Capsaicin Used on Skin Influences Ion Transport Pathways: An in vitro Study

2017 ◽  
Vol 31 (1) ◽  
pp. 19-27 ◽  
Author(s):  
Iga Hołyńska-Iwan ◽  
Inga Dziembowska ◽  
Paulina Smyk ◽  
Magdalena Lampka ◽  
Dorota Olszewska-Słonina
2007 ◽  
Vol 293 (1) ◽  
pp. H126-H132 ◽  
Author(s):  
Limary M. Cancel ◽  
Andrew Fitting ◽  
John M. Tarbell

It is difficult to assess the transport pathways that carry low-density lipoprotein (LDL) into the artery wall in vivo, and there has been no previous in vitro study that has examined transendothelial transport under physiologically relevant pressurized (convective) conditions. Therefore, we measured water, albumin, and LDL fluxes across bovine aortic endothelial cell (BAEC) monolayers in vitro and determined the relative contributions of vesicles, paracellular transport through “breaks” in the tight junction, and “leaky” junctions associated with dying or dividing cells. Our results show that leaky junctions are the dominant pathway for LDL transport (>90%) under convective conditions and that albumin also has a significant component of transport through leaky junctions (44%). Transcellular transport of LDL by receptor-mediated processes makes a minor contribution (<10%) to overall transport under convective conditions.


2018 ◽  
Vol 148 ◽  
pp. 144-150 ◽  
Author(s):  
Iga Hołyńska-Iwan ◽  
Joanna Bogusiewicz ◽  
Dagmara Chajdas ◽  
Karolina Szewczyk-Golec ◽  
Magdalena Lampka ◽  
...  

2020 ◽  
Vol 129 ◽  
pp. 110502
Author(s):  
Iga Hołyńska-Iwan ◽  
Marta Sobiesiak

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
EM Pferschy-Wenzig ◽  
K Koskinen ◽  
C Moissl-Eichinger ◽  
R Bauer

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