Effect of Administration of Gamma-Linolenic Acid on the Fatty Acid Composition of Serum Phospholipids and Cholesteryl Esters in Patients with Cystic Fibrosis

Abstract The fatty acid composition of seed oils of eight Ranunculaceae was determinated in order to characterize new sources of gamma-linolenic acid. Fatty acids were identified as fatty acid methyl esters (FAME) by capillary gas-liquid chromatography (GC) and capillary GC-Fourier transform infrared spectroscopy (FTIR). For trienic FAME the use of a cyanopropyl-polysiloxane stationary phase (CP-Sil 88) allowed the separation with high resolution of methyl ester of columbinic acid (trans-5,cis-9,cis-12 18:3) and gamma-linolenic acid (cis-6,cis-9,cis-12 18:3). The results confirmed the presence of columbinic acid in Thalictrum seed oils, and that of gamma-linolenic acid in Anemone and related species seed oils. The taxonomic subdivision of Ranunculaceae into sub-families and tribes, which resulted from morphological considerations, did not account for the above results.

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Effects of Feeding a Supplement of _-Linolenic Acid Containing Oils with Fish Oil on the Fatty Acid Composition of Serum Phospholipids in Healthy Volunteers

Gamma -Linolenic Acid ◽

10.1201/9781439831939.ch13 ◽

1996 ◽

Author(s):

Armand Christophe

Keyword(s):

Fatty Acid Composition ◽

Fatty Acid ◽

Fish Oil ◽

Healthy Volunteers ◽

Linolenic Acid ◽

Acid Composition ◽

Serum Phospholipids

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Effects of the flavonol quercetin and α-linolenic acid on n-3 PUFA status in metabolically healthy men and women: a randomised, double-blinded, placebo-controlled, crossover trial

British Journal Of Nutrition ◽

10.1017/s0007114517000241 ◽

2017 ◽

Vol 117 (5) ◽

pp. 698-711 ◽

Cited By ~ 13

Author(s):

Constanze Burak ◽

Siegfried Wolffram ◽

Berndt Zur ◽

Peter Langguth ◽

Rolf Fimmers ◽

...

Keyword(s):

Fatty Acid Composition ◽

Fatty Acid ◽

Linolenic Acid ◽

Acid Composition ◽

Crossover Trial ◽

Men And Women ◽

Healthy Men ◽

Metabolically Healthy ◽

Double Blinded ◽

Serum Phospholipids

AbstractIncreased dietary intake and tissue status of the long-chain n-3 PUFA, EPA and DHA, is associated with cardiovascular benefits. Epidemiological and animal studies suggest that concomitant nutritive intake of flavonoids may increase the conversion of α-linolenic acid (ALA) to longer-chain n-3 fatty acids EPA and DHA. We investigated the effects of increased ALA intake on fatty acid composition of serum phospholipids and erythrocytes in metabolically healthy men and women and whether fatty acid profiles and ALA conversion were affected by regular quercetin intake or sex. Subjects (n 74) were randomised to receive at least 3·3 g/d ALA with either 190 mg/d quercetin (ALA+quercetin) or placebo (ALA+placebo) in a double-blinded, placebo-controlled, crossover trial with 8-week intervention periods separated by an 8-week washout period. A total of seven subjects dropped out for personal reasons. Data from the remaining sixty-seven subjects (thirty-four males and thirty-three females) were included in the analysis. Both interventions significantly increased serum phospholipid ALA (ALA+placebo: +69·3 %; ALA+quercetin: +55·8 %) and EPA (ALA+placebo: +37·3 %; ALA+quercetin: +25·5 %). ALA + quercetin slightly decreased DHA concentration by 9·3 %. Erythrocyte ALA and EPA significantly increased with both interventions, whereas DHA decreased. Fatty acid composition did not differ between sexes. We found no effect of quercetin. Intake of 3·6 g/d ALA over an 8-week period resulted in increased ALA and EPA, but not DHA, in serum phospholipids and erythrocytes. Neither quercetin supplementation nor sex affected the increment of ALA and relative proportions of n-3 PUFA in serum phospholipids and erythrocytes.

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