scholarly journals Abstract 2727: Heterodimeric IL-15 (hetIL-15) affects conventional dendritic cells and a distinct novel dendritic cell population in different mouse cancer models of breast and pancreatic cancer

2021 ◽  
Author(s):  
Vasiliki Stravokefalou ◽  
Dimitris Stellas ◽  
Sevasti Karaliota ◽  
Bethany Nagy ◽  
Theresa Guerin ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Dendritic Cells ◽  
Dendritic Cell ◽  
Cell Population ◽  
Cancer Models ◽  
Dendritic Cell Population ◽  
Mouse Cancer Models

scholarly journals Response of the Splenic Dendritic Cell Population to Malaria Infection

2004 ◽  
Vol 72 (7) ◽  
pp. 4233-4239 ◽  
Author(s):  
Andrew L. Leisewitz ◽  
Kirk A. Rockett ◽  
Bonginkosi Gumede ◽  
Margaret Jones ◽  
Britta Urban ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Dendritic Cell ◽  
Cell Population ◽  
T Cell Activation ◽  
Malaria Infection ◽  
Cell Activation ◽  
Splenic Dendritic Cell ◽  
Dendritic Cell Population

ABSTRACT Dendritic cells, particularly those residing in the spleen, are thought to orchestrate acquired immunity to malaria, but it is not known how the splenic dendritic cell population responds to malaria infection and how this response compares with the responses of other antigen-presenting cells. We investigated this question for Plasmodium chabaudi AS infection in C57BL/6 mice. We found that dendritic cells, defined here by the CD11c marker, migrated from the marginal zone of the spleen into the CD4+ T-cell area within 5 days after parasites entered the bloodstream. This contrasted with the results observed for the macrophage and B-cell populations, which expanded greatly but did not show any comparable migration. Over the same time period dendritic cells showed upregulation of CD40, CD54, and CD86 costimulatory molecules that are required for successful T-cell activation. In dendritic cells, the peak intracellular gamma interferon expression (as shown by fluorescence-activated cell sorting) was on day 5, 2 days earlier than the peak expression in B-cells or macrophages. These findings show that splenic dendritic cells are actively engaged in the earliest phase of malarial infection in vivo and are likely to be critical in shaping the subsequent immune response.

scholarly journals Migratory Dendritic Cells Transfer Antigen to a Lymph Node-Resident Dendritic Cell Population for Efficient CTL Priming

Immunity ◽  
2006 ◽  
Vol 25 (1) ◽  
pp. 153-162 ◽  
Author(s):  
Rhys S. Allan ◽  
Jason Waithman ◽  
Sammy Bedoui ◽  
Claerwen M. Jones ◽  
Jose A. Villadangos ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Lymph Node ◽  
Dendritic Cell ◽  
Cell Population ◽  
Dendritic Cell Population

scholarly journals Gender differences in dendritic cell population in nasal and oral cavity between allergic and non-allergic subjects.

2019 ◽  
Vol 143 (2) ◽  
pp. AB228
Author(s):  
Joshua K. Baguley ◽  
Shandra V. Bellinger ◽  
Hayat H. Srour ◽  
Ariel J. Stateman ◽  
Felix E. Rivera-Mariani
Keyword(s):  
Gender Differences ◽  
Dendritic Cell ◽  
Oral Cavity ◽  
Cell Population ◽  
Dendritic Cell Population

Dermal Dendritic Cell Population and Blood Vessels Are Diminished in the Skin of Systemic Sclerosis Patients

2013 ◽  
Vol 35 (4) ◽  
pp. 438-444 ◽  
Author(s):  
Ana P. de-Sá-Earp ◽  
Adriana P. do Nascimento ◽  
Sueli C. Carneiro ◽  
Luís C. Porto ◽  
Andréa Monte-Alto-Costa
Keyword(s):  
Systemic Sclerosis ◽  
Dendritic Cell ◽  
Blood Vessels ◽  
Cell Population ◽  
Dermal Dendritic Cell ◽  
Dendritic Cell Population

scholarly journals TARGETING THE Plasmodium chabaudi MSP-1(19) PROTEIN TO THE DEC205 DENDRITIC CELL POPULATION INDUCES FASTER PARASITE CLEARANCE

2013 ◽  
Vol 4 ◽  
Author(s):  
Panatieri Raquel ◽  
Da Silva Henrique ◽  
Yamamoto Marcio ◽  
Lima Maria Regina ◽  
Boscardin Silvia
Keyword(s):  
Dendritic Cell ◽  
Cell Population ◽  
Parasite Clearance ◽  
Plasmodium Chabaudi ◽  
Dendritic Cell Population

scholarly journals Integrated Cross-Species Analysis Identifies a Conserved Transitional Dendritic Cell Population

Cell Reports ◽  
2019 ◽  
Vol 29 (11) ◽  
pp. 3736-3750.e8 ◽  
Author(s):  
Rebecca Leylek ◽  
Marcela Alcántara-Hernández ◽  
Zachary Lanzar ◽  
Anja Lüdtke ◽  
Oriana A. Perez ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Cell Population ◽  
Dendritic Cell Population ◽  
Species Analysis

Therapeutic vaccination against advanced pancreatic cancer by autologous dendritic cells pulsed with a MUC1 peptide: Preclinical results of a clinical phase I trial

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e15652-e15652
Author(s):  
D. Jin ◽  
Y. Rong ◽  
W. Lou ◽  
X. Qin ◽  
W. Wu ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Dendritic Cells ◽  
Dendritic Cell ◽  
Cell Therapy ◽  
Phase I ◽  
Cancer Patients ◽  
Advanced Pancreatic Cancer ◽  
Delayed Type Hypersensitivity ◽  
Ductal Adenocarcinoma ◽  
Dendritic Cell Therapy

e15652 Background: Pancreatic ductal adenocarcinoma has a particularly poor prognosis. Therefore, novel therapeutic strategies such as immunotherapy are required. The aim of the present phase I study was to evaluate the safety, immune responses and clinical activity of a vaccine based on autologous dendritic cells (DC) pulsed with a specific MUC1 peptide in advanced pancreatic cancer patients. Methods: Five patients who had pancreatic cancer ductal adenocarcinoma expressing MUC1 in stage of III/IV were enrolled to the clinical trial. Patients underwent leukapheresis to generate dendritic cells by culture in vitro with granulocyte macrophage colony-stimulating factor and interleukin-4 for 5 days. Dendritic cells were then pulsed overnight with MUC1 peptide (GVTSAPDTRPAPGSTAPPAH) and harvested for vaccination. Dendritic cells (3×106-6×106) were injected intradermally every 2 weeks for 3–4 times. Results: All patients remained with progressive disease. Four patients developed strong T-cell IFN-γ and Granzyme B Elispot responses to the vaccine. Most interestingly, the patient who was treated with the highest number of DC(6×106) had more number of CTL than other patients and showed delayed-type hypersensitivity responses at injection sites and this patient stopped application of the analgetics. Another patient with relapsed pancreatic cancer who had finished the 4 times of vaccination and then followed 6 times of chemotherapy with Gemcitabine had a surprisingly long term of survival of 12 month. No evidence of significant treatment related toxicity or auto-immunity was observed. Conclusions: This study showed the safety and clinical response of MUC1 peptide-pulsed dendritic cell therapy for patients with advanced pancreatic cancer. It confirms the capability of this DC vaccine to stimulate an immune response in patients with pancreatic cancer even in the presence of a large tumor burden. Dendritic cell therapy is recommended for further clinical studies in pancreatic cancer patients. No significant financial relationships to disclose.

Phenotypic and functional characterization of CD11c+ dendritic cell population in mouse Peyer's patches

1996 ◽  
Vol 26 (8) ◽  
pp. 1801-1806 ◽  
Author(s):  
Christiane Ruedl ◽  
Claudia Rieser ◽  
Günther Böck ◽  
Georg Wick ◽  
Hugo Wolf
Keyword(s):  
Dendritic Cell ◽  
Cell Population ◽  
Functional Characterization ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
Dendritic Cell Population
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