Acute intragastric administration of capsaicin stimulates release of SP and CGRP and enhances gastric acid secretion in healthy volunteers

1998 ◽  
Vol 114 ◽  
pp. A1141
Author(s):  
K. Erlandsson ◽  
X Wu ◽  
R. Ekman ◽  
L. Ohbe ◽  
A. Hamlet
1989 ◽  
Vol 9 (3) ◽  
pp. 369-374 ◽  
Author(s):  
G. C. Nikou ◽  
Y. Yiangou ◽  
B. J. Chrysanthou ◽  
J. Domin ◽  
S. R. Bloom

The effect of peptide histidine valine-42 (PHV-42) on gastric acid secretion was studied in man. PHV-42 was infused into 5 healthy volunteers at a dose of 10 pmol/kg/min. This dose caused a significant stimulation of basal gastric acid and potassium output. there were no significant changes in circulating gastrin throughout the infusion. In 2 subjects with a background of submaximal pentagastrin stimulation, PHV-42 infusion at the same dose did not alter acid secretion in either subject. The previous observation that PHV-42 is found particularly in the stomach and the new finding that it stimulates basal gastric secretion suggest the possibility that PHV-42 could have a role in local control of acid secretion.


2016 ◽  
Vol 239 (3) ◽  
pp. 237-241 ◽  
Author(s):  
Katsunori Iijima ◽  
Tomoyuki Koike ◽  
Yasuhiko Abe ◽  
Shuichi Ohara ◽  
Tooru Shimosegawa

2000 ◽  
Vol 118 (4) ◽  
pp. A1280
Author(s):  
Peter Muller ◽  
Mehmet A. Goksu ◽  
Winfried Am Fuchs ◽  
Frank Schluter ◽  
Bernd Simon ◽  
...  

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