scholarly journals Association between Growth Differentiation Factor 15 and Non-Dipping Circadian Pattern in Patients with Newly Diagnosed Essential Hypertension

2019 ◽  
Vol 28 (6) ◽  
pp. 566-572 ◽  
Author(s):  
Erdoğan Sökmen ◽  
Cahit Uçar ◽  
Serkan Sivri ◽  
Mustafa Çelik ◽  
Yalçın Boduroğlu ◽  
...  
Keyword(s):  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Newly Diagnosed ◽  
Growth Differentiation Factor 15 ◽  
Differentiation Factor ◽  
Linear Correlation Analysis ◽  
Normotensive Subjects ◽  
Relationship Of ◽  
Independent Marker ◽  
The Relationship

Objective: Non-dipper hypertension (HT) confers greater risk compared with dipper HT. Growth differentiation factor 15 (GDF-15) recently emerged as a novel and independent marker of cardiovascular disease, both in diagnostic and prognostic scopes. Our aim was to evaluate the relationship of circadian blood pressure (BP) pattern with serum GDF-15 level in newly diagnosed HT patients without left ventricular hypertrophy. Subjects and Methods: Newly diagnosed non-dipper (n = 66) and dipper (n = 60) HT patients were selected according to 24-h ambulatory BP monitoring (ABPM). The controls comprised healthy normotensive subjects (n = 31). Data was collected through physical examination, laboratory analysis, ABPM, and echocardiography. GDF-15 was measured using ELISA. Results: Greater GDF-15 level was found in the non-dippers compared with the dippers and the controls (557.53 ± 91.7, 513.79 ± 62.86, and 494.44 ± 79.30 ng/L, respectively, p < 0.001). In bivariate linear correlation analysis, GDF-15 correlated positively with glomerular filtration rate (r = 0.180, p =0.030), total cholesterol (r = 0.170, p = 0.038), septal E/E′ ratio (r = 0.344, p = 0.001), lateral E/E′ ratio (r = 0.366, p < 0.001), nighttime systolic BP (r = 0.166, p = 0.046), and nighttime diastolic BP (r = 0.188, p = 0.024); however, it correlated negatively with septal and lateral E′ velocities (r = 0.268, p = 0.005 and r = 0.236, p = 0.013, respectively). Furthermore, GDF-15 level and nighttime diastolic BP remained independently associated with non-dipper HT. In ROC analysis, optimal cutoff value for GDF-15 was 524.6 ng/L with 56.7% sensitivity and 72.4% specificity (AUC: 0.676, 95% CI: 0.580–0.772, p < 0.05). Conclusion: Our results showed GDF-15 upregulation in the non-dipper HT group. GDF-15 and nighttime diastolic BP were independently associated with the non-dipping pattern. This study may suggest possible utilization of GDF-15 in the prediction of non-dipper HT.

The relationship of electrocardiographic left ventricular hypertrophy to decreased serum potassium

2012 ◽  
Vol 21 (3) ◽  
pp. 146-152 ◽  
Author(s):  
Peter M. Okin ◽  
Sverre E. Kjeldsen ◽  
Lars H. Lindholm ◽  
Björn Dahlöf ◽  
Richard B. Devereux
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Serum Potassium ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Relationship Of ◽  
The Relationship

The haplotype of the growth-differentiation factor 15 gene is associated with left ventricular hypertrophy in human essential hypertension

2009 ◽  
Vol 118 (2) ◽  
pp. 137-145 ◽  
Author(s):  
Xiaojian Wang ◽  
Xu Yang ◽  
Kai Sun ◽  
Jingzhou Chen ◽  
Xiaodong Song ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Population Sample ◽  
Pressure Overload ◽  
Left Ventricular ◽  
Luciferase Reporter ◽  
Growth Differentiation Factor 15 ◽  
Transcription Activity ◽  
Differentiation Factor

GDF15 (growth-differentiation factor 15) is a novel antihypertrophic factor which is induced in the heart in response to pressure overload and plays an important regulatory role in the process of hypertrophy. In the present study, we have investigated the relationship between GDF15 gene variants and left ventricular hypertrophy in human essential hypertension. A community-based hypertensive population sample of 1527 individuals (506 men and 1021 women) was genotyped for three GDF15 genetic variants, including one tag variant −3148C&gt;G (rs4808793) and two exonic variants +157A&gt;T (rs1059369) and +2438C&gt;G (rs1058587). The effects of those variants on gene expression were studied by use of luciferase reporter assays and the determination of plasma GDF15 levels. Only the tag variant −3148G was significantly associated with a lower risk of left ventricular hypertrophy [odds ratio=0.75 (95% confidence interval, 0.63–0.89); P=0.0009]. Multiple regression analyses confirmed that −3148G predicted the decrease in left ventricular end-diastolic diameter (β=−0.10, P=0.0001), end-systolic diameter (β=−0.09, P=0.0007), mass (β=−0.11, P&lt;0.0001) and indexed mass (β=−0.12, P&lt;0.0001). These effects were independent of conventional factors, including gender, age, body surface area, blood pressure, diabetes, cigarette smoking and alcohol consumption. The transcription activity of the −3148G-containing construct was increased 1.45-fold (P=0.015) at baseline and 1.73-fold (P=0.008) after stimulation with phenylephrine when compared with the −3148C construct. The −3148G allele was also associated with a significant increase in the plasma GDF15 level in hypertensive subjects (P=0.04). In conclusion, the results show that a promoter haplotype containing the −3148G variant increases GDF15 transcription activity and is associated with favourable left ventricular remodelling in human essential hypertension.

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