Effect of Ticlopidine on Biocompatibility of Dialysis Membranes

Macromolecular substances that cause pitting and other modifications of growing ice crystals were found to be associated with cyanobacterial mats, eukaryotic algae and mosses from Ross Island and the McMurdo Dry Valleys, Antarctica. Ice-pitting activities were largely retained by dialysis membranes with molecular weight cut-offs of up to 300 kDa. Unlike most aqueous solutes, the ice-active molecules were not excluded from the ice phase during freezing. The ice-pitting activities of each of the samples tested was destroyed by exposure to temperatures between 45 and 65°C, suggesting that they have a protein component. Ice-active substances were not found in cyanobacteria or mosses from temperate climates, but ice-activity was found to be associated with mosses from cold habitats in North America. Although the function of the ice-active substances is not known, their apparent confinement to cold environments suggests that they have a cryoprotective role.

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Neutrophil Oxygen Radical Production by Dialysis Membranes

Nephrology Dialysis Transplantation ◽

10.1093/oxfordjournals.ndt.a091724 ◽

1988 ◽

Vol 3 (5) ◽

pp. 661-665 ◽

Cited By ~ 34

Author(s):

T. Kuwahara ◽

M. Markert ◽

J.P. Wauters

Keyword(s):

Oxygen Radical ◽

Radical Production ◽

Dialysis Membranes ◽

Oxygen Radical Production

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Relationship between serum β2-microglobulin bone histology, and dialysis membranes in uraemic patients

Nephrology Dialysis Transplantation ◽

10.1093/ndt/10.9.1701 ◽

1995 ◽

Keyword(s):

Bone Histology ◽

Dialysis Membranes

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An Immunohistochemical Technique for the Study of Plasma Proteins Adsorbed on Dialysis Membranes

Current Therapy in Nephrology ◽

10.1007/978-1-4613-0865-2_81 ◽

1989 ◽

pp. 306-308

Author(s):

V. Panichi ◽

A. M. Bianchi ◽

L. Casarosa ◽

M. Parrini ◽

G. Grazi ◽

...

Keyword(s):

Plasma Proteins ◽

Immunohistochemical Technique ◽

Dialysis Membranes

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Plasma B2-Microglobullin (B2M) Changes Induced by Different Dialysis Membranes

Current Therapy in Nephrology ◽

10.1007/978-1-4613-0865-2_67 ◽

1989 ◽

pp. 245-247

Author(s):

G. Sakellariou ◽

E. Kokolina ◽

P. Margari ◽

B. Pastourmatzi ◽

M. Papadimi-Triou

Keyword(s):

Dialysis Membranes

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Intradialytic granulocyte reactive oxygen species production: a prospective, crossover trial.

Journal of the American Society of Nephrology ◽

10.1681/asn.v42178 ◽

1993 ◽

Vol 4 (2) ◽

pp. 178-186 ◽

Cited By ~ 2

Author(s):

J Himmelfarb ◽

K A Ault ◽

D Holbrook ◽

D A Leeber ◽

R M Hakim

Keyword(s):

Reactive Oxygen Species ◽

Reactive Oxygen ◽

Fold Increase ◽

Ros Production ◽

Oxygen Species ◽

Susceptibility To Infection ◽

Flow Cytometric ◽

Ros Formation ◽

Dialysis Membranes ◽

Species Production

By the use of flow cytometric techniques, this prospective, randomized crossover study was designed to analyze intradialytic granulocyte reactive oxygen species (ROS) formation in whole blood with complement-activating and noncomplement-activating hollow fiber membranes. Dialysis with a complement-activating membrane resulted in a 6.5-fold increase in granulocyte hydrogen peroxide production 15 min after dialysis initiation and remained significantly elevated (P < 0.01) through the first 30 min with this membrane in comparison to both predialysis values and simultaneous values with a noncomplement-activating membrane. Further studies demonstrated that blood obtained at 15 min with a complement-activating membrane generated significantly less granulocyte ROS production in response to Staphylococcus aureus incubation than blood obtained either predialysis or at the same time in dialysis with a noncomplement-activating membrane. Both complement-activating and noncomplement-activating dialysis membranes caused slightly decreased granulocyte responsiveness to phorbol myristate acetate. It was concluded that hemodialysis with complement-activating membranes results in increased granulocyte ROS production and decreased responsiveness to S. aureus challenge during the dialysis procedure. These results document the potential role of ROS in hemodialysis-associated pathology and susceptibility to infection.

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Tolerance of hemodialysis: a randomized prospective trial of high-flux versus conventional high-efficiency hemodialysis.

Journal of the American Society of Nephrology ◽

10.1681/asn.v42148 ◽

1993 ◽

Vol 4 (2) ◽

pp. 148-154

Author(s):

D M Collins ◽

M B Lambert ◽

J S Tannenbaum ◽

M Oliverio ◽

S J Schwab

Keyword(s):

Crossover Trial ◽

High Efficiency ◽

Prospective Trial ◽

Randomized Crossover Trial ◽

Acute Complications ◽

Associated Symptoms ◽

Randomized Prospective Trial ◽

Single Use ◽

Dialysis Membranes ◽

Flow Dialysis

Hemodialysis is frequently complicated by hypotension and associated symptoms. It has been suggested that these symptoms may be related to the biochemical changes caused by cellulosic dialysis membranes. In this study, a prospective randomized crossover trial was conducted comparing the incidence of hypotension and acute symptoms during dialysis with large-surface-area (1.6 m2) cellulosic (cuprophane [CUP]) and noncellulosic (polyacrylonitrile [PAN], AN69) membranes. Dialyzers were used for a single use only. There was no difference in predialysis BUN, predialysis blood pressure, intradialytic weight gain, blood flow, dialysis efficiency (urea reduction), dialysis duration, hematocrit, or erythropoietin dose between the two study phases. When these clinical characteristics were matched, there was no difference in the number of episodes of hypotension (CUP, 19 +/- 3; PAN, 22 +/- 3; P = not significant [NS]). The incidence of symptomatic hypotension, as reflected by the number of episodes of hypotension requiring more than 100 mL of saline for correction, was also not different between study phases (CUP, 10 +/- 1; AN69, 11 +/- 2; P = NS). The incidence of intradialytic symptoms, including emesis, cramping, headache, angina, pruritus, and bronchospasm, was similar during the two study phases (CUP, 11 +/- 2; AN69, 10 +/- 1; P = NS). It was concluded that noncellulosic membranes do not offer any significant advantage over cellulosic membranes in reducing the acute complications of hemodialysis.

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