Abstract 1142: Novel target discovery for glioblastoma using chemical biology fingerprinting

2017 ◽  
Author(s):  
Darren Finlay ◽  
Pedro Aza-Blanc ◽  
Harshil Dhruv ◽  
Alexey Eroshkin ◽  
Craig Hauser ◽  
...  
Keyword(s):  
Chemical Biology ◽  
Target Discovery ◽  
Novel Target

scholarly journals BrainSeq: Neurogenomics to Drive Novel Target Discovery for Neuropsychiatric Disorders

Neuron ◽  
2015 ◽  
Vol 88 (6) ◽  
pp. 1078-1083 ◽  
Author(s):  
Christian R. Schubert ◽  
Patricio O’Donnell ◽  
Jie Quan ◽  
Jens R. Wendland ◽  
Hualin S. Xi ◽  
...  
Keyword(s):  
Neuropsychiatric Disorders ◽  
Target Discovery ◽  
Novel Target

Antisense Antibiotics: A Brief Review of Novel Target Discovery and Delivery

2010 ◽  
Vol 7 (2) ◽  
pp. 76-85 ◽  
Author(s):  
Hui Bai ◽  
Xiaoyan Xue ◽  
Zheng Hou ◽  
Ying Zhou ◽  
Jingru Meng ◽  
...  
Keyword(s):  
Target Discovery ◽  
Novel Target

scholarly journals UCHL1 as a novel target in breast cancer: emerging insights from cell and chemical biology

2021 ◽  
Author(s):  
Milon Mondal ◽  
Daniel Conole ◽  
Jaya Nautiyal ◽  
Edward W. Tate
Keyword(s):  
Breast Cancer ◽  
Drug Target ◽  
Chemical Biology ◽  
Treatment Options ◽  
Survival Rates ◽  
Cancer Types ◽  
Carboxyl Terminal ◽  
Novel Target ◽  
Substrate Proteins ◽  
Estrogen Receptor Negative

AbstractBreast cancer has the highest incidence and death rate among cancers in women worldwide. In particular, metastatic estrogen receptor negative (ER–) breast cancer and triple-negative breast cancer (TNBC) subtypes have very limited treatment options, with low survival rates. Ubiquitin carboxyl terminal hydrolase L1 (UCHL1), a ubiquitin C-terminal hydrolase belonging to the deubiquitinase (DUB) family of enzymes, is highly expressed in these cancer types, and several key reports have revealed emerging and important roles for UCHL1 in breast cancer. However, selective and potent small-molecule UCHL1 inhibitors have been disclosed only very recently, alongside chemical biology approaches to detect regulated UHCL1 activity in cancer cells. These tools will enable novel insights into oncogenic mechanisms driven by UCHL1, and identification of substrate proteins deubiquitinated by UCHL1, with the ultimate goal of realising the potential of UCHL1 as a drug target in breast cancer.

FEATURES

2011 ◽  
Vol 15 (12) ◽  
pp. 15-31 ◽  
Keyword(s):  
Drug Discovery ◽  
South Korea ◽  
Research Center ◽  
Target Discovery ◽  
Current State ◽  
Novel Target

Biorefinery Research in Korea. Genomics and Bioinformatics in Korea. Current State of Biomass Technology (BmT) Research in South Korea: Advanced Biomass R&D Center (ABC). Medicinal Bioconvergence Research Center: Innovation of Drug Discovery through Novel Target Discovery and Convergence Technology.

MHC-bound antigens and proteomics for novel target discovery

2004 ◽  
Vol 5 (7) ◽  
pp. 845-859 ◽  
Author(s):  
Stacy H Shoshan ◽  
Arie Admon
Keyword(s):  
Target Discovery ◽  
Novel Target
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