Rapid Effects of a Single High Dose of Simvastatin on C-Reactive Protein in Patients with Unstable Angina

Heart Drug ◽  
2005 ◽  
Vol 5 (3) ◽  
pp. 140-145 ◽  
Author(s):  
Jian-Jun Li ◽  
Chun-Hong Fang ◽  
Ming-Zhe Chen ◽  
Xin Chen
Keyword(s):  
Unstable Angina ◽  
High Dose ◽  
C Reactive Protein ◽  
Single High Dose ◽  
Reactive Protein

The Prognostic Value of C-Reactive Protein and Serum Amyloid A Protein in Severe Unstable Angina

1994 ◽  
Vol 331 (7) ◽  
pp. 417-424 ◽  
Author(s):  
Giovanna Liuzzo ◽  
Luigi M. Biasucci ◽  
J. Ruth Gallimore ◽  
Rita L. Grillo ◽  
Antonio G. Rebuzzi ◽  
...  
Keyword(s):  
Unstable Angina ◽  
Prognostic Value ◽  
Serum Amyloid A ◽  
Serum Amyloid ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Amyloid A ◽  
Serum Amyloid A Protein

scholarly journals INDICATORS OF INFLAMMATION IN THE PATHOGENESIS OF UNSTABLE ANGINA

2020 ◽  
Vol 73 (3) ◽  
pp. 569-573 ◽  
Author(s):  
Yevheniia H. Zaremba ◽  
Olha V. Smaliukh ◽  
Olena V. Zaremba-Fedchyshyn ◽  
Olha V. Zaremba ◽  
Andriy S. Kost ◽  
...  
Keyword(s):  
Unstable Angina ◽  
Inflammatory Cytokines ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Low Density ◽  
C Reactive Protein ◽  
Low Density Lipoprotein Cholesterol ◽  
Reactive Protein ◽  
Lipid Spectrum

The aim: Research of blood lipid spectrum, level of anti-inflammatory cytokines and C-reactive protein of coronary heart disease patients. Materials and methods: There was examined 61 patients with unstable angina, who had been on hospital care in the cardiology department of the Lviv National Emergency Hospital. Their average age was 68.3 ± 1.9 years. The control group included 20 generally healthy persons. There was estimated blood lipid spectrum, C-reactive protein, fibrinogen and proinflammatory cytokine of patients. Results: There was determined considerable increase total cholesterol, low density lipoprotein cholesterol, very low density lipoprotein cholesterol, triglycerides and coefficient of atherogenicity. High level of C-reactive protein and pro-inflammatory cytokines were detected in patients with unstable angina. Conclusions: In patients with unstable angina was revealed a significant increase of proinflammatory cytokines levels in the blood serum: interleukin-1β, interleukin-6, interleukin-17, TNF-α and C-reactive protein, fibrinogen, which indicates activation of the inflammatory process. In patients with unstable angina was detected a significant disorder of blood lipid spectrum. For its correction should be recommended diet and hypolipidemic agents.

scholarly journals Racial/ethnic Disparities on Inflammation and Response to Methylprednisolone in Severe Covid-19 Pneumonia

2021 ◽  
Author(s):  
Ronaldo C. Go ◽  
Themba Nyirenda ◽  
Maryam Bojarian ◽  
Davood Karimi Hosseini ◽  
Kevin Kim ◽  
...  
Keyword(s):  
Inflammatory Markers ◽  
Asian Indians ◽  
Low Dose ◽  
Ethnic Disparities ◽  
Prolonged Survival ◽  
High Dose ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
High Dose Methylprednisolone ◽  
Racial Ethnic

Abstract BACKGROUNDRacial/Ethnic minorities are at higher risk for Severe COVID-19. This may be related to social determinants that lead to chronic inflammatory states. The aims of the study were to determine if there are racial/ethnic differences between the inflammatory markers of survivors and non-survivors and if there was a dose dependent association of methylprednisolone to in hospital survival. METHODSThis was a secondary analysis of a retrospective cohort. Patients were older than 18 years of age and admitted for severe COVID-19 Pneumonia Between March to June 2020 in 13 Hospitals in New Jersey, United States. Comparison of inflammatory markers used Kruskal-Wallis followed by pairwise comparison using two-sided Wilcoxon rank sum test. A Youden Index Method was used to determine the cut-off between low dose and high dose methylprednisolone. For each racial/ethnic group, cox regression was used to determine the association to survival between no methylprednisolone and methylprednisolone (high dose versus low dose). RESULTSPropensity matched sample (n=759) between no methylprednisolone (n=380) and methylprednisolone (n=379) had 338 Whites, 102 Blacks, 61 Asian/Indians, and 251 Non-Black Non-White Hispanics. Interleukin-6, C-reactive protein, ferritin, and d-dimer values were higher in non-survivors compared to survivors except in Asian/Indian survivors who had higher ferritin values compared to non-survivors (median: 1,265 vs 418 ug/L, P=0.0211). Black and Hispanic survivors had persistently elevated C-reactive protein, (10.2 mg/mL) and (13.70 mg/mL) respectively. Low dose methylprednisolone was associated with prolonged 60 days in hospital survival over no methylprednisolone in Whites (P<0.0001), Asian/Indians (P=0.0180), and Hispanics (P=0.0004). Regardless of dose, methylprednisolone was not associated with prolonged survival in Blacks. High dose methylprednisolone was associated with worse survival in Hispanics. (P=0.0181). CONCLUSIONRacial/Ethnic disparities with inflammatory markers in survivors and non-survivors preclude the use of one marker as predictor of survival. Low dose methylprednisolone is associated with prolonged survival in Asian/Indians, Hispanics, and Whites. Methylprednisolone, regardless of dose, was not associated with prolonged survival in Blacks.

Enhanced inflammatory response of blood monocytes to C-reactive protein in patients with unstable angina

2005 ◽  
Vol 352 (1-2) ◽  
pp. 127-133 ◽  
Author(s):  
Jian-Jun Li ◽  
Hai-Rong Wang ◽  
Cong-Xin Huang ◽  
Jia-Lin Xue ◽  
Geng-Shan Li
Keyword(s):  
Inflammatory Response ◽  
Unstable Angina ◽  
Blood Monocytes ◽  
C Reactive Protein ◽  
Reactive Protein

THU0309 UNILATERAL TEMPORAL ARTERY BIOPSY IS SUFFICIENT FOR DIAGNOSING GIANT CELL ARTERITIS IF THE SERUM C-REACTIVE PROTEIN LEVEL IS 10 MG/DL OR HIGHER

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 383-384
Author(s):  
T. Kise ◽  
E. Takamasu ◽  
Y. Miyoshi ◽  
N. Yokogawa ◽  
K. Shimada
Keyword(s):  
Giant Cell Arteritis ◽  
Giant Cell ◽  
Temporal Artery ◽  
High Dose ◽  
Temporal Artery Biopsy ◽  
C Reactive Protein ◽  
Positive Group ◽  
Reactive Protein ◽  
Discordance Rate ◽  
Serum Crp

Background:Temporal artery biopsy (TAB) is the gold standard for diagnosing giant cell arteritis (GCA). However, previous studies have reported that the discordance rate of TAB is 3-45%,i.e., in unliteral TAB, GCA may be overlooked in one in five patients, approximately. Evidence as to whether bilateral TAB should be performed initially or one-sided TAB is sufficient for diagnosing GCA is lacking.Objectives:To investigate the predictors of patients with GCA in whom one-sided TAB is sufficient.Methods:The present study was a cross-sectional, single center study conducted from April 1, 2011 to July 31, 2019 at Tokyo Metropolitan Tama Medical Center. Of all consecutive GCA cases for which bilateral TAB was performed, bilaterally positive cases and unilaterally positive cases were extracted as bilateral positive group (BPG) and unilateral positive group (UPG), respectively. GCA was defined in accordance with the classification criteria of the 1990 American College of Rheumatology, and GCA was diagnosed if no other etiology was found within six months after beginning of high-dose glucocorticoid treatment. Demographic, clinical and laboratory data were obtained from the medical records, and the BPG and the UPG were compared statistically in each variable. Statistical significance was defined asp< 0.05.Results:During study, 264 biopsies were performed for 145 cases, who suspected GCA and underwent TAB. The pathological positivity rate was 26.1% (68 / 264 biopsies). Of these, 53 cases had final diagnosis of GCA, in which 43 cases were biopsy proven GCA. Thirty-seven biopsy proven GCA with bilateral TAB were enrolled; 64.9% women; mean (SD) age 75 (8.9) years; median [IQR] TAB length 17.5 [13.0,20.0] mm; headache 54.1%; jaw claudication 45.9%; scalp tenderness 16.2%; temporal artery (TA) tenderness 32.4%; TA engorgement 32.4%; TA pulse abnormality 5.4%; visual symptoms 2.7%; a fever of 38.5°C or higher 40.5%; shoulder girdle pain 48.6%; imaging of aortitis or arteritis 40.5%; median [IQR] white blood cell 9,100 [7200, 12050] /μl; median [IQR] platelet cell 37.5 [27.0, 46.3] ×104/μl; median [IQR] C-reactive protein (CRP) 10.1 [3.9, 16.5] mg/dL; erythrocyte sedimentation rate [IQR] 105 [66, 129] mm/h. Thirty-one in 37 cases were positive bilaterally while 6 in 37 cases were positive unilaterally; and the discordance rate was 16.2%. The median sample length after formalin fixation was 19.0 mm for the BPG and 14.5 mm for the UPG (p= 0.171). The parameters above were compared between UPG and BPG. Of these, only the serum CRP value (mg/dL) differed statistically between groups, and the median value of the two groups was 10.6 and 6.5, respectively (median test:p= 0.031). To predict BPG, in whom unilateral TAB is sufficient for diagnosing GCA, the cut-off value of serum CRP with a specificity of 100% and a sensitivity of 61.3% was set at 9.3 mg/dL (ROC analysis: AUC 0.726).Conclusion:When the serum CRP level is 10 mg/dL or higher in GCA suspected patients, an unilateral TAB alone was sufficient for an accurate diagnosis.References:[1]Hellmich, B, et al.Ann Rheum Dis2020;79(1):19-30.[2]Breuer, GS, et al.J Rheumatol. 2009;36(4):794-796.[3]Czyz CN, et al.Vascular2019;27(4):347-351.[4]Durling B, et al.Can J Ophthalmol2014;49(2):157-161.Figure.Comparison of median CRP levels between unilaterally positive group and bilaterally positive group.Disclosure of Interests:None declared

Effect of beta blockers on expression of interleukin-6 and C-reactive protein in patients with unstable angina pectoris

2001 ◽  
Vol 88 (4) ◽  
pp. 422-424 ◽  
Author(s):  
Young-Cheoul Doo ◽  
Doo-Man Kim ◽  
Dong-Jin Oh ◽  
Kyu Hyung Ryu ◽  
Chong-Yun Rhim ◽  
...  
Keyword(s):  
Angina Pectoris ◽  
Unstable Angina ◽  
Interleukin 6 ◽  
Beta Blockers ◽  
Unstable Angina Pectoris ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Prognostic value of C-reactive protein in diabetic patients with unstable angina

2003 ◽  
Vol 41 (6) ◽  
pp. 346
Author(s):  
Javier N. Guetta ◽  
Juan J. Fuselli ◽  
Carlos P. Boissonnet ◽  
Enrique Fairman ◽  
Alfredo Piombo ◽  
...  
Keyword(s):  
Unstable Angina ◽  
Prognostic Value ◽  
Diabetic Patients ◽  
C Reactive Protein ◽  
Reactive Protein
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