Differential Effect of Central versus Parenteral Administration of Morphine Sulf ate on Regional Concentrations of Reduced Glutathione in Rat Brain

Pharmacology ◽  
1997 ◽  
Vol 54 (2) ◽  
pp. 92-97 ◽  
Author(s):  
Leonidas C. Goudas ◽  
Daniel B. Carr ◽  
Iwona Maszczynska ◽  
James E. Marchand ◽  
Heinrich Wurm ◽  
...  
2014 ◽  
Vol 66 (3) ◽  
pp. 1075-1081
Author(s):  
Ivan Simic ◽  
Violeta Iric-Cupic ◽  
Rada Vucic ◽  
Marina Petrovic ◽  
Violeta Mladenovic ◽  
...  

The aim of the present study was to evaluate the subchronic effects of 3,4-methylenedioxymethamphetamine on several oxidative stress markers: index of lipid peroxidation (ILP), superoxide dismutase (SOD) activity, superoxide radical (O2.-) levels, and reduced glutathione (GSH) levels in the frontal cortex, striatum and hippocampus of the rat. The study included 64 male Wistar rats (200-250g). The animals were treated per os with of 5, 10, or 20 mg/kg of 3,4-methylenedioxymethamphetamine (MDMA) every day for 15 days. The subchronic administration of MDMA resulted in an increase in ILP, SOD and O2.-, and a decrease in GSH, from which we conclude that oxidative stress was induced in rat brain.


1980 ◽  
Vol 30 ◽  
pp. 188
Author(s):  
Yasuhiro Nishibe ◽  
Yoshikazu Matsuo ◽  
Toshio Yoshizaki ◽  
Masami Eigyo ◽  
Teruo Shloini ◽  
...  

2006 ◽  
Vol 83 (4) ◽  
pp. 656-667 ◽  
Author(s):  
Oscar A. Bizzozero ◽  
Jennifer L. Ziegler ◽  
Gisela De Jesus ◽  
Federico Bolognani

1979 ◽  
Vol 32 (6) ◽  
pp. 1621-1627 ◽  
Author(s):  
Jaroslava Folbergrová ◽  
Stig Rehncrona ◽  
Bo K. Siesjö

Endocrinology ◽  
1994 ◽  
Vol 135 (2) ◽  
pp. 583-588 ◽  
Author(s):  
B Mellström ◽  
C Pipaón ◽  
J R Naranjo ◽  
A Perez-Castillo ◽  
A Santos

1999 ◽  
Vol 35 (4) ◽  
pp. 337-343 ◽  
Author(s):  
M.N Subhash ◽  
K.Y Vinod ◽  
B.N Srinivas

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