Clinicopathological Characteristics, Role of Immunosuppressive Therapy and Progression in IgA Nephropathy with Hyperuricemia

Colorectal cancer (CRC) is ranked as the second most commonly diagnosed disease in females and the third in males worldwide. Therefore, the finding of new more reliable biomarkers for early diagnosis, for prediction of metastasis, and resistance to conventional therapies is an important challenge in overcoming the disease. The current review presents circular RNAs (circRNAs) with their unique features as potential prognostic and diagnostic biomarkers in CRC. The review highlights the mechanism of action and the role of circRNAs with oncogenic functions in the CRC as well as the association between their expression and clinicopathological characteristics of CRC patients. The comprehension of the role of oncogenic circRNAs in CRC pathogenesis is growing rapidly and the next step is using them as suitable new drug targets in the personalized treatment of CRC patients.

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Enumerating the role of properdin in the pathogenesis of IgA nephropathy and its possible therapies

International Immunopharmacology ◽

10.1016/j.intimp.2021.107429 ◽

2021 ◽

Vol 93 ◽

pp. 107429

Author(s):

Srijit Ghosh ◽

Srijita Das ◽

Joy Mukherjee ◽

Salik Abdullah ◽

Rupsa Mondal ◽

...

Keyword(s):

Iga Nephropathy

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The role of tonsillectomy in IgA nephropathy

Journal of Nephrology ◽

10.1007/s40620-015-0247-4 ◽

2015 ◽

Vol 29 (1) ◽

pp. 13-19 ◽

Cited By ~ 9

Author(s):

Sandro Feriozzi ◽

Rosaria Polci

Keyword(s):

Iga Nephropathy

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The Role of Immunosuppressive Therapy in Aneurysmal Degeneration of Hemodialysis Fistulas in Renal Transplant Patients

Annals of Vascular Surgery ◽

10.1016/j.avsg.2021.01.097 ◽

2021 ◽

Author(s):

Alessia Viscardi ◽

Antonio Travaglino ◽

Luca del Guercio ◽

Maria D'Armiento ◽

Michele Santangelo ◽

...

Keyword(s):

Renal Transplant ◽

Immunosuppressive Therapy ◽

Transplant Patients ◽

Renal Transplant Patients ◽

Hemodialysis Fistulas

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Questionable Role of Soy Protein in Childhood IgA Nephropathy

Nephron ◽

10.1159/000187360 ◽

1993 ◽

Vol 64 (3) ◽

pp. 395-398 ◽

Cited By ~ 1

Author(s):

T. Murakami ◽

H. Kawakami

Keyword(s):

Iga Nephropathy ◽

Soy Protein ◽

Childhood Iga Nephropathy

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Long non-coding RNA FTX predicts a poor prognosis of human cancers: a meta-analysis

Bioscience Reports ◽

10.1042/bsr20203995 ◽

2021 ◽

Author(s):

Weiwei Chen ◽

Yuting Li ◽

Liliangzi Guo ◽

Chenxing Zhang ◽

Shaohui Tang

Keyword(s):

Meta Analysis ◽

Clinical Stage ◽

Predictive Marker ◽

Clinicopathological Characteristics ◽

Cochrane Library ◽

Hazard Ratios ◽

Non Coding Rna ◽

The Relationship ◽

Long Non Coding Rna

Background: Several studies have assessed the relationship between long non-coding RNA five prime to Xist (FTX) expression, clinicopathological features, and survival outcomes in cancer patients with conflicting results. This meta-analysis synthesized existing data to clarify the association between FTX with cancer prognosis.Methods: PubMed, Embase, Cochrane library, Web of Science, Chinese CNKI, and the Chinese WanFang databases were used to search for relevant studies. Role of FTX in cancers was evaluated by pooled odds ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals (CIs).Results: Eleven studies comprising 1,210 participants including colorectal cancer (CRC), hepatocellular carcinoma (HCC), gastric cancer (GC), renal cell carcinoma (RCC), osteosarcoma (OSC), and glioma were enrolled in this analysis. The meta-analysis showed that high FTX expression was significantly associated with several clinicopathological characteristics, including lymph node metastasis in patients with CRC, GC, HCC, and RCC, distant metastasis in patients with CRC, GC, HCC, and OSC, larger tumor size in patients with CRC, GC, HCC, RCC, and OSC, and subsequently TNM/clinical stage in patients with CRC, GC, HCC, OSC, and glioma. The pooled results from the survival analysis revealed a significant correlation between high FTX expression and shorter OS in patients with HCC, CRC, GC, OSC, and glioma. Further, FTX overexpression could be an independent predictive marker for shorter OS in patients with CRC, HCC, OSC, and glioma. Conclusions: FTX may be a potential oncogene, with high FTX expression being associated with a poorer prognosis in patients with CRC, HCC, OSC, and glioma

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Reduced fecal short-chain fatty acids levels and the relationship with gut microbiota in IgA nephropathy

10.21203/rs.3.rs-373656/v1 ◽

2021 ◽

Author(s):

Lingxiong Chai ◽

Qun Luo ◽

Kedan Cai ◽

Kaiyue Wang ◽

Binbin Xu

Keyword(s):

Gut Microbiota ◽

Iga Nephropathy ◽

Butyric Acid ◽

Intestinal Flora ◽

Short Chain Fatty Acids ◽

Caproic Acid ◽

Isobutyric Acid ◽

Control Group ◽

Β Diversity

Abstract Background: IgA nephropathy(IgAN)) is the common pathological type of glomerular diseases. The role of gut microbiota in mediating "gut-IgA nephropathy" has not received sufficient attention in the previous studies. The purpose of this study was to investigate the changes of fecal short-chain fatty acids(SCFAs), a metabolite of the intestinal microbiota, in patients with IgAN and its correlation with intestinal flora and clinical indicators, and to further investigate the role of the gut-renal axis in IgAN.Methods: There were 29 patients with IgAN and 29 normal control subjects recruited from January 2018 to May 2018. The fresh feces were collected. The fecal SCFAs were measured by gas chromatography/mass spectrometry and gut microbiota was analysed by16S rDNA sequences, followed by estimation of α- and β-diversity. Correlation analysis was performed using the spearman’s correlation test between SCFAs and gut microbiota. Results:The levels of acetic acid, propionic acid, butyric acid, isobutyric acid and caproic acid in the IgAN patients were significantly reduced compared with control group(P<0.05). Butyric acid(r=-0.336, P=0.010) and isobutyric acid(r=-0.298, P=0.022) were negatively correlated with urea acid; butyric acid(r=-0.316, P=0.016) was negatively correlated with urea nitrogen; caproic acid(r=-0.415,P=0.025) showed negative correlation with 24-h urine protein level.Exemplified by the results of α-diversity and β-diversity, the intestinal flora of IgAN patients was significantly different from that of the control group. Acetic acid was positively associated with c_Clostridia(r=0.357, P=0.008), o_Clostridiales(r=0.357, P=0.008) and g_Eubacterium_coprostanoligenes_group(r=0.283, P=0.036). Butyric acid was positively associated with g_Alistipes (r=0.278, P=0.040). The relative abundance of those were significantly decreased in IgAN group compared to control group.Conclusion: The levels of fecal SCFAs in the IgAN patients were reduced, and correlated with clinical parameters and gut microbiota, which may be involved in the pathogenesis of IgAN, and this finding may provide a new therapeutic approach.

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