Abstract 1745: Inhibition of chemokine receptor 2 (CCR2) with a small molecule antagonist enhances the effectiveness of checkpoint inhibition by altering the tumor microenvironment in mouse colorectal tumors: Reducing tumor size and increasing long term survival

AbstractHepatocellular carcinoma (HCC) is usually associated with varying degrees of cirrhosis. Among cirrhotic patients with solitary HCC in the absence of macro-vascular invasion, whether tumor size drives prognosis or not after hepatectomy remains unknown. This study aimed to investigate the prognostic impact of tumor size on long-term outcomes after hepatectomy for solitary HCC patients with cirrhosis and without macrovascular invasion. A total of 813 cirrhotic patients who underwent curative hepatectomy for solitary HCC and without macrovascular invasion between 2001 and 2014 were retrospectively studied. We set 5 cm as the tumor cut-off value. Propensity score matching (PSM) was performed to minimize the influence of potential confounders including cirrhotic severity that was histologically assessed according to the Laennec staging system. Recurrence-free survival (RFS) and overall survival (OS) were compared between the two groups before and after PSM. Overall, 464 patients had tumor size ≤ 5 cm, and 349 had tumor size > 5 cm. The 5-year RFS and OS rates were 38.3% and 61.5% in the ≤ 5 cm group, compared with 25.1% and 59.9% in the > 5 cm group. Long-term survival outcomes were significantly worse as tumor size increased. Multivariate analysis indicated that tumor size > 5 cm was an independent risk factor for tumor recurrence and long-term survival. These results were further confirmed in the PSM cohort of 235 pairs of patients. In cirrhotic patients with solitary HCC and without macrovascular invasion, tumor size may significantly affect the prognosis after curative hepatectomy.

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Impact of tumor size on the long-term survival of patients with early stage renal cell cancer

World Journal of Urology ◽

10.1007/s00345-004-0483-z ◽

2005 ◽

Vol 23 (1) ◽

pp. 50-54 ◽

Cited By ~ 10

Author(s):

M. Kuczyk ◽

G. Wegener ◽

A. S. Merseburger ◽

A. Anastasiadis ◽

S. Machtens ◽

...

Keyword(s):

Renal Cell Cancer ◽

Tumor Size ◽

Renal Cell ◽

Early Stage ◽

Cell Cancer ◽

Term Survival ◽

Long Term Survival

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Actual Long-Term Survival After Resection of Stage III Soft Tissue Sarcoma

10.21203/rs.3.rs-72207/v1 ◽

2020 ◽

Author(s):

Do Weon Lee ◽

Han-Soo Kim ◽

Ilkyu Han

Keyword(s):

Soft Tissue ◽

Soft Tissue Sarcoma ◽

Tumor Size ◽

Poor Prognosis ◽

Histological Grade ◽

Stage Iii ◽

Term Survival ◽

Long Term Survival ◽

Long Term Survivors

Abstract Background: Actuarial survival based on the Kaplan–Meier method can overestimate actual long-term survival, especially among those with factors of poor prognosis. Patients with American Joint Committee on Cancer stage III soft tissue sarcoma (STS) represent a subset with a high risk of STS-specific mortality. Therefore, we aimed to characterize the clinicopathological characteristics associated with actual long-term survival in patients with stage III STS.Methods: We retrospectively reviewed 116 patients who underwent surgical resection for stage III STS with curative intent between March 2000 and December 2013. Long-term survivors (n = 61), defined as those who survived beyond 5 years, were compared with short-term survivors (n = 36), who died of STS within 5 years.Results: Multivariate logistic regression analyses showed that a tumor size <10 cm [odds ratio (OR) 3.95, p = 0.047], histological grade of 2 (OR 8.12, p = 0.004), and American Society of Anesthesiologists (ASA) score of 1 (OR 11.25, p = 0.001) were independently associated with actual 5-year survival. However, 66% of the long-term survivors exhibited factors of poor prognosis: 36% had a tumor size >10 cm and 48% had a histological grade of 3. Leiomyosarcoma (3 of 10) was negatively associated with actual long-term survival.Conclusions: Actual 5-year survival after resection of stage III STS was associated with tumor size, histological grade, and ASA score. However, majority of the actual 5-year survivors exhibit factors of poor prognosis, suggesting that resection should be offered for a chance of long-term survival in these patients.

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Long-Term Survival in Patients With T2 Hepatocellular Carcinoma After Primary Curative Resection Can Be Further Stratified by Tumor Size

Medicine ◽

10.1097/md.0000000000000203 ◽

2014 ◽

Vol 93 (27) ◽

pp. e203 ◽

Cited By ~ 5

Author(s):

Cheng-Maw Ho ◽

Rey-Heng Hu ◽

Po-Huang Lee ◽

Yao-Ming Wu ◽

Ming-Chih Ho

Keyword(s):

Hepatocellular Carcinoma ◽

Tumor Size ◽

Curative Resection ◽

Term Survival ◽

Long Term Survival

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Actual long-term survival after resection of stage III soft tissue sarcoma

BMC Cancer ◽

10.1186/s12885-020-07730-3 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Do Weon Lee ◽

Han-Soo Kim ◽

Ilkyu Han

Keyword(s):

Soft Tissue ◽

Soft Tissue Sarcoma ◽

Tumor Size ◽

Poor Prognosis ◽

Histological Grade ◽

Stage Iii ◽

Term Survival ◽

Long Term Survival ◽

Long Term Survivors

Abstract Background Actuarial survival based on the Kaplan–Meier method can overestimate actual long-term survival, especially among those with factors of poor prognosis. Patients with American Joint Committee on Cancer stage III soft tissue sarcoma (STS) represent a subset with a high risk of STS-specific mortality. Therefore, we aimed to characterize the clinicopathological characteristics associated with actual long-term survival in patients with stage III STS. Methods We retrospectively reviewed 116 patients who underwent surgical resection for stage III STS with curative intent between March 2000 and December 2013. Long-term survivors (n = 61), defined as those who survived beyond 5 years, were compared with short-term survivors (n = 36), who died of STS within 5 years. Results Multivariate logistic regression analyses showed that a tumor size < 10 cm [odds ratio (OR) 3.95, p = 0.047], histological grade of 2 (OR 8.12, p = 0.004), and American Society of Anesthesiologists (ASA) score of 1 (OR 11.25, p = 0.001) were independently associated with actual 5-year survival. However, 66% of the long-term survivors exhibited factors of poor prognosis: 36% had a tumor size > 10 cm and 48% had a histological grade of 3. Leiomyosarcoma (3 of 10) was negatively associated with actual long-term survival. Conclusions Actual 5-year survival after resection of stage III STS was associated with tumor size, histological grade, and ASA score. However, majority of the actual 5-year survivors exhibit factors of poor prognosis, suggesting that aggressive treatment should be offered for a chance of long-term survival in these patients.

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Tumor size predicts long term survival in colon cancer: an analysis of the National Cancer Data Base

Journal of the American College of Surgeons ◽

10.1016/j.jamcollsurg.2014.07.589 ◽

2014 ◽

Vol 219 (4) ◽

pp. e77

Author(s):

Sukamal Saha ◽

Mohammed Shaik ◽

Lindsay Berbiglia ◽

Supriya K. Saha ◽

Gregory Johnston ◽

...

Keyword(s):

Colon Cancer ◽

Data Base ◽

Tumor Size ◽

National Cancer Data Base ◽

Term Survival ◽

Long Term Survival ◽

Cancer Data

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18F-FET PET Uptake Characteristics of Long-Term IDH-Wildtype Diffuse Glioma Survivors

Cancers ◽

10.3390/cancers13133163 ◽

2021 ◽

Vol 13 (13) ◽

pp. 3163

Author(s):

Lena M. Mittlmeier ◽

Bogdana Suchorska ◽

Viktoria Ruf ◽

Adrien Holzgreve ◽

Matthias Brendel ◽

...

Keyword(s):

Tumor Size ◽

Tumor Volume ◽

Molecular Genetic ◽

Who Grade ◽

Term Survival ◽

Long Term Survival ◽

Fet Pet ◽

Who Grade Iii ◽

Grade Iii

Background: IDHwt diffuse gliomas represent the tumor entity with one of the worst clinical outcomes. Only rare cases present with a long-term survival of several years. Here we aimed at comparing the uptake characteristics on dynamic 18F-FET PET, clinical and molecular genetic parameters of long-term survivors (LTS) versus short-term survivors (STS): Methods: Patients with de-novo IDHwt glioma (WHO grade III/IV) and 18F-FET PET prior to any therapy were stratified into LTS (≥36 months survival) and STS (≤15 months survival). Static and dynamic 18F-FET PET parameters (mean/maximal tumor-to-background ratio (TBRmean/max), biological tumor volume (BTV), minimal time-to-peak (TTPmin)), diameter and volume of contrast-enhancement on MRI, clinical parameters (age, sex, Karnofksy-performance-score), mode of surgery; initial treatment and molecular genetics were assessed and compared between LTS and STS. Results: Overall, 75 IDHwt glioma patients were included (26 LTS, 49 STS). LTS were significantly younger (p < 0.001), had a higher rate of WHO grade III glioma (p = 0.032), of O(6)-Methylguanine-DNA methyltransferase (MGMT) promoter methylation (p < 0.001) and missing Telomerase reverse transcriptase promoter (TERTp) mutations (p = 0.004) compared to STS. On imaging, LTS showed a smaller median BTV (p = 0.017) and a significantly longer TTPmin (p = 0.008) on 18F-FET PET than STS, while uptake intensity (TBRmean/max) did not differ. In contrast to the tumor-volume on PET, MRI-derived parameters such as tumor size as well as all other above-mentioned parameters did not differ between LTS and STS (p > 0.05 each). Conclusion: Besides molecular genetic prognosticators, a long survival time in IDHwt glioma patients is associated with a longer TTPmin as well as a smaller BTV on 18F-FET PET at initial diagnosis. 18F-FET uptake intensity as well as the MRI-derived tumor size (volume and maximal diameter) do not differ in patients with long-term survival.

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