Effectiveness of the Pattern-Based Approach in the Cytodiagnosis of Salivary Gland Lesions

2016 ◽  
Vol 60 (2) ◽  
pp. 107-117 ◽  
Author(s):  
K. Amita ◽  
S. Vijay Shankar ◽  
M. Sanjay ◽  
B.M. Sarvesh
Keyword(s):  
Salivary Gland ◽  
False Negative ◽  
Needle Aspiration ◽  
Cross Sectional Study ◽  
Cytological Diagnosis ◽  
Aspiration Cytology ◽  
Cross Sectional ◽  
Prior Informed Consent ◽  
Needle Aspiration Cytology ◽  
Sensitivity Specificity

Objective: The aim of this study is to investigate, primarily, the effectiveness of the application of pattern-based analysis in the diagnosis of salivary gland (SG) lesions. Secondarily, an attempt was made to study the cytomorphology of the various lesions in detail and discuss the pitfalls and solutions involved in the challenging conditions at cytology. Materials and Methods: This was a prospective, cross-sectional study. All SG lesions over 2 years were subjected to fine-needle aspiration cytology with patients' prior informed consent. The lesions were classified based on the predominant pattern, and a provisional diagnosis was made. The secondary pattern and other features, such as background, were then taken note of, and a combined cytological diagnosis was rendered. The entire spectrum of lesions was divided into 6 morphological categories. Results: We had a total of 72 SG lesions. The most commonly affected gland was the parotid gland in 79.16% (57/72) of the cases. Surgery was performed in 26 cases (36.11%). A concordant diagnosis was obtained in 22 cases. The sensitivity, specificity and diagnostic accuracy by the pattern-based approach was 75, 100 and 88.46%, respectively. There were no false-positive cases, but 2 false-negative cases were recorded. Conclusion: The precise cytological preoperative diagnosis of SG lesions is important for the management of patients. The pattern-based approach can be used routinely in the cytological diagnosis of SG lesions.

scholarly journals Diagnostic Accuracy of Fine needle Aspiration Cytology of Thyroid Nodules at two tertiary Hospitals in Zambia: a cross-sectional study

2020 ◽  
Vol 4 (2) ◽  
pp. 6-13
Author(s):  
Jackson Chipaila ◽  
◽  
Alex Makupe ◽  
Evans Malyangu ◽  
Daniel Maswahu ◽  
...  
Keyword(s):  
Thyroid Nodules ◽  
Needle Aspiration ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Aspiration Cytology ◽  
Cross Sectional ◽  
Predictive Values ◽  
Tertiary Hospitals ◽  
Needle Aspiration Cytology ◽  
Sensitivity Specificity

Introduction: Thyroid nodules are one of the common surgical presentations in Africa and are of great concern because of their potential to be malignant. Zambia is not excluded from these common surgical conditions. However, there are no pre-operative cellular or intra-operative tissue diagnoses of the thyroid nodules done before thyroidectomy making it difficult to plan for an optimal and definitive management. Fine needle aspiration cytology (FNAC) is known to play a pivotal role in the screening and management of thyroid swellings. This study serves to assess the diagnostic accuracy of FNAC on thyroid nodules in patients at two tertiary hospitals in Zambia in order to establish a basis for introducing its use in the management of thyroid nodules at the institutions. Objectives: To evaluate the accuracy of FNAC, as compared to histopathology, in the diagnosis of thyroid nodules at University Teaching Hospital (UTH) and Ndola Central Hospital (NCH) in Zambia. Methods: This was a prospective cross-sectional study conducted in UTH and NCH surgery department from June 2014 to March 2015. Seventy-three patients, who presented with palpable thyroid nodules and underwent thyroidectomy, were enrolled in the study. The FNAC diagnosis of the patients was compared to the histopathology finding following thyroidectomy. Results: Females made up the majority of the patients (n=67, 91.8%). The ages of the patients ranged from 18 to 78 years. The mean age was 44.3 years and the peak age of incidence was in the fourth decade. All patients were clinically euthyroid at the time of enrolment. The FNAC findings included 23 cases reported as unsatisfactory (31.5%); 29 cases benign (39.7%); 2 cases atypical (2.7%); 6 cases suspicious (8.2%); and 13 cases malignant (17.8%). Histopathology findings were available from all 73 tissue samples of participants, of which 55 (75.3%) and 18 (24.7%) were reported as benign and malignant respectively. Of the 18 malignant cases identified by histology, the most common cancer was follicular carcinoma (n=9, 50%), followed by papillary carcinoma (n=6, 33.3%) and undifferentiated carcinoma (n=3, 16.7%). FNAC, in this study, had sensitivity, specificity, negative and positive predictive values, and accuracy of 83.33%, 89.09%, 94.23 and 71.42%, and 87.67% respectively. Conclusion: In this study, FNAC of thyroid nodules had a high sensitivity, specificity, predictive values and accuracy, and can therefore be recommended to be adopted as a pre-operative tool for screening of thyroid nodules.

Comparison of Mammography and Ultrasonography in the Diagnosis of Breast Lesions with Fine Needle Aspiration Cytology – A Cross Sectional Study in East Godavari District, Andhra Pradesh

2021 ◽  
Vol 8 (39) ◽  
pp. 3429-3434
Author(s):  
Sowmya D. ◽  
Anusha S ◽  
Prasanna Pidaparti L.V.S.S.N. ◽  
Jaya Chandra T. ◽  
Mythri Priyadarshini V.
Keyword(s):  
Diagnostic Accuracy ◽  
Needle Aspiration ◽  
Cross Sectional Study ◽  
Breast Lesions ◽  
Sectional Study ◽  
Aspiration Cytology ◽  
Cross Sectional ◽  
Fine Needle ◽  
Needle Aspiration Cytology ◽  
Sensitivity Specificity

BACKGROUND Breast cancer is the second most common malignancy and most common among women next to lung cancer. A small lump in the breast leads to great physical, emotional, and psychological trauma to the victim and as well as family. In addition to clinical examination, imaging modalities like mammography (MG), ultrasonography (USG), cytological diagnosis by fine needle aspiration cytology (FNAC) and tissue diagnosis were used for the diagnosis. These diagnostic techniques have certain pitfalls in addition to their advantages. A study was conducted to evaluate the breast lesions according to breast imaging reporting and data system using MG and USG, correlation with FNAC. METHODS It was a cross-sectional study, conducted in the Department of Radio-diagnosis, GSL Medical College, Rajahmundry from January 2018 to June 2019, over a period of 18 months. An informed consent was taken from all the participants. The individual with palpable breast lesions detected in clinical examination were included. Physiological swelling, ulcerated and fungal breast growths were not considered. After the detailed clinical history, physical examination, MG and USG were performed, proceeded for FNAC, smears were stained with Leishman and Papanicolaou stain. Statistical analysis was performed by Statistical Package for Social Sciences (SPSS version 20.0). Descriptive data was presented in the form of mean, standard deviation and percentages. Chi-square test was done to assess the association among various categorical data, P < 0.05 was considered statistically significant. RESULTS Total 142 participants were included, maximum number belong to 41 to 50 years, 0.7 % were male. Right side lesion was the predominant. With FNAC, the sensitivity, specificity and the diagnostic accuracy were 86.5 %, 97.8 % and 93.7 %, respectively for benign breast lesions (BBL) diagnosis and 96.7 %, 84.6 %, 92.25 % respectively for malignant breast lesions (MBL) diagnosis. CONCLUSIONS The sensitivity, specificity and diagnostic accuracy was observed to be higher in diagnosis of both BBL and MBL with the combined modalities. KEYWORDS Breast Lesions, Benign, Malignant

scholarly journals A comparative study of fine-needle aspiration cytology and histopathology in salivary gland lesions

1970 ◽  
Vol 1 (2) ◽  
pp. 108-113 ◽  
Author(s):  
S Vaidya ◽  
A Sinha ◽  
S Narayan ◽  
S Adhikari ◽  
KC Sabira
Keyword(s):  
Salivary Gland ◽  
Diagnostic Accuracy ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Neoplastic Lesions ◽  
Needle Aspiration Cytology ◽  
Sensitivity Specificity

Background: A wide variety of benign and malignant tumours originate in the salivary glands and insufficient tumour cells make their diagnosis difficult in some patients. The aim of this study was to evaluate the efficacy of fine-needle aspiration cytology in the diagnosis of salivary gland lesions and to correlate cytological findings with histopathology. Materials and Methods: This was a prospective study done from September 2002 to May 2004. Fine needle aspiration cytology was performed in 58 patients with clinically significant salivary gland masses. Results: Fine needle aspiration cytology categorized 67.24% of the salivary gland lesions as neoplastic and 32.76% as non-neoplastic lesions. Amongst the neoplastic lesions, 76.9% were benign and 23.1% were malignant cases. Histopathological examination revealed that 81.05% of the cases were benign and 18.95% were malignant. Fine needle aspiration cytology had a sensitivity, specificity and diagnostic accuracy of 81.82%, 100% and 96.55%, respectively. The positive predictive value and negative predictive value was 100% and 95.9%, respectively. Conclusion: Fine needle aspiration of the salivary gland is a safe and reliable technique in the primary diagnosis of salivary gland lesions. Although, limitations are encountered while predicting specific lesions on cytology, especially when dealing with cystic and some malignant lesions, this study has shown that fine needle aspiration cytology has a high sensitivity, specificity and diagnostic accuracy in diagnosing salivary gland lesions. Keywords: Salivary glands; Fine needle aspiration cytology; Histopathology DOI: http://dx.doi.org/10.3126/jpn.v1i2.5403 JPN 2011; 1(2): 108-113

Fine needle aspiration cytology of salivary gland lesions reported immediately in a head and neck clinic

1993 ◽  
Vol 107 (11) ◽  
pp. 1025-1028 ◽  
Author(s):  
N. J. Roland ◽  
A. W. Caslin ◽  
P. A. Smith ◽  
L. S. Turnbull ◽  
A. Panarese ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Head And Neck ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
False Negative ◽  
Neck Surgery ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

AbstractThis paper describes the application of fine needle aspiration cytology (FNAC) performed on92 patients with salivary gland lesions in a Head and Neck Surgery Clinic. The aspirates were immediately reported by a cytopathologist and the reports conveyed to the surgeon during the same clinic visit. FNAC results were then compared with histology in those patients who underwent surgery and with the clinical course of the disease at subsequent clinic visits in patients where surgery was not performed. The cytological diagnosis was incorrect in five cases, one of which was a false negative result. There were no false positive results. The sensitivity was 90.9 per cent and the specificity 100 per cent. This rapid report system of fine needle aspiration cytology has been found to be safe, free of complications, and helpful in the planning of treatment.

Adequacy of Fine-Needle Aspiration Cytology for Breast Lesions: The SurePath® Liquid-Based Technique versus Conventional Smears

2015 ◽  
Vol 59 (3) ◽  
pp. 253-257 ◽  
Author(s):  
José Eleutério Jr. ◽  
Alessa Aragão ◽  
Diane Isabelle Magno Cavalcante
Keyword(s):  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Cross Sectional Study ◽  
Breast Lesions ◽  
Cystic Lesions ◽  
Aspiration Cytology ◽  
Cross Sectional ◽  
Fine Needle ◽  
Needle Aspiration Cytology ◽  
Cytology Study

Objective: We aimed to assess the cytological findings from fine-needle aspiration (FNA) of breast lesions with conventional smear (CS) and SurePath® (SP) cytology. Study Design: This was a cross-sectional study of women who underwent FNA from January 2012 to June 2013 for breast lesions with benign ultrasonography impressions in Fortaleza, Brazil. Two groups were formed. The first was composed of 102 samples subjected to CS and the second of 65 samples subjected to SP. The number of smears, the cellularity and the diagnostic hypotheses were compared. Fisher's exact tests with 95% confidence intervals were applied. Results: The women ranged in age from 22 to 75 years. SP cytology indicated greater cellularity than CS for the cystic lesions (p < 0.05). In the CS group, 72.5% of the samples required 3-4 slides, but in the SP group, only 9.2% required a second slide. The cellularity of the cystic samples was significantly greater with the SP method (p < 0.01). Conclusion: In FNA cytology of the breast, SP is a tool that is comparable to CS, but with the added benefits of better cellularity results for cystic lesions and requiring fewer slides for analysis.

Solitary Thyroid Nodules - Validity of Ultrasonography, Fine Needle Aspiration Cytology and Sestamibi in Detecting Thyroid Malignancies - A Cross-Sectional Study in Kerala

2021 ◽  
Vol 8 (31) ◽  
pp. 2885-2889
Author(s):  
Shilpa Suresh ◽  
Riju R. Menon ◽  
Pradeep Jacob ◽  
Gopalakrishnan Nair C
Keyword(s):  
Thyroid Nodules ◽  
Needle Aspiration ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Aspiration Cytology ◽  
Cross Sectional ◽  
Fine Needle ◽  
Sestamibi Scintigraphy ◽  
Needle Aspiration Cytology ◽  
Thyroid Malignancies

BACKGROUND The diagnosis of thyroid malignancies continues to remain a challenge, due to lack of specificity with various modalities, and intrinsic variability with clinical examination. Although histopathological diagnosis is confirmatory, there is a need for pre-surgical assessment and confirmation, which will prove to be useful in decision making regarding the course of management. The present study was carried out to evaluate the validity of various modalities for detection of thyroid malignancies. METHODS This cross-sectional study was carried out among 40 patients who presented to the outpatient clinic with thyroid nodules. All the participants were evaluated by ultrasound, fine needle aspiration cytology (FNAC) and sestamibi scintigraphy. All the participants were taken up for surgery and the resected specimen was sent for histopathology for confirmatory diagnosis. RESULTS Ultrasound and FNAC detected malignancy in 25 % of the participants, while sestamibi scintigraphy detected malignancy in 30 % of the participants. Based on histopathology, the gold standard confirmatory test, malignancy was detected in 35 % of the participants. It was observed that the sensitivity was highest for FNAC (75 %) followed by TC methoxyisobutylisonitrile (TC MIBI) (50 %). Specificity was highest for FNAC (95 %) followed by ultrasound (88 %) (P < 0.0001). CONCLUSIONS FNAC has the highest sensitivity and specificity while ultrasound and sestamibi have comparable specificity. There is a high probability of malignancy when the delayed image in sestamibi scintigraphy shows retention. MIBI may prove to be useful in differentiating benign and malignant follicular lesions. KEYWORDS Papillary Carcinoma, Histopathology, Thyroid Nodule, Sestamibi, FNAC

scholarly journals Trends in symptomatology of thyroid malignancy in southern India and the efficacy of targeted fine needle aspiration cytology with ultrasonography guidance in diagnosis

2019 ◽  
Vol 6 (10) ◽  
pp. 3744
Author(s):  
C. Kiran Kailas ◽  
T. Nazareth Solomon ◽  
Punitha Thetraravu Oli ◽  
Sandeep Jose
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
The United States ◽  
Needle Aspiration ◽  
Cross Sectional Study ◽  
Thyroid Malignancy ◽  
Aspiration Cytology ◽  
Cross Sectional ◽  
Fine Needle ◽  
Needle Aspiration Cytology

Background: Thyroid cancers are on the rise all over the world. Studies have shown a tripling incidence of thyroid cancer in the United States in the past 35 years. Similar studies from Korea have also shown similar trends of 15 times increase in incidence. This study aims at assessing the recent trends in clinical presentation of thyroid malignancy and the efficacy of ultrasound targeted fine needle aspiration cytology (FNAC) in the diagnosis of thyroid malignancy.Methods: A cross sectional study was conducted involving 275 patients with thyroid disorders treated in the department of General Surgery at Dr. Somervell Memorial CSI Medical College, Trivandrum, India. Chi-square test was done for statistical test of significance and odds ratio for strength of association.Results: In this study group, 89% of the patients presented with swelling in front of the neck as chief complaint both in benign and malignancy. Swelling in front of the neck is the predominant symptom in thyroid malignancy. 52% of patients presented with the described symptoms of more than 6 months duration. The specificity of USG guided FNAC is 90% in diagnosing malignancy in goitre in this study group.Conclusions: The commonest symptom of thyroid malignancy was a painless swelling in the front of the neck. Most common thyroid pathology presenting as thyroid swelling was multinodular goitre. Nearly half of the patients presenting with symptoms more than 6 months had thyroid malignancy. FNAC under ultrasound guidance is an inexpensive accurate and practical investigation for evaluation of thyroid carcinomas.

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