Abstract 2866: Exploring the basis for platinum and ionizing radiation combination with R1507 (an anti-IGF1R monoclonal antibody) in a small cell lung cancer (SCLC) model using integrated functional and genomic approaches on both short- and long-term drug exposure reveals adaptive mechanisms

Author(s):  
Charles Ferte ◽  
Frederic Commo ◽  
Yohann Loriot ◽  
Celine Clemenson ◽  
Saad Hamama ◽  
...  
Lung Cancer ◽  
2008 ◽  
Vol 61 (2) ◽  
pp. 202-208 ◽  
Author(s):  
Federico Rea ◽  
Giuseppe Marulli ◽  
Marco Schiavon ◽  
Andrea Zuin ◽  
Abdel-Mohsen Hamad ◽  
...  

2021 ◽  
Vol 9 (4) ◽  
pp. 325-325
Author(s):  
Yusuke Takahashi ◽  
Shigeki Suzuki ◽  
Kenichi Hamada ◽  
Takeo Nakada ◽  
Yuko Oya ◽  
...  

2020 ◽  
Author(s):  
Yang Yang ◽  
Kai Wang ◽  
Qingquan Ren ◽  
Ruibin Xu ◽  
Jianfeng Guo

Abstract Objective This study aimed to explore the short-and long-term outcomes of video-assisted thoracoscopic (VATS) lobectomy in older patients with non-small-cell lung cancer (NSCLC). Methods A total of 218 NSCLC patient data between January 2014 and January 2019, which included pathological, clinical, and follow-up surveys on VATS lobectomy, were retrospectively analyzed. Of the 218-patient data analyzed, a total of 77 patients were 70 years of age and older (elderly group), while a total of 141 patients were below 70 years of age (nonelderly group).Results Concerning general preoperative data, the simplified comorbidity score (SCS) and the American Society of Anesthesiologists (ASA) scores were higher in the elderly patient group as compared to the nonelderly patient group. Also, elderly patients had poor pulmonary function performance as compared to their counterparts. There were, however, no significant statistical differences found with surgical data between the two groups concerning intraoperative blood loss, operation duration, and conversion to thoracotomy. None of the patients in either of the groups died within thirty days of the operation. Additionally, there were no significant statistical differences in the five-year overall survival rate and the five-year disease-free survival rate between both groups.Conclusion NSCLC treatment with VATS lobectomy is safe and feasible in elderly patients, and it can provide excellent long-term outcomes. However, it is necessary to strengthen perioperative management and promote early postoperative recovery to reduce complications.


2019 ◽  
Vol 20 (23) ◽  
pp. 6026
Author(s):  
Hwani Ryu ◽  
Hyo Jeong Kim ◽  
Jie-Young Song ◽  
Sang-Gu Hwang ◽  
Jae-Sung Kim ◽  
...  

We previously reported on a poly (ADP-ribose) polymerase (PARP) 1/2 inhibitor N-(3-(hydroxycarbamoyl)phenyl)carboxamide (designated KJ-28d), which increased the death of human ovarian cancer BRCA1-deficient SNU-251 cells. In the present study, we further investigated the antitumor activities of KJ-28d in BRCA-proficient non-small cell lung cancer (NSCLC) cells to expand the use of PARP inhibitors. KJ-28d significantly inhibited the growth of NSCLC cells in vitro and in vivo, and induced DNA damage and reactive oxygen species in A549 and H1299 cells. Combined treatment with KJ-28d and ionizing radiation led to increased DNA damage responses in A549 and H1299 cells compared to KJ-28d or ionizing radiation alone, resulting in apoptotic cell death. Moreover, the combination of KJ-28d plus a DNA-damaging therapeutic agent (carboplatin, cisplatin, paclitaxel, or doxorubicin) synergistically inhibited cell proliferation, compared to either drug alone. Taken together, the findings demonstrate the potential of KJ-28d as an effective anti-cancer therapeutic agent for BRCA-deficient and -proficient cancer cells. KJ-28d might have potential as an adjuvant when used in combination with radiotherapy or DNA-damaging agents, pending further investigations.


Sign in / Sign up

Export Citation Format

Share Document