Activation of Capsaicin Receptors on the Sciatic Nerve Induces FOS Expression in the Spinal Dorsal Horn of Adult Rats

Neurosignals ◽  
2002 ◽  
Vol 11 (3) ◽  
pp. 151-157 ◽  
Author(s):  
Yu-Peng Feng ◽  
Kun Yang ◽  
Yun-Qing Li
Keyword(s):  
Sciatic Nerve ◽  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Adult Rats ◽  
Spinal Dorsal ◽  
Fos Expression

scholarly journals Early Changes in Homer1 Proteins in the Spinal Dorsal Horn Are Associated with Loose Ligation of the Rat Sciatic Nerve

2009 ◽  
Vol 109 (6) ◽  
pp. 2000-2007 ◽  
Author(s):  
Gordana Miletic ◽  
Ashley M. Driver ◽  
Takako Miyabe-Nishiwaki ◽  
Vjekoslav Miletic
Keyword(s):  
Sciatic Nerve ◽  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Spinal Dorsal ◽  
Rat Sciatic Nerve

Endomorphin-1 reduces carrageenan-induced Fos expression in the rat spinal dorsal horn

Neuropeptides ◽  
1999 ◽  
Vol 33 (4) ◽  
pp. 281-284 ◽  
Author(s):  
S.-X. Jin ◽  
L.-G. Lei ◽  
Y. Wang ◽  
D.-F. Da ◽  
Z.-Q. Zhao
Keyword(s):  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Spinal Dorsal ◽  
Fos Expression

The NMDA antagonist MK801 reduces noxious stimulus-evoked fos expression in the spinal dorsal horn

Pain ◽  
1990 ◽  
Vol 41 ◽  
pp. S165 ◽  
Author(s):  
L.J. Kehl ◽  
A.I. Basbaum ◽  
C.H. Pollock ◽  
M. Mayes ◽  
G.L. Wilcox
Keyword(s):  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Nmda Antagonist ◽  
Noxious Stimulus ◽  
Spinal Dorsal ◽  
Fos Expression

scholarly journals Loose ligation of the rat sciatic nerve elicits early accumulation of Shank1 protein in the post-synaptic density of spinal dorsal horn neurons

Pain ◽  
2010 ◽  
Vol 149 (1) ◽  
pp. 152-159 ◽  
Author(s):  
Gordana Miletic ◽  
Catalina I. Dumitrascu ◽  
Christopher E. Honstad ◽  
Daniela Micic ◽  
Vjekoslav Miletic
Keyword(s):  
Sciatic Nerve ◽  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Synaptic Density ◽  
Dorsal Horn Neurons ◽  
Spinal Dorsal ◽  
Rat Sciatic Nerve ◽  
Spinal Dorsal Horn Neurons ◽  
Post Synaptic Density

scholarly journals Upregulation of Spinal ASIC1 and NKCC1 Expression Contributes to Chronic Visceral Pain in Rats

2021 ◽  
Vol 13 ◽  
Author(s):  
Yong-Chang Li ◽  
Yuan-Qing Tian ◽  
Yan-Yan Wu ◽  
Yu-Cheng Xu ◽  
Ping-An Zhang ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Signaling Pathway ◽  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Visceral Pain ◽  
Intrathecal Injection ◽  
Adult Rats ◽  
Sodium Potassium ◽  
Spinal Dorsal ◽  
Whole Cell Patch Clamp

Aims: To determine whether acid-sensing ion channel 1 (ASIC1)–sodium-potassium-chloride cotransporter 1 (NKCC1) signaling pathway participates in chronic visceral pain of adult rats with neonatal maternal deprivation (NMD).Methods: Chronic visceral pain was detected by colorectal distension (CRD). Western blotting and Immunofluorescence were performed to detect the expression and location of ASIC1 and NKCC1. Whole-cell patch-clamp recordings were performed to record spinal synaptic transmission.Results: The excitatory synaptic transmission was enhanced and the inhibitory synaptic transmission was weakened in the spinal dorsal horn of NMD rats. ASIC1 and NKCC1 protein expression in the spinal dorsal horn was significantly up-regulated in NMD rats. Incubation of Amiloride reduced the amplitude of mEPSCs. Incubation of Bumetanide (BMT) increased the amplitude of mIPSCs. Intrathecal injection of ASIC1 or NKCC1 inhibitors reversed the threshold of CRD in NMD rats. Also, Amiloride treatment significantly reversed the expression of NKCC1 in the spinal dorsal horn of NMD rats.Conclusion: Our data suggest that the ASIC1-NKCC1 signaling pathway is involved in chronic visceral pain in NMD rats.

Sign in / Sign up

Export Citation Format

Share Document