Abstract 217: BCR-ABL tyrosine kinase inhibition combined with a novel pan BCL2 family inhibitor abrogates leukemia stem cell survival in a niche-dependent manner.

2013 ◽  
Author(s):  
Wenxue Ma ◽  
Janine Low-Marchelli ◽  
Heather S. Leu ◽  
Angela Court Recart ◽  
Jun Wei ◽  
...  
Keyword(s):  
Stem Cell ◽  
Tyrosine Kinase ◽  
Cell Survival ◽  
Dependent Manner ◽  
Leukemia Stem Cell ◽  
Kinase Inhibition ◽  
Tyrosine Kinase Inhibition ◽  
Bcl2 Family ◽  
Abl Tyrosine Kinase ◽  
Stem Cell Survival

Novel α-Aminophosphonates of imatinib Intermediate: Synthesis, anticancer Activity, human Abl tyrosine kinase Inhibition, ADME and toxicity prediction

2021 ◽  
Vol 109 ◽  
pp. 104718
Author(s):  
Saikiran Aita ◽  
Vishnu Nayak Badavath ◽  
Mohan Gundluru ◽  
Murali Sudileti ◽  
Bakthavatchala Reddy Nemallapudi ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Anticancer Activity ◽  
Toxicity Prediction ◽  
Kinase Inhibition ◽  
Tyrosine Kinase Inhibition ◽  
Abl Tyrosine Kinase

scholarly journals Abstract 1114: IGFBP7 reduces acute myeloid leukemia stem cell survival without affecting normal hematopoiesis

2018 ◽  
Author(s):  
Han J. Verhagen ◽  
Noortje van Gils ◽  
Anna van Rhenen ◽  
Arjo Rutten ◽  
Marjon Smit ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Stem Cell ◽  
Cell Survival ◽  
Myeloid Leukemia ◽  
Leukemia Stem Cell ◽  
Stem Cell Survival ◽  
Acute Myeloid

scholarly journals Arachidonate 15-lipoxygenase is required for chronic myeloid leukemia stem cell survival

2014 ◽  
Vol 124 (9) ◽  
pp. 3847-3862 ◽  
Author(s):  
Yaoyu Chen ◽  
Cong Peng ◽  
Sheela A. Abraham ◽  
Yi Shan ◽  
Zhiru Guo ◽  
...  
Keyword(s):  
Stem Cell ◽  
Chronic Myeloid Leukemia ◽  
Cell Survival ◽  
Myeloid Leukemia ◽  
Leukemia Stem Cell ◽  
Stem Cell Survival

The Response of Testes Cells to Low Level, Single dose Helium Particle Irradiation

1982 ◽  
Vol 40 ◽  
pp. 252-253
Author(s):  
D.E. Philpott ◽  
W. Sapp ◽  
C. Williams ◽  
J. Stevenson ◽  
S. Black ◽  
...  
Keyword(s):  
Stem Cell ◽  
Single Dose ◽  
B Cell ◽  
Cell Survival ◽  
Spermatogonial Stem Cell ◽  
Low Doses ◽  
Particle Irradiation ◽  
Stem Cell Survival ◽  
Irradiation Injury ◽  
Radio Sensitivity

Spermatogonial stem-cell survival after irradiation injury has been studied in rodents by histological counts of surviving cells. Many studies, including previous work from our laboratory, show that the spermatogonial population demonstrates a heterogeneous response to irradiation. The spermatogonia increase in radio-sensitivity as differentiation proceeds through the sequence As - Apr - A1 - A2 - A3 - A4 - In - B. The stem (As) cell is the most resistant and the B cell is the most sensitive. The purpose of this work is to investigate the response of spermatogonial cell to low doses (less than 10 0 rads) of helium particle irradiation.

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