Influence of Chronic Coenzyme Q10 Supplementation on Cognitive Function, Learning, and Memory in Healthy and Diabetic Middle-Aged Rats

Diabetes mellitus has a major impact on the brain and its cognitive function. The pathogenesis of these disorders is still not well understood. Therefore, it is necessary to find ways of solving these manifestations in hyperglycemia in order to prevent the risk of complications that will lead to a worsening of living conditions. In the experiment, the state of conditioned-reflex and orientation-research activity of rats of different ages (middle-aged rats and old rats) in conditions of experimental hyperglycemia was found. The animals were kept under standard vivarium conditions. Experimental hyperglycemia was modeled by intraperitoneal solution injection of alloxan monohydrate (120 mg/kg body weight, Sigma). For 10 days, blood glucose was determined using a portable glucometer «Bionime». On day 10, those animals were selected that had a blood glucose value above 28 mmol/L. The analysis of orientation-research and emotional activity was carried out using the «Open Field» technique. The number of squares crossed, the number of lifts on the hind legs, the number of peeking into the burrows, grooming, and the number of bowel movements were recorded. The conditioned passive avoidance technique was used to study the stable and labile phases of memory. In both age groups, the indicators of orientation-research activity differed significantly (p < 0.05). The decrease in the number of squares crossed, the number of racks up and the study of minks was more pronounced in middle-aged animals with diabetes mellitus. The increase in the number of amnesiac animals was also more pronounced in the middle-aged rats of the research group. A decrease in the latency period was noted in both age groups. Thus, it was found that experimental hyperglycemia had pronounced consequences for the cognitive function of animals, respectively, diabetes mellitus has a negative effect on the brain.

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Blockade of hippocampal bradykinin B1 receptors improves spatial learning and memory deficits in middle-aged rats

Behavioural Brain Research ◽

10.1016/j.bbr.2016.08.041 ◽

2017 ◽

Vol 316 ◽

pp. 74-81 ◽

Cited By ~ 6

Author(s):

Rafael M. Bitencourt ◽

Ana C. Guerra de Souza ◽

Maíra A. Bicca ◽

Fabrício A. Pamplona ◽

Nelson de Mello ◽

...

Keyword(s):

Learning And Memory ◽

Spatial Learning ◽

Memory Deficits ◽

Spatial Learning And Memory ◽

Aged Rats ◽

Middle Aged ◽

B1 Receptors ◽

Learning And Memory Deficits

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Diabetes Mellitus Impairs Cognitive Function in Middle-Aged Rats and Neurological Recovery in Middle-Aged Rats After Stroke

Stroke ◽

10.1161/strokeaha.115.012578 ◽

2016 ◽

Vol 47 (8) ◽

pp. 2112-2118 ◽

Cited By ~ 41

Author(s):

Li Zhang ◽

Michael Chopp ◽

Yanlu Zhang ◽

Ye Xiong ◽

Chao Li ◽

...

Keyword(s):

Diabetes Mellitus ◽

Cognitive Function ◽

Neurological Recovery ◽

Aged Rats ◽

Middle Aged

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Vascular drug found to improve learning and memory in middle-aged rats: Drug has been well tolerated in humans for years

PsycEXTRA Dataset ◽

10.1037/e511842009-001 ◽

2009 ◽

Keyword(s):

Learning And Memory ◽

Aged Rats ◽

Middle Aged

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Individuals with and without Normal Tension Glaucoma Exhibit Comparable Performance on Tests of Cognitive Function

10.1101/2020.07.17.20154468 ◽

2020 ◽

Author(s):

Qi N Cui ◽

David Green ◽

Mohit Jethi ◽

Travis Porco ◽

Jane Kuo ◽

...

Keyword(s):

Executive Function ◽

Cognitive Function ◽

Optic Nerve ◽

Learning And Memory ◽

Charlson Comorbidity Index ◽

Verbal Learning ◽

Normal Tension Glaucoma ◽

Function Learning ◽

Department Of Ophthalmology ◽

Comorbidity Index

Aim: Glaucoma and dementia are both age-related neurodegenerative diseases with significant societal impact. Despite evidence suggesting an association between normal tension glaucoma (NTG) and dementia, lack of consensus remains due to conflicting reports. This cross-sectional cohort study administered a battery of neurocognitive tests targeting executive function, learning, and memory in subjects with NTG and unaffected controls to evaluate aspects of cognition impacted by dementia. Methods: Fifty NTG and 50 control patients ≥ 50 years of age were recruited from the UCSF Department of Ophthalmology. Demographic data and glaucoma parameters were extracted from electronic medical records for both groups. Tests of executive function (Executive Abilities: Measures and Instruments for Neurobehavioral Evaluation and Research [EXAMINER]) and learning and memory (California Verbal Learning Test Second Edition [CVLT II]) were administered to both NTG and Controls. Race, handedness, best-corrected visual acuity, maximum intraocular pressure, optic nerve cup to disc ratio, visual field and optic nerve optical coherence tomography parameters, and a measure of general health (Charlson Comorbidity Index) were compared between NTG and Controls as well as within NTG subgroups. Multivariate linear regression was used to compare group performances on the EXAMINER battery and CVLT II while controlling for age, sex, and years of education. Results: NTG and Controls were comparable with respect to age, sex, race, education, handedness, and the Charlson Comorbidity Index (p>0.05 for all). Performance on the EXAMINER composite score and the CVLT II did not differ between NTG and Controls (p>0.05 for both). Conclusions: This is the first prospective study in which the cognitive function of subject with NTG were evaluated using a comprehensive, computerized neurocognitive battery. Subjects with NTG subjects did not perform worse than unaffected controls on tests of executive function, learning, and memory. Results do not support the hypothesis that individuals with NTG are at higher risk for cognitive dysfunction and/or dementia.

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Tadalafil modulates intracerebroventricular streptozotocin-induced cognition and memory impairment in the young and middle middle-aged rats

Pharmaceutical Sciences ◽

10.34172/ps.2021.8 ◽

2021 ◽

Author(s):

Siamak Shahidi ◽

Masoumeh Asadbegi ◽

Nasrin Hashemi-Firouzi ◽

Alireza Komaki ◽

Minoo Mahmoodi

Keyword(s):

Learning And Memory ◽

Memory Impairment ◽

Cognitive Learning ◽

Cyclic Guanosine Monophosphate ◽

Guanosine Monophosphate ◽

Aged Rats ◽

Middle Aged ◽

Male Wistar Rats ◽

Significant Impairment ◽

Aged Subjects

Background: Learning and memory may decline due to Alzheimer’s disease (AD) in older adults. A reduction in cyclic guanosine monophosphate concentration and an increase in phosphodiesterase activity have been reported in the process of aging. Although phosphodiesterase (PDE) type 5 inhibitor, Tadalafil is used to treat erectile dysfunction; PDE inhibitors possibly prevent cognition impairment in aging. This study was designed to investigate the effects of tadalafil on memory in middle-aged and young healthy and AD rats. Methods: Memory impairment was induced by intracerebroventricular (ICV) administration of streptozotocin (STZ; 3 mg/kg) in AD rats. Male Wistar rats (middle-aged and young) were distributed into six groups as follows: two control, two AD, and two AD+tadalafil (1 mg/kg) groups. Saline or tadalafil was administered once a day orally for 40 consecutive days. Animals were tested using novel object recognition (NOR), passive avoidance learning (PAL), and Morris water maze (MWM) tests. Results: Aged AD rats exhibited a significant impairment in cognition in the NOR test and impaired learning and memory in PAL and MWM tests compared with the control aged rats. Tadalafil treatment in aged AD rats significantly improved the discrimination index in the NOR test, decreased the time spent in the dark compartment in the PAL test, and increased time spent in the target quadrant in MWM tests compared with aged AD rats. In young AD rats, treatment with tadalafil significantly enhanced cognition, learning, and memory in the NOR, PAL, and MWM tests compared with young AD rats treated with saline. Conclusion: Tadalafil treatment in aged rats improves cognition and memory after STZ-induced (ICV) memory impairment. It can be concluded that chronic treatment with tadalafil is protective against cognitive, learning, and memory impairment in both young and aged subjects.

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