The Derived Neutrophil-to-Lymphocyte Ratio Is an Independent Prognostic Factor in Transplantation Ineligible Patients with Multiple Myeloma

2018 ◽  
Vol 140 (3) ◽  
pp. 146-156 ◽  
Author(s):  
Gyeong-Won Lee ◽  
Sung Woo Park ◽  
Se-Il Go ◽  
Hoon-Gu Kim ◽  
Min Kyoung Kim ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Prognostic Factor ◽  
Prognostic Marker ◽  
Complete Blood Count ◽  
Complete Response ◽  
Neutrophil To Lymphocyte Ratio ◽  
Characteristic Analysis ◽  
Poor Prognostic Factor ◽  
Lymphocyte Ratio ◽  
Hematological Cancers

Background: The neutrophil-to-lymphocyte ratio (NLR) is an independent prognostic marker in solid and hematological cancers. While the derived NLR (dNLR) was shown to be non-inferior to the NLR in large cohorts of patients with different cancer types, it has not been validated as a prognostic marker for multiple myeloma (MM) to date. Methods: Between May 22, 2011 and May 29, 2014, 176 patients with MM from 38 centers who were ineligible for autologous stem cell transplantation were analyzed. The dNLR was calculated using complete blood count differential data. The optimal dNLR cut-off value according to receiver operating characteristic analysis of overall survival (OS) was 1.51. All patients were treated with melphalan and prednisone combined with bortezomib. Results: The complete response rate was lower in the high dNLR group compared to the low dNLR group (7 vs. 26.1%, respectively; p = 0.0148); the corresponding 2-year OS rates were 72.2 and 84.7%, respectively (p = 0.0354). A high dNLR was an independent poor prognostic factor for OS (hazard ratio 2.217, 95% CI 1.015–4.842; p = 0.0458). Conclusion: The dNLR is a readily available and cheaply obtained parameter in clinical studies, and shows considerable potential as a new prognostic marker for transplantation-ineligible patients with MM.

Could the neutrophil to lymphocyte ratio be a poor prognostic factor for lung cancers?

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. e19145-e19145
Author(s):  
Turgut Kacan ◽  
Nalan Babacan ◽  
Mehmet Metin Seker ◽  
Birsen Yucel ◽  
Aykut Bahceci ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Neutrophil To Lymphocyte Ratio ◽  
Poor Prognostic Factor ◽  
Lung Cancers ◽  
Lymphocyte Ratio

Neutrophil-to-Lymphocyte Ratio as a Poor Prognostic Factor in Iranian COVID-19 Patients

2021 ◽  
Vol 67 (02/2021) ◽  
Author(s):  
Ebrahim Kouhsari ◽  
Nourkhoda Sadeghifard ◽  
Mohammad Karimian ◽  
Hojjat Sayyadi ◽  
Ali Nazari ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Neutrophil To Lymphocyte Ratio ◽  
Poor Prognostic Factor ◽  
Lymphocyte Ratio

Association of ascitic neutrophil to lymphocyte ratio with prognosis in patients with advanced gastric cancer

2020 ◽  
Vol 38 (4_suppl) ◽  
pp. 443-443
Author(s):  
Jae-Joon Kim ◽  
So Yeon Oh ◽  
Kwonoh Park ◽  
Sang-Bo Oh
Keyword(s):  
Gastric Cancer ◽  
Prognostic Factor ◽  
Prognostic Significance ◽  
Metastatic Gastric Cancer ◽  
Malignant Ascites ◽  
Initial Result ◽  
Neutrophil To Lymphocyte Ratio ◽  
Poor Prognostic Factor ◽  
Lymphocyte Ratio ◽  
Gastric Cancer Patients

443 Background: Approximately 40% of metastatic gastric cancer patients develop peritoneal carcinomatosis, and this condition leads patients to grave prognosis. Blood neutrophil to lymphocyte ratio (NLR) is associated with prognosis in various solid tumors, such as non-small cell lung cancer, colorectal cancer, and gastric cancer. We performed this study to investigate the prognostic significance of NLR of ascitic fluid. Methods: This is retrospective study. Patients were consecutive included if they; 1) had histologically confirmed gastric adenocarcinoma, poorly cohesive carcinoma, or poorly differentiated carcinoma, 2) were relapsed after curative resection or initially metastatic, 3) had ascites due to peritoneal metastases of gastric cancer, 4) had received paracentesis at least once and the result of ascites exam is available. Patients with clinically active infection in the time of paracentesis is excluded. If multiple times of paracentesis was done, we used initial result. Results: From March 2012 to August 2018, total 157 patients who were visited in Pusan National University Yangsan Hospital met the inclusion criteria. Median age is 58 (29-86) years and male patients was 63% (n = 99). In 38.9% (n = 61) patients, gastric cancer was diagnosed in primary site and in ascites synchronously. At the time of first paracentesis, 47.1% (n = 74) of patients had already been received palliative chemotherapy due to metastatic gastric cancer. In the ascites, mean and median NLR is 2.2±6.8 and 0.3 (0-65). All except 3 patients were expired, and the median survival time form paracentesis was 47 (95% confidence interval 38.6-55.4) days. In the Kaplan-Meier survival analysis, patients with higher NLR (≥0.33) have shorter survival from paracentesis (39 days, 95% CI 32.5-45.4) in compared to lower NLR ( < 0.33) (61 days, 95% CI 29.4-92.6, log-rank p = 0.011). In the additional analyses, higher neutrophil count (41 vs 72 days, p = 0.045) and lower protein level (32 vs 61 days, p = 0.018) of ascites are also poor prognostic factor. Conclusions: High NLR of malignant ascites is poor prognostic factor in patients with gastric cancer. The role of neutrophil in the malignant ascites should be tested in a new perspective.

scholarly journals Neutrophil to Lymphocyte Ratio as Prognostic and Predictive Factor in Breast Cancer Patients: A Systematic Review

Cancers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 958
Author(s):  
Iléana Corbeau ◽  
William Jacot ◽  
Séverine Guiu
Keyword(s):  
Breast Cancer ◽  
Prognostic Factor ◽  
Predictive Factor ◽  
Complete Response ◽  
Neutrophil To Lymphocyte Ratio ◽  
Published Data ◽  
Breast Cancer Patients ◽  
Lymphocyte Ratio ◽  
Neo Adjuvant Chemotherapy ◽  
Invasive Evaluation

Inflammatory blood markers (IBM), such as the neutrophil to lymphocyte ratio (NLR), have emerged as potential prognostic factors in various cancers, including breast cancer (BC), potentially allowing an easy, minimally invasive evaluation of a given cancer‘s prognosis and treatment outcome. We report here a systematic overview of the published data evaluating NLR as a prognostic factor or predictive factor for pathological complete response (PCR) and toxicity in early and advanced BC. A total of 45 articles were identified. NLR was found to be an independent prognostic factor for survival in most of the adjuvant treatment studies. However, no significant correlation was found between survival and NLR for early BC patients receiving neo-adjuvant chemotherapy (NACT) and advanced BC patients. Most studies failed to find a significant correlation between NLR and PCR after NACT. Finally, some data showed that IBM could be predictive of chemotherapy-related toxicity.

scholarly journals Could the Neutrophil to Lymphocyte Ratio be a Poor Prognostic Factor for Non Small Cell Lung Cancers?

2014 ◽  
Vol 15 (5) ◽  
pp. 2089-2094 ◽  
Author(s):  
Turgut Kacan ◽  
Nalan Akgul Babacan ◽  
Metin Seker ◽  
Birsen Yucel ◽  
Aykut Bahceci ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Small Cell ◽  
Neutrophil To Lymphocyte Ratio ◽  
Small Cell Lung ◽  
Poor Prognostic Factor ◽  
Lung Cancers ◽  
Lymphocyte Ratio

scholarly journals Pretreatment Neutrophil-to-Lymphocyte Ratio Associated with Tumor Recurrence and Survival in Patients Achieving a Pathological Complete Response Following Neoadjuvant Chemoradiotherapy for Rectal Cancer

Cancers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 4589
Author(s):  
Chun-Ming Huang ◽  
Ming-Yii Huang ◽  
Hsiang-Lin Tsai ◽  
Ching-Wen Huang ◽  
Wei-Chih Su ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Tumor Recurrence ◽  
Pathological Complete Response ◽  
Locally Advanced ◽  
Neoadjuvant Chemoradiotherapy ◽  
Complete Response ◽  
Cox Proportional Hazards Model ◽  
Neutrophil To Lymphocyte Ratio ◽  
Poor Prognostic Factor ◽  
Lymphocyte Ratio

The clinical influence of the neutrophil-to-lymphocyte ratio (NLR) in predicting outcomes in patients with locally advanced rectal cancer (LARC) who achieve a pathological complete response (pCR) to neoadjuvant chemoradiotherapy (NACRT) has seldom been investigated. We retrospectively recruited 102 patients with LARC who achieved a pCR to NACRT and the association of NLR status with survival and tumor recurrence in the patients was analyzed. Thirteen patients (12.7%) developed tumor recurrence. A high NLR (≥3.2) was significantly associated with tumor recurrence (p = 0.039). The 5-year OS rates in patients with a low NLR and patients with a high NLR were 95.1% and 77.7%, respectively (p = 0.014); the 5-year DFS rates in patients with low NLR and patients with a high NLR were 90.6% and 71.3%, respectively (p = 0.031). The Cox proportional hazards model indicated that an NLR of ≥3.2 was an independent poor prognostic factor for DFS (hazard ratio [HR] = 3.12, 95% confidence interval [CI] = 1.06–9.46, p = 0.048) and OS (HR = 6.96, 95% CI = 1.53–35.51, p = 0.013). A pretreatment high NLR (≥3.2) was a promising predictor of reduced OS and DFS in patients with LARC who achieved a pCR to NACRT.

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