Potential Effect of Olanzapine on Total Antioxidant Status and Lipid Peroxidation in Schizophrenic Patients

We investigated the antioxidant action of a solid preparation of Xingnaojing (XNJ) and ascorbic acid (AA) in stroke-prone spontaneously hypertensive rats (SHRSP). The total antioxidant states in the plasma, systolic blood pressure, and heart rate were measured every 2 weeks, and lipid peroxidation, expressed as thiobarbituric acid-reactive substances in plasma, was measured in the 6th week. The results showed that AA and XNJ significantly increased the total antioxidant status in plasma and reduced malondialdehyde in the plasma. These data suggest that during 6-week administration, XNJ has antioxidant action on SHRSP, which may relate to its generalized inhibition of lipid peroxidation and promotion of the total antioxidant state. These results demonstrated that orally treated XNJ has an antioxidant effect on SHRSP plasma.

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Protective Effect of Pulp Oil Extracted fromCanarium odontophyllumMiq. Fruit on Blood Lipids, Lipid Peroxidation, and Antioxidant Status in Healthy Rabbits

Oxidative Medicine and Cellular Longevity ◽

10.1155/2012/840973 ◽

2012 ◽

Vol 2012 ◽

pp. 1-9 ◽

Cited By ~ 12

Author(s):

Faridah Hanim Shakirin ◽

Azrina Azlan ◽

Amin Ismail ◽

Zulkhairi Amom ◽

Lau Cheng Yuon

Keyword(s):

Lipid Peroxidation ◽

Lipid Profile ◽

Antioxidant Status ◽

Corn Oil ◽

Total Antioxidant Status ◽

Blood Lipid ◽

Normal Diet ◽

Kernel Oil ◽

Total Antioxidant ◽

Canarium Odontophyllum

The aim of this paper was to compare the effects of pulp and kernel oils ofCanarium odontophyllumMiq. (CO) on lipid profile, lipid peroxidation, and oxidative stress of healthy rabbits. The oils are rich in SFAs and MUFAs (mainly palmitic and oleic acids). The pulp oil is rich in polyphenols. Male New Zealand white (NZW) rabbits were fed for 4 weeks on a normal diet containing pulp (NP) or kernel oil (NK) of CO while corn oil was used as control (NC). Total cholesterol (TC), HDL-C, LDL-c and triglycerides (TG) levels were measured in this paper. Antioxidant enzymes (superoxide dismutase and glutathione peroxidise), thiobarbiturate reactive substances (TBARSs), and plasma total antioxidant status (TAS) were also evaluated. Supplementation of CO pulp oil resulted in favorable changes in blood lipid and lipid peroxidation (increased HDL-C, reduced LDL-C, TG, TBARS levels) with enhancement of SOD, GPx, and plasma TAS levels. Meanwhile, supplementation of kernel oil caused lowering of plasma TC and LDL-C as well as enhancement of SOD and TAS levels. These changes showed that oils of CO could be beneficial in improving lipid profile and antioxidant status as when using part of normal diet. The oils can be used as alternative to present vegetable oil.

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IN VIVO ANALYSIS OF LIPID PEROXIDATION AND TOTAL ANTIOXIDANT STATUS IN SUBJECTS TREATED WITH STAINLESS STEEL ORTHODONTIC APPLIANCES

Journal of Health and Allied Sciences NU ◽

10.1055/s-0040-1703684 ◽

2013 ◽

Vol 03 (03) ◽

pp. 083-086

Author(s):

Dilip Daniel Quadras ◽

U.S. Krishna Nayak ◽

Suchetha Kumari N. ◽

Prashant Pujari ◽

Vijay R. ◽

...

Keyword(s):

Lipid Peroxidation ◽

Stainless Steel ◽

Antioxidant Status ◽

Total Antioxidant Status ◽

Immunological Tolerance ◽

Orthodontic Appliances ◽

Time Interval ◽

Total Antioxidant ◽

Fixed Appliances

Abstract Introduction: Nickel is a strong immunologic sensitizer, although nickel sensitivity has been reported to be lower in subjects who have received orthodontic treatment; perhaps they develop immunological tolerance over the long period of treatment. Hence the present aim of the work was to determine the levels of lipid peroxidation and total antioxidant status in Serum and Saliva in subjects treated with stainless steel Orthodontic appliances. Methods and Materials: The study group included 25 participants and Samples were taken in different time intervals: Time interval 1- Collection of samples before the appliances fixed, Time interval 2- Collection of sample after one week of fixed appliances, Time interval 3- Collection of sample after three months of fixed appliances each from the Orthodontic Department of A. B.Shetty Memorial institute of dental science.Lipid peroxidation (Malondialdehyde) level is estimated using Thiobarbituric acid (TBA) method. Total antioxidant level was estimated using Phosphomolybdenum method. Conclusion: Total antioxidant and Malondialdehyde levels are increased in case of Females compared to Males in serum whereas in case of Saliva Total antioxidant level is increased in Time interval 2 and 3 in Males compared to Females.

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