Purkinje Cell Loss in the Cerebellar Flocculus in Patients with Ataxia with Ocular Motor Apraxia Type 1/Early-Onset Ataxia with Ocular Motor Apraxia and Hypoalbuminemia

2007 ◽  
Vol 59 (1-2) ◽  
pp. 18-23 ◽  
Author(s):  
Masashiro Sugawara ◽  
Chizu Wada ◽  
Satoshi Okawa ◽  
Michio Kobayashi ◽  
Masato Sageshima ◽  
...  
Keyword(s):  
Purkinje Cell ◽  
Early Onset ◽  
Cell Loss ◽  
Ocular Motor ◽  
Early Onset Ataxia ◽  
Purkinje Cell Loss ◽  
Cerebellar Flocculus ◽  
Motor Apraxia

Immunological abnormalities in patients with early-onset ataxia with ocular motor apraxia and hypoalbuminemia

2021 ◽  
pp. 108776
Author(s):  
Tamaki Kato ◽  
Yoshiteru Tamura ◽  
Hiroshi Matsumoto ◽  
Osamu Kobayashi ◽  
Hideaki Ishiguro ◽  
...  
Keyword(s):  
Early Onset ◽  
Ocular Motor ◽  
Early Onset Ataxia ◽  
Motor Apraxia ◽  
Immunological Abnormalities

scholarly journals Genotype–phenotype correlations in early onset ataxia with ocular motor apraxia and hypoalbuminaemia

Brain ◽  
2011 ◽  
Vol 134 (5) ◽  
pp. 1387-1399 ◽  
Author(s):  
Akio Yokoseki ◽  
Tomohiko Ishihara ◽  
Akihide Koyama ◽  
Atsushi Shiga ◽  
Mitsunori Yamada ◽  
...  
Keyword(s):  
Early Onset ◽  
Ocular Motor ◽  
Early Onset Ataxia ◽  
Motor Apraxia

Novel splice variants increase molecular diversity of aprataxin, the gene responsible for early-onset ataxia with ocular motor apraxia and hypoalbuminemia

2004 ◽  
Vol 366 (2) ◽  
pp. 120-125 ◽  
Author(s):  
Makito Hirano ◽  
Tomohisa Nishiwaki ◽  
Shingo Kariya ◽  
Yoshiko Furiya ◽  
Makoto Kawahara ◽  
...  
Keyword(s):  
Early Onset ◽  
Molecular Diversity ◽  
Splice Variants ◽  
Ocular Motor ◽  
Early Onset Ataxia ◽  
Motor Apraxia

Early-onset ataxia with ocular motor apraxia and hypoalbuminemia: The aprataxin gene mutations

Neurology ◽  
2002 ◽  
Vol 59 (4) ◽  
pp. 590-595 ◽  
Author(s):  
H. Shimazaki ◽  
Y. Takiyama ◽  
K. Sakoe ◽  
K. Ikeguchi ◽  
K. Niijima ◽  
...  
Keyword(s):  
Early Onset ◽  
Gene Mutations ◽  
Ocular Motor ◽  
Early Onset Ataxia ◽  
Motor Apraxia

Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene

2001 ◽  
Vol 29 (2) ◽  
pp. 184-188 ◽  
Author(s):  
Hidetoshi Date ◽  
Osamu Onodera ◽  
Hajime Tanaka ◽  
Kiyoshi Iwabuchi ◽  
Kazutoshi Uekawa ◽  
...  
Keyword(s):  
Early Onset ◽  
Ocular Motor ◽  
Early Onset Ataxia ◽  
Motor Apraxia

scholarly journals Autistic-Like Behaviors, Oxidative Stress Status, and Histopathological Changes in Cerebellum of Valproic Acid Rat Model of Autism Are Improved by the Combined Extract of Purple Rice and Silkworm Pupae

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Nartnutda Morakotsriwan ◽  
Jintanaporn Wattanathorn ◽  
Woranan Kirisattayakul ◽  
Kowit Chaisiwamongkol
Keyword(s):  
Oxidative Stress ◽  
Valproic Acid ◽  
Purkinje Cell ◽  
Rat Model ◽  
Cell Loss ◽  
Hot Plate ◽  
Hot Plate Test ◽  
Silkworm Pupae ◽  
Oxidative Stress Status ◽  
Purkinje Cell Loss

Due to the crucial role of oxidative stress on the pathophysiology of autism and the concept of synergistic effect, the benefit of the combined extract of purple rice and silkworm pupae (AP1) for autism disorder was the focus. Therefore, we aimed to determine the effect of AP1 on autistic-like behaviors, oxidative stress status, and histopathological change of cerebellum in valproic acid (VPA) rat model of autism. VPA was injected on postnatal day (PND) 14 and the animals were orally given AP1 at doses of 50, 100, and 200 mg·kg−1BW between PND 14 and PND 40. The autism-like behaviors were analyzed via hot-plate, rotarod, elevated plus-maze, learning, memory, and social behavior tests. Oxidative stress and the histological change in the cerebellum were assessed at the end of study. AP1 treated rats improved behaviors in all tests except that in hot-plate test. The improvement of oxidative stress and Purkinje cell loss was also observed in the cerebellum of VPA-treated rats. Our data suggest that AP1 partially reduced autism-like behaviors by improving oxidative stress and Purkinje cell loss. Further research is required to identify the active ingredients in AP1 and gender difference effect.

Reply: Purkinje cell loss in essential tremor

2014 ◽  
Vol 29 (10) ◽  
pp. 1330-1331 ◽  
Author(s):  
Holly A. Shill ◽  
Charles H. Adler ◽  
Joseph G. Hentz
Keyword(s):  
Purkinje Cell ◽  
Essential Tremor ◽  
Cell Loss ◽  
Purkinje Cell Loss
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