Age-Related Histochemical and Histological Changes in the Knee-Joint Cartilage of C57B1 Mice and Their Significance for the Pathogenesis of Osteoarthrosis

Pathobiology ◽  
1980 ◽  
Vol 48 (5) ◽  
pp. 329-348 ◽  
Author(s):  
A. Pataki ◽  
J.R. Rüttner ◽  
K. Abt
2021 ◽  
Vol 7 (4) ◽  
pp. 400-407
Author(s):  
Xiaofeng Zhang

Objectives: By analyzing the protective effect and mechanism of tobacco on knee joint cartilage in rats, this paper studies the effect of tobacco on knee joint recovery of college students after sports. Methods: Firstly, the main subunits of nAChRs were systematically studied by using the rat knee arthritis model α 7 and α 4 and β To clarify the correlation between nAChRs and the occurrence and development of OA. Then, the OA rat model prepared by iodoacetic acid was used as the experimental object to observe the protective effect of nicotine on knee osteoarthritis cartilage in rats. Results: The histological changes of rats in MIA group were obvious after operation. The results of light microscope score and Mankin's score at 15 and 30 days were significantly higher than those in con group. Of right knee cartilage in rats in MIA group α 7, α 4 and β The expression of 2 did not change significantly on the 15th day, but increased significantly on the 30th day compared with the blank control group. Conclusion: Nicotine has a protective effect on knee bone and joint cartilage and promotes the accelerated recovery of knee bone and joint after exercise.. Key words: nicotine, knee joint, cartilage, recovery after exercise.


2001 ◽  
Vol 44 (11) ◽  
pp. 2556-2561 ◽  
Author(s):  
M. Hudelmaier ◽  
C. Glaser ◽  
J. Hohe ◽  
K.-H. Englmeier ◽  
M. Reiser ◽  
...  

2014 ◽  
Vol 76 (2) ◽  
pp. 277-280 ◽  
Author(s):  
Akira YABUKI ◽  
Shinichiro YONESHIGE ◽  
Shin TANAKA ◽  
Masashi TSUJIO ◽  
Sawane MITANI ◽  
...  

Author(s):  
Patricia M. Lutz ◽  
Matthias J. Feucht ◽  
Judith Wechselberger ◽  
Michael Rasper ◽  
Wolf Petersen ◽  
...  

Abstract Purpose Ultrasound (US) examination of the medial joint space of the knee has played a subordinate diagnostic role up till now. The purpose of the present study was to describe mean values of medial joint width and to investigate the impact of gender, age, and body mass index (BMI) on medial joint laxity in healthy knees using modern, dynamic US in a standardized fashion in unloaded and standardized loaded conditions. Methods A total of 65 subjects with 79 healthy knees were enrolled in this study. All volunteers underwent clinical examination of the knee. The medial knee joint width was determined using US in a supine position at 0° and 30° of knee flexion in unloaded and standardized loaded (= 15 Dekanewton, daN) conditions using a specific device. Mean values were described and correlations between medial knee joint width and gender, age, and BMI were assessed. Results Thirty-two females and 33 males were enrolled in this study. The mean medial joint width in 0° unloaded was 5.7 ± 1.2 mm and 7.4 ± 1.4 mm loaded. In 30° of knee flexion, the mean medial joint width was 6.1 ± 1.1 mm unloaded and 7.8 ± 1.2 mm loaded. The average change between unloaded and loaded conditions in 0° was 1.7 ± 1.0 mm and in 30° 1.7 ± 0.9 mm. A significant difference between genders was evident for medial joint width in 0° and 30° of flexion in unloaded and loaded conditions (p < 0.05). With rising age, a significant increased change of medial joint space width between unloaded and loaded conditions could be demonstrated in 0° (p = 0.032). No significant correlation between BMI and medial joint width in US could be found. Conclusion Mean values of medial joint width in unloaded and standardized loaded conditions using a fixation device could be demonstrated. Based on the results of this study, medial knee joint width in US is gender- and age-related in healthy knees. These present data may be useful for evaluating patients with acute or chronic pathologies to the medial side of the knee. Level of evidence III.


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