Abstract 77: Therapeutic potential of ERK inhibitors in overcoming acquired resistance to third generation EGFR tyrosine kinase inhibitors

Kinase Inhibitors ◽

Therapeutic Potential ◽

Acquired Resistance ◽

Third Generation ◽

Egfr Tyrosine Kinase ◽

Abstract 77: Therapeutic potential of ERK inhibitors in overcoming acquired resistance to third generation EGFR tyrosine kinase inhibitors

10.1158/1538-7445.sabcs18-77 ◽

2019 ◽

Author(s):

Yiting Li ◽

Guoqing Qian ◽

Taofeek K. Owonikoko ◽

Suresh S. Ramalingam ◽

Shi-Yong Sun

Keyword(s):

Tyrosine Kinase ◽

Kinase Inhibitors ◽

Therapeutic Potential ◽

Acquired Resistance ◽

Third Generation ◽

Egfr Tyrosine Kinase ◽

Managing Acquired Resistance to Third-Generation EGFR Tyrosine Kinase Inhibitors Through Co-Targeting MEK/ERK Signaling

Lung Cancer Targets and Therapy ◽

10.2147/lctt.s293902 ◽

2021 ◽

Vol Volume 12 ◽

pp. 1-10

Author(s):

Danlei Yu ◽

Wen Zhao ◽

Karin A Vallega ◽

Shi-Yong Sun

Keyword(s):

Tyrosine Kinase ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Erk Signaling ◽

Third Generation ◽

Egfr Tyrosine Kinase ◽

P76.85 Afatinib and Necitumumab in EGFR mutant NSCLC with Acquired Resistance to 1st or 3rd Generation EGFR Tyrosine Kinase Inhibitors

Journal of Thoracic Oncology ◽

10.1016/j.jtho.2021.01.1142 ◽

2021 ◽

Vol 16 (3) ◽

pp. S626

Author(s):

S. Padda ◽

J. Whisenant ◽

J. Neal ◽

S. York ◽

W. Iams ◽

...

Keyword(s):

Tyrosine Kinase ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors ◽

Egfr Mutant

Mutational spectrum of acquired resistance to reversible versus irreversible EGFR tyrosine kinase inhibitors

BMC Cancer ◽

10.1186/s12885-020-06920-3 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Svenja Wagener-Ryczek ◽

Carina Heydt ◽

Juliane Süptitz ◽

Sebastian Michels ◽

Markus Falk ◽

...

Keyword(s):

Tyrosine Kinase ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Mutational Spectrum ◽

Egfr Tyrosine Kinase ◽

Abstract 742: Effect of Hsp90 inhibitor NVP-AUY922 with radiation on lung adenocarcinoma cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors

10.1158/1538-7445.am2015-742 ◽

2015 ◽

Author(s):

Yuho Maki ◽

Shinsuke Hashida ◽

Hiromasa Yamamoto ◽

Kazuhiko Shien ◽

Tomoaki Ohtsuka ◽

...

Keyword(s):

Tyrosine Kinase ◽

Lung Adenocarcinoma ◽

Cell Lines ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Hsp90 Inhibitor ◽

Adenocarcinoma Cell ◽

Egfr Tyrosine Kinase ◽

Efficacy of second and third generation EGFR tyrosine kinase inhibitors, alone or in combination, in T790M-mediated resistance

Annals of Oncology ◽

10.1093/annonc/mdw362.13 ◽

2016 ◽

Vol 27 ◽

pp. vi4

Author(s):

F. Papaccio ◽

C.M. Della Corte ◽

G. Viscardi ◽

G. Esposito ◽

M. Fasano ◽

...

Keyword(s):

Tyrosine Kinase ◽

Kinase Inhibitors ◽

Third Generation ◽

Egfr Tyrosine Kinase ◽

An activation of LC3A-mediated autophagy contributes tode novoand acquired resistance to EGFR tyrosine kinase inhibitors in lung adenocarcinoma

The Journal of Pathology ◽

10.1002/path.4354 ◽

2014 ◽

pp. n/a-n/a ◽

Cited By ~ 9

Author(s):

Kaito Nihira ◽

Yasuhiro Miki ◽

Shinya Iida ◽

Sodai Narumi ◽

Katsuhiko Ono ◽

...

Keyword(s):

Tyrosine Kinase ◽

Lung Adenocarcinoma ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Egfr Tyrosine Kinase ◽

Acquired Resistance to EGFR Tyrosine Kinase Inhibitors is Associated With Low Efficacy of Radiation Therapy for Brain Metastases From EGFR-mutant Lung Adenocarcinoma

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2012.07.166 ◽

2012 ◽

Vol 84 (3) ◽

pp. S102

Author(s):

H. Hirata ◽

K. Nakamura ◽

N. Kunitake ◽

Y. Shioyama ◽

T. Sasaki ◽

...

Keyword(s):

Radiation Therapy ◽

Brain Metastases ◽

Tyrosine Kinase ◽

Lung Adenocarcinoma ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors ◽

Egfr Mutant

Mechanisms of acquired resistance to first- and second-generation EGFR tyrosine kinase inhibitors

Annals of Oncology ◽

10.1093/annonc/mdx703 ◽

2018 ◽

Vol 29 ◽

pp. i10-i19 ◽

Cited By ~ 104

Author(s):

D. Westover ◽

J. Zugazagoitia ◽

B.C. Cho ◽

C.M. Lovly ◽

L. Paz-Ares

Keyword(s):

Tyrosine Kinase ◽

Second Generation ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors ◽

First And Second Generation

Mutational spectrum of acquired resistance to reversible versus irreversible EGFR tyrosine kinase inhibitors

Annals of Oncology ◽

10.1093/annonc/mdz063.032 ◽

2019 ◽

Vol 30 ◽

pp. ii51 ◽

Cited By ~ 1

Author(s):

S. Wagener-Ryczek ◽

C. Heydt ◽

J. Sueptitz ◽

S. Michels ◽

M. Falk ◽

...

Keyword(s):

Tyrosine Kinase ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Mutational Spectrum ◽

Egfr Tyrosine Kinase ◽