Investigation of the Possible Role of Sialic Acid in Calcium Oxalate Urolithiasis

During the last few years, there has been relevant progress in both understanding and managing urolithiasis. Our knowledge of stone formation has changed; although the importance of urine biochemistry was questioned by several investigators years ago, the decisive role of cellular processes (induced by oxidative stress) and the renal papilla has only recently been generally accepted as the most important step in stone formation. For calcium oxalate urolithiasis, the formation of papillary calcifications plays a key role and is of prognostic relevance. Further research has to concentrate on these aspects of preventing urolithiasis. Stone prevention (metaphylaxis) is a major issue when considering the burden it places on healthcare systems. An effective metaphylaxis could lower the cost of stone therapy significantly. For uric acid urolithiasis, so far there is only preliminary information available showing that papillary plaques are not as important as they are in calcium oxalate urolithiasis. Concerning stone management, endourology has improved stone therapy significantly during the last few years. Morbidity decreased and success (stone-free) rates increased. Therefore, the indications for extracorporeal shockwave lithotripsy (ESWL) narrowed. ESWL, however, still has its place in stone therapy. There is not one single treatment modality that is equally effective for all situations. It is important to observe the differential indications for different stones depending on size, localization, and composition.

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Prophylactic role of Boerhaavia diffusa in ethylene glycol induced calcium oxalate urolithiasis

African Journal of Urology ◽

10.1007/s12301-011-0007-1 ◽

2011 ◽

Vol 17 (2) ◽

pp. 28-36 ◽

Cited By ~ 3

Author(s):

Surendra K. Pareta ◽

K. C. Patra ◽

P. M. Mazumder ◽

D. Sasmal

Keyword(s):

Ethylene Glycol ◽

Calcium Oxalate ◽

Calcium Oxalate Urolithiasis ◽

Boerhaavia Diffusa

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The Role of Magnesium in Calcium Oxalate Urolithiasis

The Journal of Urology ◽

10.1016/s0022-5347(17)41541-2 ◽

1988 ◽

Vol 140 (1) ◽

pp. 211-211

Author(s):

K. Kohri ◽

J. Garside ◽

N.J. Blacklock

Keyword(s):

Calcium Oxalate ◽

Calcium Oxalate Urolithiasis

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Dietary Restriction: A Major Factor in Prophylaxis against Calcium Oxalate Urolithiasis

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v9i6.3716 ◽

2019 ◽

Vol 9 (6) ◽

pp. 126-129

Author(s):

Kamel El-Reshaid ◽

Shaikha Al-Bader

Keyword(s):

Calcium Oxalate ◽

Stone Formation ◽

Renal Stones ◽

High Water ◽

Metabolic Derangement ◽

Calcium Oxalate Urolithiasis ◽

Urinary Tract Stones ◽

High Water Intake

Urolithiasis (Ur) Is A Worldwide Problem That Affects All Groups Of Ages. Nearly 80% Of Renal Stones Are Calcium Oxalate (Cao) And 50% Of The Affected Patients Have Recurrent Disease Within 10 Years. Our Prospective Study Was Conducted Over 4 And ½ Years And Evaluated The Role Of Dietary Manipulation In Prophylaxis Against Cao Ur. A Total Of 212 Patients With Recurrent Cao Ur, Who Lacked Anatomical Or Metabolic Derangement, Were Subjected To A Practical And Specific Diet. The Latter Had: (A) Low Salt, Red-Meat And Green Leafy Vegetable, (B) Moderate Amounts Of Milk, Dairy Products, Poultry And Certain Fish-Items, And (C) High Water Intake (2 Liters/Day). A Total Of 66/70 (96%), 87/108(88%) And 146/167(87.4%) Patients Were Stone-Free By The End Of 1, 2 And 3 Years Of Follow Up. The Median Time For Stone-Free Duration Was 33 (28.7-37.3) Months. Adding A Thiazide And Allopurinol To The 19 Patients Who Had Failed Dietary Prophylaxis Prevented Stone Formation In 16 More Patients Leaving Only 3 True Failures. Four Patients Could Not Tolerate The Latter 2 Drugs For Allergy. In Conclusion; Our Practical Dietary Modification Can Aid In Prophylaxis Against Cao Ur. Keywords: Diet, Calcium Oxalate, Urolithiasis, Urinary Tract Stones, Prophylaxis

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