randomized phase 2 trial

Medical Oncology ◽

10.1007/s12032-021-01479-w ◽

2021 ◽

Vol 38 (4) ◽

Author(s):

Peter Oppelt ◽

Jessica Ley ◽

Mackenzie Daly ◽

Jason Rich ◽

Randal Paniello ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Locally Advanced ◽

Neck Squamous Cell Carcinoma ◽

Advanced Head ◽

Phase 2 ◽

Phase 2 Trial ◽

Randomized Phase 2

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Multicenter Phase 2 Trial of C is/Carboplatin, nAb -Paclitaxel, and C e TUX imab ( CACTUX ) as First-Line Therapy for Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2017.12.029 ◽

2018 ◽

Vol 100 (5) ◽

pp. 1311-1312 ◽

Author(s):

D. Adkins ◽

J. Ley ◽

O. Atiq ◽

C. Rigden ◽

K. Trinkaus ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Phase 2 ◽

First Line Therapy ◽

Phase 2 Trial ◽

Multicenter Phase ◽

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Palbociclib and cetuximab in cetuximab-resistant human papillomavirus-related oropharynx squamous-cell carcinoma: A multicenter phase 2 trial

Oral Oncology ◽

10.1016/j.oraloncology.2020.105164 ◽

2021 ◽

Vol 114 ◽

pp. 105164

Author(s):

Peter Oppelt ◽

Jessica C. Ley ◽

Francis Worden ◽

Kevin Palka ◽

Ronald Maggiore ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Human Papillomavirus ◽

Cell Carcinoma ◽

Squamous Cell ◽

Phase 2 ◽

Phase 2 Trial ◽

Multicenter Phase ◽

Oropharynx Squamous Cell Carcinoma

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Pembrolizumab for locally advanced and recurrent/metastatic cutaneous squamous cell carcinoma (KEYNOTE-629 Study): an open-label, nonrandomized, multicenter, phase 2 trial

Annals of Oncology ◽

10.1016/j.annonc.2021.07.008 ◽

2021 ◽

Author(s):

B.G.M. Hughes ◽

E. Munoz-Couselo ◽

L. Mortier ◽

Å. Bratland ◽

R. Gutzmer ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Locally Advanced ◽

Cutaneous Squamous Cell Carcinoma ◽

Phase 2 ◽

Phase 2 Trial ◽

Multicenter Phase

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Abstract 5530: PD-L1 expression in patients screened for phase 2 head and neck squamous cell carcinoma clinical studies (HAWK and CONDOR)

10.1158/1538-7445.am2018-5530 ◽

2018 ◽

Author(s):

Sophie Wildsmith ◽

Marietta Scott ◽

Anita Midha ◽

Craig Barker ◽

Jessica Whiteley ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Clinical Studies ◽

Neck Squamous Cell Carcinoma ◽

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Phase Ib/II, open label, multicenter study of intratumoral SD-101 in combination with pembrolizumab in anti-PD-1 treatment naïve patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC)

Annals of Oncology ◽

10.1093/annonc/mdy287.006 ◽

2018 ◽

Vol 29 ◽

pp. viii375 ◽

Author(s):

E.E.W. Cohen ◽

A. Algazi ◽

D. Laux ◽

D.J. Wong ◽

A. Amin ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Multicenter Study ◽

Neck Squamous Cell Carcinoma ◽

Phase Ib ◽

Treatment Naïve

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Updated Results of a Phase 2 Study of Biweekly Dose-Intense Paclitaxel Plus Gemcitabine (GEM/TAX) in Patients With Recurrent Locoregional or Metastatic Head-and-Neck Squamous Cell Carcinoma

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2013.11.137 ◽

2014 ◽

Vol 88 (2) ◽

pp. 506

Author(s):

M. Salem ◽

M. Kaufman ◽

S. Shahrestani ◽

M. Al-Hajeili ◽

J. Jacobs ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Neck Squamous Cell Carcinoma ◽

Phase 2 ◽

Download Full-text