Decrease in Brain Cytochrome P450 Enzyme Activities during Infection and Inflammation of the Central Nervous System

2000 ◽  
Vol 8 (3) ◽  
pp. 142-147 ◽  
Author(s):  
Mario Monshouwer ◽  
Davide Agnello ◽  
Pietro Ghezzi ◽  
Pia Villa
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cytochrome P450 ◽  
Enzyme Activities ◽  
Cytochrome P450 Enzyme ◽  
P450 Enzyme ◽  
Infection And Inflammation ◽  
The Central Nervous System

Regulation of cytochrome P450 in the central nervous system

1993 ◽  
Vol 47 (1-6) ◽  
pp. 191-194 ◽  
Author(s):  
Margaret Warner ◽  
Maria Strömstedt ◽  
Adrian Wyss ◽  
Jan-Åke Gustafsson
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cytochrome P450 ◽  
The Central Nervous System

Microsomal cytochrome P450 enzyme activities in nonalcoholic steatohepatitis livers

2019 ◽  
Vol 34 (1) ◽  
pp. S25
Author(s):  
Maciej Czerwinski ◽  
Brian Oberheide ◽  
Nicholas Hatfield ◽  
Bill Ewy ◽  
Christopher Seib ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Nonalcoholic Steatohepatitis ◽  
Enzyme Activities ◽  
Cytochrome P450 Enzyme ◽  
Microsomal Cytochrome ◽  
P450 Enzyme ◽  
Microsomal Cytochrome P450

Effects of Methoxychlor and 2,2-bis (p-Hydroxyphenyl)-1,1,1-Trichloroethane on Cytochrome P450 Enzyme Activities in Human and Rat Livers

Pharmacology ◽  
2015 ◽  
Vol 95 (3-4) ◽  
pp. 145-153 ◽  
Author(s):  
Bingbing Chen ◽  
Peipei Pan ◽  
Li Wang ◽  
Menchun Chen ◽  
Yaoyao Dong ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Enzyme Activities ◽  
Cytochrome P450 Enzyme ◽  
P450 Enzyme ◽  
Rat Livers

Inhibitory effects of astaxanthin, β-cryptoxanthin, canthaxanthin, lutein, and zeaxanthin on cytochrome P450 enzyme activities

2013 ◽  
Vol 59 ◽  
pp. 78-85 ◽  
Author(s):  
Yu Fen Zheng ◽  
Soo Hyeon Bae ◽  
Min Jo Kwon ◽  
Jung Bae Park ◽  
Hye Duck Choi ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Enzyme Activities ◽  
Cytochrome P450 Enzyme ◽  
Inhibitory Effects ◽  
P450 Enzyme

scholarly journals Cytochrome P450 (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

2019 ◽  
Vol 2019 (4) ◽  
Author(s):  
Kathryn Burns ◽  
Nuala Ann Helsby
Keyword(s):  
Cytochrome P450 ◽  
Enzyme Activities ◽  
Significant Proportion ◽  
Cytochrome P450 Enzyme ◽  
Physiological Processes ◽  
P450 Enzyme ◽  
The Individual ◽  
Fat Soluble Vitamins ◽  
Extensive Family ◽  
Cyp450 Enzyme

The cytochrome P450 enzyme family (CYP450), E.C. 1.14.-.-, were originally defined by their strong absorbance at 450 nm due to the reduced carbon monoxide-complexed haem component of the cytochromes. They are an extensive family of haem-containing monooxygenases with a huge range of both endogenous and exogenous substrates. These include sterols, fat-soluble vitamins, pesticides and carcinogens as well as drugs. The substrates of some orphan CYP are not known. Listed below are the human enzymes; their relationship with rodent CYP450 enzyme activities is obscure in that the species orthologue may not catalyse the metabolism of the same substrates. Although the majority of CYP450 enzyme activities are concentrated in the liver, the extrahepatic enzyme activities also contribute to patho/physiological processes. Genetic variation of CYP450 isoforms is widespread and likely underlies a significant proportion of the individual variation to drug administration.

Serotonin syndrome in a Parkinson disease patient after intake of an ethanol-containing homeopathic medication

2020 ◽  
Vol 10 (4) ◽  
pp. 219-222 ◽  
Author(s):  
Cezar Thomas R Suratos ◽  
Mark M Del Rosario ◽  
Roland Dominic G Jamora
Keyword(s):  
Nervous System ◽  
Cytochrome P450 ◽  
Parkinson Disease ◽  
Serotonin Syndrome ◽  
Enzyme System ◽  
Disease Patient ◽  
Cytochrome P450 Enzyme ◽  
Parkinson Disease Patient ◽  
P450 Enzyme ◽  
Cytochrome P450 Enzyme System

Serotonin syndrome is due to excess serotonin in the nervous system. We document a case of an elderly Parkinson disease patient who has been neurologically stable on rasagiline and escitalopram for 1 year but developed serotonin syndrome after intake of an ethanol-containing homeopathic medication. The patient presented with seizures, autonomic dysfunction and neuromuscular hyperexcitability. Maintenance medications were discontinued, hydration, sedation and respiratory support were provided with resolution of the symptoms. The combination of escitalopram and ethanol, both metabolized by the cytochrome P450 enzyme system can lead to serotonin syndrome. Our case highlights the importance of drug interactions in patients taking several medications. Additionally, the intake of medicines, may it be conventional or homeopathic medicine, without the guidance of a trained and competent physician, may lead to serious consequences for the patient.

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