Abstract P6-14-13: New approach to nipple reconstruction: In vivo evaluation of acellular nipple-areolar complex grafts

2020 ◽  
Author(s):  
David Graham ◽  
William Heim ◽  
Vincent Caronna ◽  
Abigail Chaffin ◽  
Brooke Grasperge ◽  
...  
Keyword(s):  
Nipple Reconstruction ◽  
In Vivo Evaluation ◽  
New Approach ◽  
Nipple Areolar Complex ◽  
Areolar Complex

scholarly journals MEDPOR Nipple Implant Causing Failure of Previously Stable Breast Implant

2018 ◽  
Vol 4 ◽  
pp. 2513826X1775405
Author(s):  
Zach Zhang ◽  
Murray Allen ◽  
Kirsty U. Boyd
Keyword(s):  
Breast Reconstruction ◽  
Breast Implant ◽  
Nipple Reconstruction ◽  
Review Of The Literature ◽  
Synthetic Material ◽  
Level Of Evidence ◽  
Nipple Areolar Complex ◽  
Synthetic Materials ◽  
Areolar Complex ◽  
Pros And Cons

Reconstruction of the nipple–areolar complex usually marks the final stage of breast reconstruction in postmastectomy patients. There are many approaches to the nipple reconstruction using autologous, allogenic, and synthetic materials. However, different methods have their own pros and cons and there is no current consensus for the best technique. A review of the literature showed that there is a low level of evidence for synthetic material–based nipple reconstruction providing the best nipple projection, but it is also associated with more complication. We present a case where revision of nipple reconstruction with MEDPOR implant overlying an implant-based breast reconstruction preceded the loss of both the nipple and breast construction secondary to infection.

Areola sparing mastectomy without preservation of nipple: A clinicopathological assessment and a case series.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e12099-e12099
Author(s):  
Houpu Yang ◽  
Shu Wang ◽  
Fei Xie ◽  
Jiajia Guo ◽  
Xiaoyong Chen ◽  
...  
Keyword(s):  
Case Series ◽  
Recurrence Risk ◽  
Nipple Reconstruction ◽  
Potential Treatment ◽  
Oncological Safety ◽  
Nipple Areolar Complex ◽  
Areolar Complex ◽  
Immediate Implant ◽  
Nipple Sparing Mastectomy ◽  
Nipple Sparing

e12099 Background: Preservation of the nipple-areolar complex has gained worldwide popularity due to significantly improved cosmetic result of mastectomy, while 4% to 58% involvement of nipple and assumed increased recurrence risk made it controversial on the oncological safety of nipple sparing mastectomy. This study focuses on the oncological feasibility of areola sparing mastectomy without preservation of nipple by evaluating involvement of the areola and nipple separately in consecutive mastectomy specimens. Methods: During Aug 3, 2016 to Jan 25, 2017, consecutive specimens from women underwent traditional mastectomy were analyzed. Areolae and nipples were resected and sectioned separately. Involvement of nipple and areola and clinicopathological data were analyzed. The results of 4 patients underwent areola sparing mastectomy were studied. Results: The overall frequency of malignant involvement of the areola among the breasts was 3 of 127 (2.3%), which was significantly lower than that of the nipple (11 of 127, 8.7%, p = 0.03). In patients whose tumors were ≤3cm, outside areolar area, and without dimpling of areola or inflammatory appearance, the incidence of areolar involvement was low to zero. A total of 4 patients received areola sparing mastectomy by “nipple coring” and immediate implant based reconstruction. No patients desired nipple reconstruction. Cosmetic results were all good. Conclusions: Areolae were rarely involved in breasts with tumor ≤3cm, and without inflammatory skin, dimpling of areola or retro-areolar tumor. Areola sparing mastectomy might be oncologically safe and should be a potential treatment in selected patients.

A new approach for the in vivo evaluation of sustained release dosage forms

1989 ◽  
Vol 52 (3) ◽  
pp. 249-253
Author(s):  
P. Macheras ◽  
M. Symillides ◽  
M. Georgiacodis
Keyword(s):  
Sustained Release ◽  
Dosage Forms ◽  
In Vivo Evaluation ◽  
New Approach

scholarly journals Acellular Biologic Nipple–Areolar Complex Graft: In Vivo Murine and Nonhuman Primate Host Response Evaluation

2020 ◽  
Vol 26 (15-16) ◽  
pp. 872-885
Author(s):  
Nicholas C. Pashos ◽  
David M. Graham ◽  
Brian J. Burkett ◽  
Ben O'Donnell ◽  
Rachel A. Sabol ◽  
...  
Keyword(s):  
Nonhuman Primate ◽  
Host Response ◽  
Response Evaluation ◽  
Nipple Areolar Complex ◽  
Areolar Complex

Corrigendum to: Oleic Acid Vesicles as a New Approach for Transdermal Delivery of Econazole Nitrate: Development, Characterization, and In-vivo Evaluation in Wistar Rats

2021 ◽  
Vol 16 (2) ◽  
pp. 174-174
Author(s):  
Shivani Verma ◽  
Puneet Utreja
Keyword(s):  
Oleic Acid ◽  
Transdermal Delivery ◽  
Wistar Rats ◽  
In Vivo Evaluation ◽  
New Approach ◽  
Research Scholar ◽  
Technical University ◽  
Econazole Nitrate

The authors wish to add words “Research Scholar” and “Research Supervisor” to their affiliations [1]. The original article can be found online at https://doi.org/10.2174/1574891X15999201110212725 The corrected affiliation is: Department of Pharmaceutics, Rayat-Bahra College of Pharmacy, Hoshiarpur, Punjab 146001, India; 2Faculty of Pharma-ceutical Sciences, Department of Pharmaceutics, PCTE Group of Institutes, Ludhiana, Punjab 142021, India; 3Research Scholar, I.K. Gujral Punjab Technical University, Jalandhar-Punjab 144601, India; 4Research Supervisor, I.K. Gujral Punjab Technical University, Jalandhar-Punjab 144601, India

scholarly journals Long V-Y advancement technique for large nipple reconstruction in Asian women

2021 ◽  
Vol 48 (1) ◽  
pp. 44-48
Author(s):  
Nam Jang ◽  
Junekyu Kim ◽  
Hyun Woo Shin ◽  
Sang Woo Suk
Keyword(s):  
Donor Site ◽  
Muscle Layer ◽  
Contralateral Side ◽  
Asian Women ◽  
Nipple Reconstruction ◽  
Dermal Matrix ◽  
Nipple Areolar Complex ◽  
Areolar Complex ◽  
Complex Reconstruction ◽  
Upper Third

Previously reported nipple-areolar complex reconstruction (NAR) methods involve multiple incisions and wide skin redraping, which increase retraction forces and heighten the risk of nipple-areolar complex (NAC) flattening. We introduce a NAR method using the long V-Y advancement technique that can overcome these disadvantages. A V-shaped flap is designed with the width of the flap base 4–5 mm larger than the diameter of the normal nipple. The flap length is designed to be at least 2.5 times its width. Dissection is performed to the top of the artificial dermal matrix or muscle layer. The nipple is constructed with the same projection as the contralateral side by folding the elevated flap. The tip of the elevated flap is apposed in the middle of the donor defect to minimize the deformity during donor site closure. A 3-point skin suture is applied to the upper third of the folded flap to mold its shape. Using this long V-Y advancement technique, we successfully decreased skin tension in NAC flaps and improved the maintenance of reconstructed nipple projection. The long V-Y advancement technique provides an easy, simple NAR method, effectively maintaining longer nipple projections and reducing breast deformities, especially in Asian women with relatively large nipples.

Radiolabelling and in vivo evaluation of [11C]GSK215083 as potential PET radioligand for the 5-HT6 receptor in the porcine brain

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S598-S598 ◽  
Author(s):  
Laurent Martarello ◽  
Vincent J Cunningham ◽  
Julian C Matthews ◽  
Eugenii Rabiner ◽  
Steen Jakobsen ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
Porcine Brain
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