Abstract A104: Phosphatase activation and kinase inhibition as a novel therapeutic strategy for pancreatic cancer

2015 ◽  
Author(s):  
Brittany L. Allen-Petersen ◽  
Amy S. Farrell ◽  
Colin J. Daniel ◽  
Zhiping Wang ◽  
Charles D. Lopez ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Therapeutic Strategy ◽  
Kinase Inhibition ◽  
Phosphatase Activation ◽  
Novel Therapeutic

A Novel Therapeutic Strategy for Pancreatic Cancer: Targeting Cell Surface Glycan Using rBC2LC-N Lectin–Drug Conjugate (LDC)

2017 ◽  
Vol 17 (1) ◽  
pp. 183-195 ◽  
Author(s):  
Osamu Shimomura ◽  
Tatsuya Oda ◽  
Hiroaki Tateno ◽  
Yusuke Ozawa ◽  
Sota Kimura ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Surface ◽  
Therapeutic Strategy ◽  
Cancer Targeting ◽  
Drug Conjugate ◽  
Novel Therapeutic

Targeting Sema3D in pancreatic cancer: A novel therapeutic strategy.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. 4129-4129
Author(s):  
Adrian Murphy ◽  
Jennifer Kleponis ◽  
Agnieszka Rucki ◽  
Elizabeth M. Jaffee ◽  
Lei Zheng ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Therapeutic Strategy ◽  
Novel Therapeutic

Nanoformulation of PROteolysis TArgeting Chimera targeting ‘undruggable’ c-Myc for the treatment of pancreatic cancer

Nanomedicine ◽  
2020 ◽  
Vol 15 (18) ◽  
pp. 1761-1777 ◽  
Author(s):  
Aishwarya Saraswat ◽  
Manali Patki ◽  
Yige Fu ◽  
Shrikant Barot ◽  
Vikas V Dukhande ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Culture ◽  
Physicochemical Properties ◽  
Therapeutic Strategy ◽  
Caspase 3 ◽  
Physical Stability ◽  
Pancreatic Cancer Cells ◽  
Nanoprecipitation Method ◽  
Apoptotic Marker ◽  
Novel Therapeutic

Aim: To explore the anticancer activity of a novel BRD4 protein degrader ARV-825 (ARV) and its nanoformulation development (ARV-NP) for treatment of pancreatic cancer. Materials & methods: ARV-NP were prepared using nanoprecipitation method and characterized for their physicochemical properties and various anticancer cell culture assays. Results: ARV-NP (89.63 ± 16.39 nm) demonstrated good physical stability, negligible hemolysis and improved half-life of ARV. ARV-NP showed significant cytotoxicity, apoptosis and anticlonogenic effect in pancreatic cancer cells. Significant downregulation of target proteins BRD4, c-Myc, Bcl-2 and upregulation of apoptotic marker cleaved caspase-3 was observed. Most importantly, ARV-NP treatment significantly inhibited the cell viability of 3D tumor spheroids of pancreatic cancer. Conclusion: ARV-NP represents a novel therapeutic strategy for pancreatic cancer.

Metabolic regulation of Ca2+ homeostasis as a novel therapeutic strategy for pancreatic cancer

Pancreatology ◽  
2016 ◽  
Vol 16 (3) ◽  
pp. S30
Author(s):  
Andrew James ◽  
Waseema Patel ◽  
Zohra Butt ◽  
Magretta Adiamah ◽  
Raga Dakhel ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Metabolic Regulation ◽  
Therapeutic Strategy ◽  
Novel Therapeutic

Combination of TRAIL and JAK-2 Downregulation: Novel Therapeutic Strategy Against Pancreatic Cancer

2012 ◽  
Vol 172 (2) ◽  
pp. 231-232
Author(s):  
V. Dudeja ◽  
S.J. Skube ◽  
G. Beyer ◽  
S. Banerjee ◽  
V. Sangwan ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Therapeutic Strategy ◽  
Novel Therapeutic

Retrovirally mediated RNA interference targeting the M2 subunit of ribonucleotide reductase: A novel therapeutic strategy in pancreatic cancer

Surgery ◽  
2004 ◽  
Vol 136 (2) ◽  
pp. 261-269 ◽  
Author(s):  
Mark S. Duxbury ◽  
Hiromichi Ito ◽  
Eric Benoit ◽  
Michael J. Zinner ◽  
Stanley W. Ashley ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Rna Interference ◽  
Ribonucleotide Reductase ◽  
Therapeutic Strategy ◽  
Novel Therapeutic

Anti-OX40ligand treatment as a novel therapeutic strategy in a murine model of colitis

2001 ◽  
Vol 120 (5) ◽  
pp. A685-A685
Author(s):  
B SINGH ◽  
V MALMSTROM ◽  
F POWRIE
Keyword(s):  
Murine Model ◽  
Therapeutic Strategy ◽  
Novel Therapeutic
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