Total Artificial Heart and Chronic Haemodialysis: A Possible Bridge to Transplantation?

2016 ◽  
Vol 42 (4) ◽  
pp. 301-303 ◽  
Author(s):  
Julien Demiselle ◽  
Virginie Besson ◽  
Johnny Sayegh ◽  
Jean-François Subra ◽  
Jean-François Augusto
Keyword(s):  
Artificial Heart ◽  
Human Leukocyte ◽  
High Rate ◽  
Total Artificial Heart ◽  
Chronic Haemodialysis ◽  
Leukocyte Antigen ◽  
Chronic Hemolysis ◽  
End Stage Heart Failure ◽  
End Stage

Background: Total artificial heart (TAH) device is sometimes necessary to treat end stage heart failure (HF). After surgery, renal impairment can occur with the need of renal replacement therapy. Method: We report the case of a 51-year-old man who was treated with conventional hemodialysis (HD) while on support with TAH. Results: The patient underwent HD while on TAH support during 14 months. He benefited from conventional HD, 6 sessions per week. HD sessions were well tolerated, and patient's condition and quality of life improved significantly. The main difficulty was to maintain red blood cell level because of chronic hemolysis due to TAH, which required repetitive blood transfusions, resulting in a high rate of human leukocyte antigen sensitization. Unfortunately, the patient died of mesenteric ischemia due to anticoagulation under dosing. Conclusion: We conclude that HD treatment is possible despite TAH and should be considered in patients with both end stage renal and HF.

scholarly journals Donor-recipient Matching in Heart Transplantation

2020 ◽  
Vol 14 (1) ◽  
pp. 42-47
Author(s):  
Aleksandra Oprzędkiewicz ◽  
Hubert Mado ◽  
Wioletta Szczurek ◽  
Mariusz Gąsior ◽  
Bożena Szyguła-Jurkiewicz
Keyword(s):  
Heart Transplantation ◽  
Perioperative Complications ◽  
Hla Antigens ◽  
Human Leukocyte ◽  
Abo Blood Group ◽  
Leukocyte Antigen ◽  
End Stage Heart Failure ◽  
End Stage ◽  
The Impact

Heart transplantation remains the treatment of choice for end-stage Heart Failure (HF). Due to the shortage of organs for transplantation and the occurrence of perioperative complications, a key problem is donor matching, which should result in increased survival and improved quality of life for patients. The success of this procedure depends on various parameters such as gender, weight, ABO blood group and Human Leukocyte Antigen (HLA) system of both the recipient and the donor. Furthermore, non-HLA antigens may also be valuable in donor-recipient matching. The aim of this article is to summarize the recent knowledge on the impact of various factors on accurate donor-recipient matching to heart transplantation.

The Biocompatibility Challenges in the Total Artificial Heart Evolution

2019 ◽  
Vol 21 (1) ◽  
pp. 85-110 ◽  
Author(s):  
Eleonora Dal Sasso ◽  
Andrea Bagno ◽  
Silvia T.G. Scuri ◽  
Gino Gerosa ◽  
Laura Iop
Keyword(s):  
Heart Failure ◽  
Artificial Heart ◽  
Comprehensive Analysis ◽  
Therapeutic Options ◽  
Total Artificial Heart ◽  
Final Treatment ◽  
End Stage Heart Failure ◽  
End Stage

There are limited therapeutic options for final treatment of end-stage heart failure. Among them, implantation of a total artificial heart (TAH) is an acceptable strategy when suitable donors are not available. TAH development began in the 1930s, followed by a dramatic evolution of the actuation mechanisms operating the mechanical pumps. Nevertheless, the performance of TAHs has not yet been optimized, mainly because of the low biocompatibility of the blood-contacting surfaces. Low hemocompatibility, calcification, and sensitivity to infections seriously affect the success of TAHs. These unsolved issues have led to the withdrawal of many prototypes during preclinical phases of testing. This review offers a comprehensive analysis of the pathophysiological events that may occur in the materials that compose TAHs developed to date. In addition, this review illustrates bioengineering strategies to prevent these events and describes the most significant steps toward the achievement of a fully biocompatible TAH.

Effect of a Total Artificial Heart on Adaptive Hormonal Responses in Humans with End-Stage Heart Failure

1989 ◽  
Vol 35 (3) ◽  
pp. 229-230 ◽  
Author(s):  
KEVIN D. MURRAY ◽  
P. DAVID MYEROWITZ ◽  
KIM M. WATSON ◽  
PATTY A. LOWE ◽  
LAURI K. KALANGES ◽  
...  
Keyword(s):  
Heart Failure ◽  
Artificial Heart ◽  
Total Artificial Heart ◽  
Hormonal Responses ◽  
End Stage Heart Failure ◽  
End Stage

Effect of a Total Artificial Heart on Adaptive Hormonal Responses in Humans with End-Stage Heart Failure

1989 ◽  
Vol 35 (3) ◽  
pp. 229-230
Author(s):  
KEVIN D. MURRAY ◽  
P. DAVID MYEROWITZ ◽  
KIM M. WATSON ◽  
PATTY A. LOWE ◽  
LAURI K. KALANGES ◽  
...  
Keyword(s):  
Heart Failure ◽  
Artificial Heart ◽  
Total Artificial Heart ◽  
Hormonal Responses ◽  
End Stage Heart Failure ◽  
End Stage

scholarly journals The Use of Total Artificial Heart With Example of Cases for End-Stage Heart Failure Therapy

2013 ◽  
Vol 62 (18) ◽  
pp. C45
Author(s):  
Serkan Ertugay ◽  
Özlem Balcıoğlu ◽  
Ayşen Yaprak Engin ◽  
Emrah Oğuz ◽  
Çağatay Engin ◽  
...  
Keyword(s):  
Heart Failure ◽  
Artificial Heart ◽  
Total Artificial Heart ◽  
Heart Failure Therapy ◽  
End Stage Heart Failure ◽  
End Stage

scholarly journals A bioprosthetic total artificial heart for end-stage heart failure: Results from a pilot study

2018 ◽  
Vol 37 (1) ◽  
pp. 33-37 ◽  
Author(s):  
Christian Latrémouille ◽  
Alain Carpentier ◽  
Pascal Leprince ◽  
Jean-Christian Roussel ◽  
Bernard Cholley ◽  
...  
Keyword(s):  
Heart Failure ◽  
Pilot Study ◽  
Artificial Heart ◽  
Total Artificial Heart ◽  
End Stage Heart Failure ◽  
End Stage

Kidney Transplantation 1: An Overview--Recipient Evaluation and Immunosuppression

2017 ◽  
Author(s):  
Belinda T. Lee ◽  
Anil Chandraker ◽  
Jamil Azzi ◽  
Martina M McGrath
Keyword(s):  
Kidney Transplantation ◽  
Human Leukocyte ◽  
Basic Knowledge ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Early Management ◽  
Leukocyte Antigen ◽  
Medical Evaluation ◽  
Stage Renal Disease ◽  
End Stage

Kidney transplantation remains the optimal renal replacement therapy for patients with end-stage renal disease (ESRD). A timely referral to kidney transplantation and a thorough pretransplantation evaluation ensure improvement in the morbidity and mortality of ESRD patients. Basic knowledge of immune biology and an in-depth understanding of the different induction and maintenance therapies used post kidney transplantation are imperative for optimal patient management. In this review, we discuss the multidisciplinary process of pretransplantation evaluation of kidney transplant recipients. We also discuss state-of–the-art early management post kidney transplantation with the different immunosuppressive therapies currently available. This review contains 3 figures, 11 tables, and 106 references. Key words: crossmatch, donor-specific antibody, immunosuppression, human leukocyte antigen, immunosuppression, induction, maintenance, medical evaluation, transplantation

Plasmapheresis Therapy in Kidney Transplant Rejection

2018 ◽  
Vol 47 (1-3) ◽  
pp. 73-84 ◽  
Author(s):  
Pan Xie ◽  
Min Tao ◽  
Kanfu Peng ◽  
Hongwen Zhao ◽  
Keqin Zhang ◽  
...  
Keyword(s):  
End Stage Renal Disease ◽  
Multimodal Treatment ◽  
Transplant Rejection ◽  
Human Leukocyte ◽  
Economic Costs ◽  
Leukocyte Antigen ◽  
Antibody Mediated Rejection ◽  
Stage Renal Disease ◽  
End Stage ◽  
Optimal Treatment Strategy

Kidney transplantation (KT) is considered an optimal treatment strategy for end-stage renal disease. But human leukocyte antigen-sensitized, ABO-incompatible and antibody-mediated rejection might be the alarming hurdles in KT. Therapeutic plasma exchange is the mainstay of the antibody reduction therapy for reducing autoantibody more effectively. Even in the treatment for highly sensitized patients, it has played an indispensable role. However, clinicians should tailor therapies to individual patient’s needs and multimodal treatment will bring better outcomes. Early diagnosis and precise treatment would reduce morbidity, mortality, and economic costs.

scholarly journals PENGEMBANGAN KAPASITAS PEREMPUAN BAGI IBU-IBU RELAWAN PROGRAM PALIATIF DI DESA KAMBINGAN DAN DESA KREMBUNG, KECAMATAN CERME, KABUPATEN GRESIK

2020 ◽  
Vol 4 (1) ◽  
pp. 189
Author(s):  
Sulikah Asmorowati ◽  
Inge Dhamanty
Keyword(s):  
Palliative Care ◽  
High Rate ◽  
World Health ◽  
Target Area ◽  
Target Groups ◽  
Community Project ◽  
Health Organization ◽  
End Stage

The high rate of deaths caused by serious illnesses has led the World Health Organization (WHO) to recommend palliative care that is considered to be able to improve the quality of patient’s live Palliative care or service is service for patients with serious illnesses, such as cancer (stadium or end-stage). In this activity, however, palliative care and service is extended so that it includes diseases that are not contagious but deadly (thus, contributed significantly to mortality rate), including such illnesses as diabetes, high-blood pressure, cholesterol, stroke and other similar illnesses. These illnesses are now increasingly being suffered by and become the major cause of death (caused by illnesses) amongst Indonesians. In order to increase the availability of palliative services in the target area, this community project provides training and assistance to develop women’s capacity in the villages of Kambingan and Ngembung, Cerme, Gresik, so that they are ready to volunteers for palliative care and service in their respective communities. The projects were conducted by providing material through lectures, and modules; followed by assistance to form a team of palliative case and service. At the end, this project resulted in the increasing understanding, and capacity of women (and mothers or PKK member), as the target groups about palliative care and services. In turn, the women were then ready to become volunteers for palliative care and program.abstrakTingginya tingkat kematian akibat penyakit serius membuat WHO menyarankan untuk melakukan perawatan paliatif yang dianggap dapat meningkatkan kualitas hidup pasien. Program atau layanan paliatif adalah pelayanan kepada pasien dengan penyakit berat, yaitu kanker (stadium akhir). Dalam kegiatan pengabdian masyarakat (pengmas) ini, layanan paliatif diperluas sehingga meliputi pula penyakit-penyakit yang tidak menular namun mematikan, seperti penyakit diabates, darah tinggi, kolesterol, stroke dan sejenisnya yang dewasa ini semakin banyak di derita masyarakat Indonesia. Kegiatan pengmas ini memberikan pelatihan dan pendampingan untuk mengembangkan kapasitas ibu-ibu tim penggerak dan anggota PKK di Desa Kambingan dan Desa Ngembung, Kecamatan Cerme, Kabupaten Gresik agar siap untuk menjadi relawan program paliatif di lingkungan masyarakat masing-masing. Metode yang digunakan dalam kegiatan ini adalah dengan pemberian materi melalui ceramah, pemberian modul, serta pendampingan pembentukan tim paliatif sebagai follow-up kegiatan. Hasil yang dicapai dari kegiatan pengabdian masyarakat ini adalah meningkatnya pemahaman masyarakat khususnya ibu-ibu tentang layanan paliatif, serta meningkatnya kapasitas mereka,sehingga siap menjadi relawan program paliatif.

Current state of total artificial heart therapy and introduction of the most important total artificial heart systems

2019 ◽  
Vol 64 (3) ◽  
pp. 247-250
Author(s):  
Sotirios Spiliopoulos ◽  
Vera Hergesell ◽  
Andrae Wasler ◽  
Otto Dapunt
Keyword(s):  
Heart Failure ◽  
Organ Donation ◽  
Clinical Outcomes ◽  
Artificial Heart ◽  
Cardiac Transplantation ◽  
Total Artificial Heart ◽  
Successful Implementation ◽  
Technical Requirements ◽  
Current State ◽  
End Stage

AbstractDue to the declining instances of organ donation, total artificial heart (TAH) therapy is of increasing importance for the management of end-stage biventricular heart failure. We introduce the currently most important established and novel TAH systems (SynCardia, CARMAT, ReinHeart, BiVACOR), report clinical outcomes and discuss technical requirements for the successful implementation of TAH therapy as an alternative to cardiac transplantation.

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