Abstract 3927: Radium-223 α-particle radiation: Characterization of thein vitroeffects on cancer cells in monotherapy and in combination with DNA repair inhibitors

2019 ◽  
Author(s):  
Kristina Bannik ◽  
Sabine Zitzmann-Kolbe ◽  
Arne Scholz ◽  
Sabrina Jarke ◽  
Marco Jarzombek ◽  
...  
Keyword(s):  
Dna Repair ◽  
Cancer Cells ◽  
Particle Radiation ◽  
Radium 223 ◽  
Dna Repair Inhibitors

scholarly journals DNA Junction Ligands Trigger DNA Damage and Are Synthetic Lethal with DNA Repair Inhibitors in Cancer Cells

2019 ◽  
Vol 142 (1) ◽  
pp. 424-435 ◽  
Author(s):  
Katerina Duskova ◽  
Pauline Lejault ◽  
Élie Benchimol ◽  
Régis Guillot ◽  
Sébastien Britton ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Repair ◽  
Cancer Cells ◽  
Synthetic Lethal ◽  
Dna Repair Inhibitors

scholarly journals Nuclear body phase separation drives telomere clustering in ALT cancer cells

2020 ◽  
Vol 31 (18) ◽  
pp. 2048-2056 ◽  
Author(s):  
Huaiying Zhang ◽  
Rongwei Zhao ◽  
Jason Tones ◽  
Michel Liu ◽  
Robert L. Dilley ◽  
...  
Keyword(s):  
Dna Repair ◽  
Phase Separation ◽  
Cancer Cells ◽  
Nuclear Body ◽  
Promyelocytic Leukemia ◽  
Nuclear Bodies ◽  
Telomere Elongation ◽  
Alternative Lengthening ◽  
Induce Phase Separation ◽  
Induce Phase

A chemical dimerization approach is developed to induce phase separation of APB nuclear bodies involved in telomere elongation in alternative lengthening of telomeres (ALT) cancer cells. It reveals that ALT telomere-associated promyelocytic leukemia nuclear body (APB) fusion leads to telomere clustering to provide templates for homology-directed telomere synthesis, an ability that is decoupled from APB function in enriching DNA repair factors.

Pharmacological targeting of differential DNA repair, radio-sensitizes WRN-deficient cancer cells in vitro and in vivo

2021 ◽  
Vol 186 ◽  
pp. 114450
Author(s):  
Pooja Gupta ◽  
Bhaskar Saha ◽  
Subrata Chattopadhyay ◽  
Birija Sankar Patro
Keyword(s):  
Dna Repair ◽  
Cancer Cells
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