Dendritic Cells Orchestrate Innate Immunity against Bacterial Kidney Infection

2013 ◽  
pp. 112-119
Author(s):  
André P. Tittel ◽  
Christoph Heuser ◽  
Natalio Garbi ◽  
Christian Kurts
Keyword(s):  
Innate Immunity ◽  
Dendritic Cells

The role of monocytes in thrombotic disorders

2009 ◽  
Vol 102 (11) ◽  
pp. 916-924 ◽  
Author(s):  
Gregory Lip ◽  
Eduard Shantsila
Keyword(s):  
Innate Immunity ◽  
Dendritic Cells ◽  
Tissue Factor ◽  
Physiological Role ◽  
Coagulation Cascade ◽  
Pathophysiological Role ◽  
Platelet Aggregates

SummaryAlthough, the main physiological role of monocytes is attributed to innate immunity (that is, phagocytosis) and the development of tissue macrophages and dendritic cells, the pathophysiological role of these goes far behind these (simplistic) limits. Indeed, monocytes constitute a major source of blood tissue factor, a key element of the extrinsic coagulation cascade. Monocytes actively bind to platelets, thus forming very prothrombotic monocyte-platelet aggregates. Additionally, these cells link inflammation and the procoagulant state observed in various prothrombotic conditions. However, monocytes are also crucial for successful thrombus recanalisation. In this article, we review the available data on potential mechanisms that link monocytes with thrombosis-related processes.

CD209 (DC-SIGN) – role in the work of the innate immunity and pathogen penetration

2020 ◽  
Vol 1 (9) ◽  
pp. 64-71
Author(s):  
E. A. Klimov ◽  
◽  
E. K. Novitskaya ◽  
S. N. Koval’chuk ◽  
◽  
...  
Keyword(s):  
Immune Response ◽  
Innate Immunity ◽  
Dendritic Cells ◽  
Inflammatory Response ◽  
Signaling Pathway ◽  
Adhesion Molecule ◽  
Immune Evasion ◽  
Intercellular Adhesion Molecule ◽  
Lectin Receptor

Intercellular adhesion molecule CD209 (DC-SIGN) is a membrane C-type lectin receptor expressed on the surface of dendritic cells and macrophages. CD209 plays an important role in innate immunity. Many studies have shown the possibility of interaction of the CD209 molecule with a number of dangerous pathogens of humans and animals. This review summarizes information on the structure of the CD209 gene and its product, describes the role of the CD209 protein in the immune response, in the migration of dendritic cells from the blood to the tissue, and their interaction with neutrophils. The currently known signaling pathway of activation through the CD209 inflammatory response is presented. The role of CD209 as an endocytic antigen receptor and the participation of the protein in immune evasion of pathogens are discussed. The mechanisms known to date for the development of infections caused by pathogens of various nature in animals are described.

scholarly journals Amplifying IFN-γ Signaling in Dendritic Cells by CD11c-Specific Loss of SOCS1 Increases Innate Immunity to Infection while Decreasing Adaptive Immunity

2017 ◽  
Vol 200 (1) ◽  
pp. 177-185 ◽  
Author(s):  
Alejandro F. Alice ◽  
Gwen Kramer ◽  
Shelly Bambina ◽  
Jason R. Baird ◽  
Keith S. Bahjat ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Dendritic Cells ◽  
Adaptive Immunity ◽  
Specific Loss ◽  
Ifn Γ

Plasmacytoid dendritic cells—virus experts of innate immunity

2005 ◽  
Vol 17 (4) ◽  
pp. 253-261 ◽  
Author(s):  
Winfried Barchet ◽  
Marina Cella ◽  
Marco Colonna
Keyword(s):  
Innate Immunity ◽  
Dendritic Cells ◽  
Plasmacytoid Dendritic Cells

scholarly journals Short-Range Exosomal Transfer of Viral RNA from Infected Cells to Plasmacytoid Dendritic Cells Triggers Innate Immunity

2012 ◽  
Vol 12 (4) ◽  
pp. 558-570 ◽  
Author(s):  
Marlène Dreux ◽  
Urtzi Garaigorta ◽  
Bryan Boyd ◽  
Elodie Décembre ◽  
Josan Chung ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Dendritic Cells ◽  
Short Range ◽  
Plasmacytoid Dendritic Cells ◽  
Viral Rna ◽  
Infected Cells

scholarly journals Metabolic reprogramming in macrophages and dendritic cells in innate immunity

Cell Research ◽  
2015 ◽  
Vol 25 (7) ◽  
pp. 771-784 ◽  
Author(s):  
Beth Kelly ◽  
Luke AJ O'Neill
Keyword(s):  
Innate Immunity ◽  
Dendritic Cells ◽  
Metabolic Reprogramming

scholarly journals Innate Immunity toLeishmaniaInfection: Within Phagocytes

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Marcela Freitas Lopes ◽  
Ana Caroline Costa-da-Silva ◽  
George Alexandre DosReis
Keyword(s):  
Innate Immunity ◽  
Dendritic Cells ◽  
Tissue Repair ◽  
Leishmania Major ◽  
Host Cells ◽  
Infection Site ◽  
Experimental Findings ◽  
Inflammatory Macrophages

Infection byLeishmaniatakes place in the context of inflammation and tissue repair. Besides tissue resident macrophages, inflammatory macrophages and neutrophils are recruited to the infection site and serve both as host cells and as effectors against infection. Recent studies suggest additional important roles for monocytes and dendritic cells. This paper addresses recent experimental findings regarding the regulation ofLeishmania majorinfection by these major phagocyte populations. In addition, the role of IL-4 on dendritic cells and monocytes is discussed.

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