Specificity of Cytotoxic T Lymphocytes Stimulated with Influenza Virus

2015 ◽  
pp. 10-43 ◽  
Author(s):  
Alain R. M. Townsend ◽  
Andrew J. McMichael
Keyword(s):  
Influenza Virus ◽  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes

scholarly journals HLA restriction of human cytotoxic T lymphocytes specific for influenza virus. Poor recognition of virus associated with HLA A2.

1978 ◽  
Vol 148 (6) ◽  
pp. 1458-1467 ◽  
Author(s):  
A McMichael
Keyword(s):  
Influenza Virus ◽  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Influenza A ◽  
Human Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
The Other ◽  
Target Cells ◽  
Surface Molecules ◽  
Human Peripheral Blood Lymphocytes

Cytotoxic T lymphocytes (CTL), specific for influenza A/X31 virus, were generated from human peripheral blood lymphocytes. These CTL lysed target cells that were infected with the same virus and that shared HLA A or B locus antigens. Minimal lysis was observed when HLA-D antigens were shared. Not all HLA A and B antigens were equally effective. Efficient lysis of target cells was seen when HLA A1, A3, B7, B8, B27 and BW21 were shared with the CTL, but when HLA A2 was the only shared antigen lysis was usually minimal. This deficiency in CTL function associated with HLA A2 was not absolute. It is suggested that the function of this antigen might be influenced by other surface molecules on the cell and in particular the other HLA products.

Generation of Ag-specific cytotoxic T lymphocytes by DC transfected with in vitro transcribed influenza virus matrix protein (M1) mRNA

Cytotherapy ◽  
2003 ◽  
Vol 5 (2) ◽  
pp. 161-168 ◽  
Author(s):  
Y. Osman ◽  
M. Narita ◽  
F. Ayres ◽  
M. Takahashi ◽  
L. Alldawi ◽  
...  
Keyword(s):  
Influenza Virus ◽  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Matrix Protein ◽  
Matrix Protein M1

Soluble HLA-A2.1 restricted peptides that are recognized by influenza virus specific cytotoxic T lymphocytes

1991 ◽  
Vol 139 (1) ◽  
pp. 41-47 ◽  
Author(s):  
Maria A. Bednarek ◽  
Sara A. Engl ◽  
Maureen C. Gammon ◽  
Jonathan A. Lindquist ◽  
Gene Porter ◽  
...  
Keyword(s):  
Influenza Virus ◽  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Soluble Hla ◽  
Hla A2.1

Recognition of the PB1, neuraminidase, and matrix proteins of influenza virus A/NT/60/68 by cytotoxic T lymphocytes

Virology ◽  
1989 ◽  
Vol 170 (2) ◽  
pp. 477-485 ◽  
Author(s):  
Philip A. Reay ◽  
Ian M. Jones ◽  
Frances M. Gotch ◽  
Andrew J. Mcmichael ◽  
George G. Brownlee
Keyword(s):  
Influenza Virus ◽  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Matrix Proteins ◽  
Influenza Virus A
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