Abstract 2529: A prospective cohort study of body size and risk of head and neck cancers in the NIH-AARP Diet and Health Study.

ObjectiveThe objective of this study was to examine the longitudinal associations of exercise frequency with the incidence of myocardial infarction, stroke, hypertension, type 2 diabetes and 10 different cancer outcomes.DesignA prospective cohort study.SettingPhysical examination data linked with the entire South Korean population’s health insurance system: from 2002 to 2015.Participants257 854 South Korean adults who provided up to 7 repeat measures of exercise (defined as exercises causing sweat) and confounders.Primary outcome measuresEach disease incidence was defined using both fatal and non-fatal health records (a median follow-up period of 13 years).ResultsCompared with no exercise category, the middle categories of exercise frequency (3–4 or 5–6 times/week) showed the lowest risk of myocardial infarction (HR 0.79; 95% CI 0.70 to 0.90), stroke (HR 0.80; 95% CI 0.73 to 0.89), hypertension (HR 0.86; 95% CI 0.85 to 0.88), type 2 diabetes (HR 0.87; 95% CI 0.84 to 0.89), stomach (HR 0.87; 95% CI 0.79 to 0.96), lung (HR 0.80; 95% CI 0.71 to 0.91), liver (HR 0.85; 95% CI 0.75 to 0.98) and head and neck cancers (HR 0.76; 95% CI 0.63 to 0.93; for 1–2 times/week), exhibiting J-shaped associations. There was, in general, little evidence of effect modification by body mass index, smoking, alcohol consumption, family history of disease and sex in these associations.ConclusionsModerate levels of sweat-inducing exercise showed the lowest risk of myocardial infarction, stroke, hypertension, type 2 diabetes, stomach, lung, liver and head and neck cancers. Public health and lifestyle interventions should, therefore, promote moderate levels of sweat-causing exercise as a behavioural prevention strategy for non-communicable diseases in a wider population of East Asians.

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Explaining the effects of socio-economic deprivation on survival in a national prospective cohort study of 1909 patients with head and neck cancers

Cancer Epidemiology ◽

10.1016/j.canep.2010.05.009 ◽

2010 ◽

Vol 34 (6) ◽

pp. 682-688 ◽

Cited By ~ 16

Author(s):

Gerry Robertson ◽

Nicola Greenlaw ◽

Caroline A. Bray ◽

David S. Morrison

Keyword(s):

Cohort Study ◽

Head And Neck ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Head And Neck Cancers ◽

Economic Deprivation

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Health anxiety and risk of ischaemic heart disease: a prospective cohort study linking the Hordaland Health Study (HUSK) with the Cardiovascular Diseases in Norway (CVDNOR) project

BMJ Open ◽

10.1136/bmjopen-2016-012914 ◽

2016 ◽

Vol 6 (11) ◽

pp. e012914 ◽

Cited By ~ 14

Author(s):

Line Iden Berge ◽

Jens Christoffer Skogen ◽

Gerhard Sulo ◽

Jannicke Igland ◽

Ingvard Wilhelmsen ◽

...

Keyword(s):

Cohort Study ◽

Heart Disease ◽

Cardiovascular Diseases ◽

Ischaemic Heart Disease ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Health Anxiety ◽

Health Study

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PO-1011 Efficacy of PD-1 inhibition in recurrent Head and Neck cancer. A national prospective cohort study.

Radiotherapy and Oncology ◽

10.1016/s0167-8140(21)07462-4 ◽

2021 ◽

Vol 161 ◽

pp. S840

Author(s):

S. Søby ◽

A. Gothelf ◽

N. Gyldenkerne ◽

J. Bentzen ◽

K. Nowicka-Matus ◽

...

Keyword(s):

Cohort Study ◽

Head And Neck Cancer ◽

Head And Neck ◽

Prospective Cohort Study ◽

Neck Cancer ◽

Prospective Cohort ◽

Recurrent Head

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Pattern of Nutritional status in Node Negative versus Node Positive Head and Neck Cancer patients undergoing treatment - a prospective cohort study

10.21203/rs.3.rs-1071915/v1 ◽

2022 ◽

Author(s):

Anshika Arora ◽

Sunil Saini ◽

Meenu Gupta

Keyword(s):

Cohort Study ◽

Nutritional Status ◽

Head And Neck ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Cell Cancer ◽

Node Negative ◽

Node Positive ◽

Pre Treatment ◽

Single Modality

Abstract Purpose The aim of this study was to study the nutritional profile of node negative and node positive patients undergoing treatment for head and neck squamous cell cancer (HNSCC). Methods This prospective cohort study was conducted between 2018 and 2020. Patients diagnosed with HNSCC, planned for treatment were enrolled after written informed consent. In Node negative(N0) and Node positive(N+) cohorts of patients, nutritional status was determined using- anthropometric measures and Subjective Global Assessment (SGA) scale pre-treatment, during and after treatment. Statistical analysis was performed using SPSS version 22. Data was analyzed using parametric and non-parametric tests, p value of 0.05 was considered significant. Results 161 patients were analyses, 73 N0 and 88 N+ cohorts. Pre-treatment, 9.6 to 20.4% patients in N0 and 23.9 to 32.8% patients in N+ cohorts were malnourished. Incidence of malnutrition at completion of treatment was 40.8–52.5% overall, 20.5–41.1% N0, 39.5–62.8% N+. Mean reduction in weight (11.1% ±7.82 v/s 6.26% ±8.3, p=0.000), mean reduction in BMI (2.57 ±1.87 v/s 1.29 ±1.62, p=0.000), median reduction in MUAC (2cm v/s 1cm, p=0.000) and median increase in SGA score were higher (13 v/s 6, p=0.000) in multi-modality as compared to single modality treatment. Similar findings were noted in N0 and N+ cohorts. Conclusion As compared to N0, N+ patients had higher burden of malnutrition at diagnosis, more worsening of nutritional parameters during treatment. More decline in Nutritional status was seen in patients receiving multi-modality as compared to single modality treatment.

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Menstrual cycle regularity and length across the reproductive lifespan and risk of premature mortality: prospective cohort study

BMJ ◽

10.1136/bmj.m3464 ◽

2020 ◽

pp. m3464 ◽

Cited By ~ 3

Author(s):

Yi-Xin Wang ◽

Mariel Arvizu ◽

Janet W Rich-Edwards ◽

Jennifer J Stuart ◽

JoAnn E Manson ◽

...

Keyword(s):

Cardiovascular Disease ◽

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Cycle Length ◽

Premature Mortality ◽

Health Study ◽

Menstrual Cycles ◽

Hazard Ratios

AbstractObjectiveTo evaluate whether irregular or long menstrual cycles throughout the life course are associated with all cause and cause specific premature mortality (age <70 years).DesignProspective cohort study.SettingNurses’ Health Study II (1993-2017).Participants79 505 premenopausal women without a history of cardiovascular disease, cancer, or diabetes and who reported the usual length and regularity of their menstrual cycles at ages 14-17 years, 18-22 years, and 29-46 years.Main outcome measuresHazard ratios and 95% confidence intervals for all cause and cause specific premature mortality (death before age 70 years) were estimated from multivariable Cox proportional hazards models.ResultsDuring 24 years of follow-up, 1975 premature deaths were documented, including 894 from cancer and 172 from cardiovascular disease. Women who reported always having irregular menstrual cycles experienced higher mortality rates during follow-up than women who reported very regular cycles in the same age ranges. The crude mortality rate per 1000 person years of follow-up for women reporting very regular cycles and women reporting always irregular cycles were 1.05 and 1.23 for cycle characteristics at ages 14-17 years, 1.00 and 1.37 for cycle characteristics at ages 18-22 years, and 1.00 and 1.68 for cycle characteristics at ages 29-46 years. The corresponding multivariable adjusted hazard ratios for premature death during follow-up were 1.18 (95% confidence interval 1.02 to 1.37), 1.37 (1.09 to 1.73), and 1.39 (1.14 to 1.70), respectively. Similarly, women who reported that their usual cycle length was 40 days or more at ages 18-22 years and 29-46 years were more likely to die prematurely than women who reported a usual cycle length of 26-31 days in the same age ranges (1.34, 1.06 to 1.69; and 1.40, 1.17 to 1.68, respectively). These relations were strongest for deaths related to cardiovascular disease. The higher mortality associated with long and irregular menstrual cycles was slightly stronger among current smokers.ConclusionsIrregular and long menstrual cycles in adolescence and adulthood are associated with a greater risk of premature mortality (age <70 years). This relation is slightly stronger among women who smoke.

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Correction to: Advancing interdisciplinary research in head and neck cancer through a multicenter longitudinal prospective cohort study: the NETherlands QUality of life and BIomedical Cohort (NET-QUBIC) data warehouse and biobank

BMC Cancer ◽

10.1186/s12885-019-6223-y ◽

2019 ◽

Vol 19 (1) ◽

Author(s):

I. M. Verdonck-de Leeuw ◽

F. Jansen ◽

R. H. Brakenhoff ◽

J. A. Langendijk ◽

R. Takes ◽

...

Keyword(s):

Quality Of Life ◽

Cohort Study ◽

Head And Neck Cancer ◽

The Netherlands ◽

Head And Neck ◽

Data Warehouse ◽

Prospective Cohort Study ◽

Interdisciplinary Research ◽

Prospective Cohort

Following publication of the original article [1], the authors reported the name of R.J. Baatenburg de Jong was incorrectly tagged in the HTML version of the article.

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