Abstract PO-099: Racial differences in the association of circulating inflammatory proteins with mortality from causes other than the index cancer in older adult cancer survivors in the Atherosclerosis Risk in Communities (ARIC) study

Introduction: Gender and racial differences in the association between different patterns of bundle branch block (BBB) and mortality in the general population are not well established. Methods: We used Cox proportional hazard models to evaluate the risk of all-cause mortality associated with left BBB (LBBB) and right BBB (RBBB). The study group, 15,316 participants from the Atherosclerosis Risk in Communities (ARIC) study was stratified by gender and race. We excluded the participants with other BBBs or QRS duration ≥120 ms not classified as complete RBBB or LBBB. Results: At baseline in 1987-89, mean age was 54 years, 55.3% were women, and 26.8% blacks. There were 88 LBBB and 202 RBBB. During a mean follow up of 18 years, 3,347 deaths occurred. Compared to No-BBB, LBBB was strongly associated with increased mortality in all subgroups by gender and race (Table). However, RBBB was not significantly associated with all-cause mortality in any of the subgroups in the multivariable adjusted models. Conclusions: Prevalent LBBB, but not RBBB, is a predictor of all-cause mortality in women and men as well as in blacks and whites. These findings may help in selecting patients who could benefit from further diagnostic evaluation for possible therapeutic and preventive intervention.

Download Full-text

Predictors of Racial Differences in Depression and Affect among Older adult, Long-term Cancer Survivors

Innovation in Aging ◽

10.1093/geroni/igab046.2577 ◽

2021 ◽

Vol 5 (Supplement_1) ◽

pp. 692-692

Author(s):

Gary Deimling ◽

Dyanna Burnham ◽

Gabrielle Beck

Keyword(s):

Negative Affect ◽

Cancer Survivors ◽

Racial Differences ◽

Older Adult ◽

Mood State ◽

Treatment Center ◽

Cancer Symptoms ◽

Age Related ◽

Adult Cancer Survivors

Abstract Research has long documented the psycho-social sequelae experienced by those who have been treated for and survived cancer. Depression, affect and other indicators of mood state have been an important focus of that research However, there is little research on racial differences in depression and affect outcomes or the specific cancer and age-related factors that predict them. The research to be presented is based on a 10 year, six wave NCI funded study of 471 older adult (age 60+), long-term cancer survivors randomly selected from the tumor registry of a comprehensive cancer treatment center. Key outcome measures were depression (CES-D) scale) and both positive and negative affect (PANAS). Covariance analyses and nested OLS Regression were used to identify Black-white differences these outcomes and the relative importance of both cancer and non-cancer predictors. Blacks reported lower levels of depression and negative affect when compared to whites. In a separate regression analysis of the black sub-sample, continuing cancer-related symptoms were by far the strongest predictors (beta =.16) of negative affect. In the white sub-sample, while cancer-related symptoms continued to be a significant predictor (beta=.16), non-cancer symptoms were substantially more important (beta=. 22). These results will hopefully help practitioners to have a better understanding of the nuanced racialized experiences and mental health among cancer survivors, and how these may impact after-care for older adult cancer survivors.

Download Full-text

The Landscape of Perception: Racial Differences in How Disability Is Viewed Among Older-Adult Cancer Survivors

The International Journal of Aging and Human Development ◽

10.1177/00914150211024174 ◽

2021 ◽

pp. 009141502110241

Author(s):

Spencier Ciaralli ◽

Gary T. Deimling ◽

Dyanna L. Burnham

Keyword(s):

Cancer Survivors ◽

Racial Differences ◽

Older Adult ◽

Strong Relationship ◽

Later Life ◽

Related Factors ◽

Tumor Registry ◽

Black And White ◽

Models Of Disability ◽

Adult Cancer Survivors

This paper compares disability perceptions of Black with white older cancer survivors’ to document racial disparities in these perceptions and the factors that contribute to them. The data are from a randomly selected tumor registry sample of 321 older adult cancer survivors from an NCI funded study. OLS regression models of disability perceptions, nested by race, examined the effects cancer and non-cancer health factors along with important covariates. Black older adult cancer survivors perceived themselves to be more disabled than did white survivors. Multivariate analyses showed a strong relationship between functional difficulties and disability perceptions for both Black and white survivors. However cancer-related factors such as continuing symptoms of the illness or treatment were relatively more important for Blacks. The findings suggest that race and cancer are both important factors in our understanding of disability in later life. These findings can then inform clinical best practices among minority older adults.

Download Full-text