scholarly journals Prevalence of Family History of Breast, Colorectal, Prostate, and Lung Cancer in a Population-Based Study

2010 ◽  
Vol 13 (7-8) ◽  
pp. 495-503 ◽  
Author(s):  
P.L. Mai ◽  
L. Wideroff ◽  
M.H. Greene ◽  
B.I. Graubard
Keyword(s):  
Lung Cancer ◽  
Family History ◽  
Population Based ◽  
Population Based Study ◽  
History Of

Association between Family History of Benign Prostatic Hyperplasia and Urinary Symptoms: Results of a Population-based Study

1995 ◽  
Vol 142 (9) ◽  
pp. 965-973 ◽  
Author(s):  
Rosebud O. Roberts ◽  
Thomas Rhodes ◽  
Laurel A. Panser ◽  
Cynthia J. Girman ◽  
Christopher G. Chute ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Family History ◽  
Population Based ◽  
Prostatic Hyperplasia ◽  
Urinary Symptoms ◽  
Population Based Study ◽  
History Of

scholarly journals Family History of Breast Cancer in Relation to Tumor Characteristics and Mortality in a Population-Based Study of Young Women with Invasive Breast Cancer

2011 ◽  
Vol 20 (12) ◽  
pp. 2560-2571 ◽  
Author(s):  
Kathleen E. Malone ◽  
Janet R. Daling ◽  
David R. Doody ◽  
Cecilia O'Brien ◽  
Alexa Resler ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Young Women ◽  
Invasive Breast Cancer ◽  
Population Based ◽  
Tumor Characteristics ◽  
Population Based Study ◽  
History Of

Family History Of Hematologic Malignancies and Disorders In a Population Based Study Of Myelodysplastic Syndromes (MDS)

Blood ◽  
2013 ◽  
Vol 122 (21) ◽  
pp. 1541-1541
Author(s):  
Angela R. Smith ◽  
Erica D. Warlick ◽  
Rachel K. Fonstad ◽  
Michelle A. Roesler ◽  
Jenny N. Poynter ◽  
...  
Keyword(s):  
Family History ◽  
Conflicts Of Interest ◽  
Positive Family History ◽  
Hematologic Malignancies ◽  
Population Based ◽  
Newly Diagnosed ◽  
Population Based Study ◽  
Hematopoietic Stem ◽  
Increased Risk ◽  
History Of

Abstract Background MDS is a clonal hematopoietic stem cell disorder characterized by dysplastic changes in the bone marrow, ineffective hematopoiesis and an increased risk for developing acute myeloid leukemia (AML). The majority of MDS cases are sporadic, but rare familial cases have been described and are often ascertained through clinic-based referrals. To our knowledge, no population based study of MDS has examined the frequency of family history of hematologic malignancies and disorders in patients, nor associations with disease characteristics and outcomes. Methods Newly diagnosed MDS cases are being identified by rapid case ascertainment by the Minnesota Cancer Surveillance System (MCSS), a population-based cancer registry in Minnesota. Eligibility criteria include all newly diagnosed cases of MDS during the period April 1, 2010-October 31, 2014, between 20-85 years, Minnesota resident, and ability to understand English or Spanish. Proxy interviews are not being conducted. Medical records and biologic samples are obtained and questionnaires are filled out by participants. Centralized pathology and cytogenetics review confirm diagnosis and classify by subtype and risk score including the Revised International Prognostic Scoring System (IPSS-R). Since 2010, information on family history has been obtained through questionnaire responses and/or medical record review on 353 MDS patients. Cases were considered to have a positive family history if they reported a first degree relative with MDS, leukemia, lymphoma or other hematologic condition (multiple myeloma [n=4], Waldenstrom’s macroglobulinemia [n=1] and idiopathic thrombocytopenic purpura [n=1]). Treatment related MDS cases were excluded leaving 330 MDS patients for analysis. Unconditional logistic regression was used to calculate crude odds ratios (ORs) and 95% confidence intervals (CI) overall and by sex. Results A total of 61/330 (18.5%) cases reported a family history of a hematologic condition. The mean age at diagnosis was 71.3 years in those with a family history compared to 72.2 years in those without a family history (p=0.53). There was no difference in the sex distribution between the two groups. Though not statistically significant, the odds of having abnormal cytogenetics or an IPSS-R of High/Very High was lower for those having a positive family history (OR 0.57 [CI 0.25-1.33, p=0.19 and 0.67 [CI 0.24-1.84, p=0.29], respectively). The odds of survival at one year after diagnosis was significantly higher in those with a family history (OR 2.79 [CI 1.04-7.51, p=0.04]) compared to those without (Table). Further stratification by sex revealed that this association was strongest for males (OR=4.23, [CI 0.94-19.0, p=0.06] compared to females (OR=1.84 [CI=0.47-7.19, p=0.38]). Discussion In this population based study of adults with MDS, the prevalence of MDS cases having a positive family history was higher than previous reports. Additionally, cases reporting a family history of hematologic malignancies and disorders appear to experience lower risk disease and have significantly improved overall survival, especially males. It is possible that patients with a family history of hematologic conditions are diagnosed earlier in the course of their disease secondary to increased awareness about blood disorders and/or more active screening within the family. Our analysis is limited by relatively small numbers, but enrollment is ongoing so subsequent analyses with larger numbers of subjects may be more revealing. Additionally, a prospective study to examine these families further, including detailed medical histories and collection of biospecimens (saliva, blood, skin) for genetic analyses is underway in order to identify potential mechanisms and mutations involved in the development of MDS and progression to AML. Disclosures: No relevant conflicts of interest to declare.

scholarly journals The Impact of Family History of Allergy on Risk of Food Allergy: A Population-Based Study of Infants

2013 ◽  
Vol 10 (11) ◽  
pp. 5364-5377 ◽  
Author(s):  
Jennifer Koplin ◽  
Katrina Allen ◽  
Lyle Gurrin ◽  
Rachel Peters ◽  
Adrian Lowe ◽  
...  
Keyword(s):  
Food Allergy ◽  
Family History ◽  
Population Based ◽  
Population Based Study ◽  
History Of ◽  
The Impact

Association of Parity and Ovarian Cancer Risk by Family History of Breast or Ovarian Cancer in a Population-Based Study of Postmenopausal Women

Epidemiology ◽  
2002 ◽  
Vol 13 (1) ◽  
pp. 66-71 ◽  
Author(s):  
Celine M. Vachon ◽  
Pamela J. Mink ◽  
Carol A. Janney ◽  
Thomas A. Sellers ◽  
James R. Cerhan ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Family History ◽  
Cancer Risk ◽  
Postmenopausal Women ◽  
Population Based ◽  
Ovarian Cancer Risk ◽  
Population Based Study ◽  
History Of

scholarly journals Beliefs about cancer causation and prevention as a function of personal and family history of cancer: a national, population-based study

2008 ◽  
Vol 17 (10) ◽  
pp. 967-974 ◽  
Author(s):  
Emily L. B. Lykins ◽  
Lili O. Graue ◽  
Emily H. Brechting ◽  
Abbey R. Roach ◽  
Celestine G. Gochett ◽  
...  
Keyword(s):  
Family History ◽  
Population Based ◽  
Population Based Study ◽  
Family History Of Cancer ◽  
National Population ◽  
History Of ◽  
History Of Cancer

scholarly journals Raising concerns about family history of breast cancer in primary care consultations: prospective, population based study

BMJ ◽  
2001 ◽  
Vol 322 (7277) ◽  
pp. 27-28 ◽  
Author(s):  
Women's Concerns Study Group
Keyword(s):  
Breast Cancer ◽  
Primary Care ◽  
Family History ◽  
Population Based ◽  
Population Based Study ◽  
History Of

scholarly journals MA03.10 Population-Based Relative Risks for Lung Cancer Based on Complete Family History of Lung Cancer

2018 ◽  
Vol 13 (10) ◽  
pp. S365
Author(s):  
L. Cannon-Albright ◽  
W. Akerley ◽  
S. Carr
Keyword(s):  
Lung Cancer ◽  
Family History ◽  
Population Based ◽  
Complete Family ◽  
Relative Risks ◽  
History Of
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