Drug-Induced Hypersensitivity Syndrome Followed by Subacute Thyroiditis
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Drug-induced hypersensitivity syndrome (DIHS) is a severe multiorgan system adverse drug reaction with reactivation of human herpesviruses (HHVs) such as HHV-6, HHV-7, cytomegalovirus (CMV) and Epstein-Barr virus. Various complications, including autoimmune diseases, sometimes appear during the course of DIHS. We report a case of salazosulfapyridine-induced DIHS associated with HHV-6 reactivation. Two and a half months after the onset of DIHS, subacute thyroiditis occurred, possibly associated with CMV reactivation. Prednisolone (20 mg/day) was effective for subacute thyroiditis. Long-term follow-up is needed in patients with DIHS because of the possible onset of autoimmune diseases.
2010 ◽
Vol 90
(1)
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pp. 93-94
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2010 ◽
Vol 163
(1)
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pp. 174-182
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1985 ◽
Vol 99
(6)
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pp. 567-572
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2004 ◽
Vol 77
(3)
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pp. 479
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