Effect of Hydrocortisone, Methylprednisolone Aceponate and Momethasone Furoate on Collagen Synthesis in Human Skin in vivo

1997 ◽  
Vol 10 (5-6) ◽  
pp. 261-264 ◽  
Author(s):  
K.-M. Haapasaari ◽  
J. Risteli ◽  
J. Karvonen ◽  
A. Oikarinen
Keyword(s):  
Human Skin ◽  
Collagen Synthesis ◽  
Methylprednisolone Aceponate

Anti-miR-200b promotes wound healing by regulating fibroblast functions in a novel mouse model

2019 ◽  
Vol 51 (10) ◽  
pp. 1049-1055
Author(s):  
Renpeng Zhou ◽  
Chen Wang ◽  
Yimin Liang ◽  
Xiangqi Li ◽  
Qingfeng Li
Keyword(s):  
Cell Proliferation ◽  
Wound Healing ◽  
Human Skin ◽  
Collagen Synthesis ◽  
Loss Of Function ◽  
Delayed Wound Healing ◽  
Anatomical Features ◽  
Gain Loss ◽  
Critical Aspects

Abstract MicroRNA-200b (miR-200b) down-regulation has been found in wound-healing tissues. Fibroblasts are the predominant cells that orchestrate the production of collagen in wound healing. However, it is still unclear whether miR-200b can affect the wound healing by regulating the fibroblasts’ function. The current rodent wound-healing models are not ideal due to their marked difference in structure compared with the human skin. In this study, we demonstrated that the murine plantar skin had similar anatomical features to the human skin. Using this model, the gain/loss-of-function studies showed that miR-200b caused a significantly delayed wound healing in vivo. Furthermore, using cell proliferation, migration and collagen synthesis assays, we found that miR-200b attenuated cell proliferation, migration and collagen synthesis of fibroblasts, which are critical aspects of wound healing. miR-200b also decreased the expression of Zeb1. Collectively, we established a new murine plantar skin model for the investigation of wound healing, and based on it we found that miR-200b affected the wound healing by regulating the biological function of fibroblasts, which provided a new insight for wound healing.

scholarly journals Demonstration of increased collagen synthesis in irradiated human skin in vivo

1998 ◽  
Vol 77 (12) ◽  
pp. 2331-2335 ◽  
Author(s):  
P Autio ◽  
T Saarto ◽  
M Tenhunen ◽  
I Elomaa ◽  
J Risteli ◽  
...  
Keyword(s):  
Human Skin ◽  
Collagen Synthesis
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