Influence of Lansoprazole on Intragastric 24-Hour pH, Meal-Stimulated Gastric Acid Secretion, and Concentrations of Gastrointestinal Hormones and Enzymes in Serum and Gastric Juice in Healthy Volunteers

Digestion ◽  
1995 ◽  
Vol 56 (2) ◽  
pp. 137-144 ◽  
Author(s):  
G. Brunner ◽  
M. Hell ◽  
K.J. Hengels ◽  
U. Hennig ◽  
W. Fuchs
Keyword(s):  
Acid Secretion ◽  
Healthy Volunteers ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Gastric Juice ◽  
Gastrointestinal Hormones

Peptide histidine valine-42 stimulates gastric acid secretion in man

1989 ◽  
Vol 9 (3) ◽  
pp. 369-374 ◽  
Author(s):  
G. C. Nikou ◽  
Y. Yiangou ◽  
B. J. Chrysanthou ◽  
J. Domin ◽  
S. R. Bloom
Keyword(s):  
Gastric Secretion ◽  
Acid Secretion ◽  
Healthy Volunteers ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Local Control ◽  
Significant Stimulation ◽  
New Finding ◽  
Stimulation Of

The effect of peptide histidine valine-42 (PHV-42) on gastric acid secretion was studied in man. PHV-42 was infused into 5 healthy volunteers at a dose of 10 pmol/kg/min. This dose caused a significant stimulation of basal gastric acid and potassium output. there were no significant changes in circulating gastrin throughout the infusion. In 2 subjects with a background of submaximal pentagastrin stimulation, PHV-42 infusion at the same dose did not alter acid secretion in either subject. The previous observation that PHV-42 is found particularly in the stomach and the new finding that it stimulates basal gastric secretion suggest the possibility that PHV-42 could have a role in local control of acid secretion.

Tubeless tests for gastric acid

1964 ◽  
Vol 2 (23) ◽  
pp. 91-92
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Gastric Juice ◽  
False Negative ◽  
Pernicious Anaemia ◽  
Rheumatoid Disease ◽  
Negative Results ◽  
False Negative Results ◽  
Hypochromic Anaemia

Absence of gastric acid secretion (anacidity, pH of gastric juice 7 or over) or abnormally low gastric acid secretion (achlorhydria, pH of gastric juice between 3. 6 and 7, depending on the definition) is evidence of the atrophy of gastric mucosa which is always present in adults with pernicious anaemia, and often accompanies chronic hypochromic anaemia, rheumatoid disease, myxoedema, diabetes mellitus, aplastic anaemia, steatorrhoea, and gastric carcinoma; it also occurs in relatives of patients with pernicious anaemia. The only indication for the use of tubeless tests is to demonstrate gastric acid secretion, thus excluding the diagnosis of pernicious anaemia in an anaemic adult. The tests can reliably show that acid is present, but they cannot show conclusively that acid is absent: false negative results are not uncommon. 1–3 For this reason some consultants doubt whether these tests are worth using.

Teaching the role of secretin in the regulation of gastric acid secretion using a classic paper by Johnson and Grossman

2009 ◽  
Vol 33 (3) ◽  
pp. 165-168 ◽  
Author(s):  
Kristen L. W. Walton
Keyword(s):  
Gastrointestinal Tract ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Feedback Loop ◽  
Gastrointestinal Hormones ◽  
The Subject ◽  
Classic Paper ◽  
Insight Into

The regulation of gastric acid secretion has been the subject of investigation for over a century. Inhibition of gastrin-induced acid secretion by the intestine-derived hormone secretin provides a classic physiological example of negative feedback in the gastrointestinal tract. A classic paper by Leonard R. Johnson and Morton I. Grossman clearly shows the ability of secretin to negatively regulate gastric acid secretion, providing students with an example of this feedback loop. In addition, this article demonstrates the step forward in gastrointestinal endocrinology that occurred when pure preparations of secretin and other gastrointestinal hormones first became available. The comparison of the effects of exogenous, purified secretin to the physiological stimulus of acid in the duodenum is an important example of how newly available reagents allow scientists such as Johnson and Grossman to clarify the mechanisms behind previously established processes. One or more figures from this classic paper can be used to give students insight into the role of secretin in the regulation of the function of the gastrointestinal tract and will also give students a clear example of how the careful experimentation and clear interest in gastrointestinal physiology led Johnson and Grossman to advance the field.

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