The Impact of Progressive Visual Field Constriction on Reading Ability in an Inherited Retinal Degeneration

Students grouped as good or poor readers on the basis of a vocabulary test were asked to read a story from a certain perspective or with instructions to read carefully. While the groups given a perspective recalled more information than the control groups, the most interesting results came from the significant interaction of reading ability, reading instruction and type of information. Relative to good readers in the control condition, good readers given a perspective responded with greater recall of information related to the perspective. The poor readers appeared unable or unwilling to use the perspective in differentially processing the perspective relevant sentences.

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Optic Disc Drusen: Longitudinal Aspects, with Emphasis on Visual Field Constriction and Enlarged Blind Spot: A Retrospective Hospital-Based Clinical Series

European Journal of Ophthalmology ◽

10.5301/ejo.5000864 ◽

2016 ◽

Vol 27 (3) ◽

pp. 372-378 ◽

Cited By ~ 2

Author(s):

Hans C. Fledelius

Keyword(s):

Visual Field ◽

Optic Disc ◽

Blind Spot ◽

Observation Time ◽

Main Trend ◽

Visual Field Defects ◽

Optic Disc Drusen ◽

Clinical Series ◽

Field Defects ◽

Visual Field Constriction

Purpose To examine long-term data on optic disc drusen (ODD) from an outpatient hospital series that indicated more cases with advanced visual field constriction than is apparent from other clinical reports. The underlying pathophysiology is discussed, also with regard to enlarged blind spot, which, in view of the small disc at risk, may seem a paradox. Methods This is an observational retrospective study on an eye clinic series (n = 49), focusing on visual acuity, kinetic/static perimetry, and longitudinal trends, to include the question of eventual visual incapacity. Results Forty-nine patients (32 female and 17 male; bilateral ODD in 45) aged 5-76 years (median age 29 years for both sexes) were included in the study. Observation time was 1-54 years, with serial data recorded over at least 3 years in 25 patients. Visual field defects were found in 32 patients, with ODD considered responsible for the visual field defects demonstrated. Advanced unilateral concentric constriction (for the largest Goldmann object) was recorded in 10 patients, and bilaterally in 2. With regard to nonexplanatory side diagnoses, 2 patients had pituitary adenoma, 1 had a cavernous sinus meningioma, and 1 had neurosurgery for an arachnoid cyst. Conclusions We found more cases of marked visual field constriction than reported in other clinical series. A few such cases appeared acute and vascular, but the main trend was clinically quiet over time. All 49 patients could manage visually in daily life.

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Metabolism of the developing retina. 2. The effect of an inherited retinal degeneration on the development of glycolysis in the rat retina*

Biochemical Journal ◽

10.1042/bj0720459 ◽

1959 ◽

Vol 72 (3) ◽

pp. 459-461 ◽

Cited By ~ 14

Author(s):

C. N. Graymore ◽

Katharine Tansley ◽

Margaret Kerly

Keyword(s):

Retinal Degeneration ◽

Rat Retina ◽

Inherited Retinal Degeneration

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Effect of Visual Field Constriction on Visual Search in Orderly Array and Random Array Cancellation Tasks

Psychology ◽

10.4236/psych.2015.614184 ◽

2015 ◽

Vol 06 (14) ◽

pp. 1873-1878 ◽

Cited By ~ 1

Author(s):

Ryotaro Saito ◽

Yoshifumi Ikeda ◽

Hideyuki Okuzumi ◽

Iwao Kobayashi ◽

Mitsuru Kokubun

Keyword(s):

Visual Search ◽

Visual Field ◽

Random Array ◽

Visual Field Constriction

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The impact of wearing single vision soft contact lenses on the peripheral refractive error

F1000Research ◽

10.12688/f1000research.10080.1 ◽

2016 ◽

Vol 5 ◽

pp. 2803

Author(s):

Kareem Allinjawi ◽

Sharanjeet-Kaur Sharanjeet-Kaur ◽

Saadah Mohamed Akhir ◽

Haliza Abdul Mutalib

Keyword(s):

Visual Field ◽

Open Field ◽

Refractive Error ◽

Contact Lens ◽

Contact Lenses ◽

Soft Contact ◽

Soft Contact Lenses ◽

Single Vision ◽

The Right ◽

The Impact

Aim: The purpose of this study was to determine the changes in the relative peripheral refractive error produced by soft single vision contact lenses in myopic schoolchildren. Methods: 27 myopic schoolchildren aged between 13 to 15 years were included in this study. The measurements of central and peripheral refraction were made only on the right eye using a Grand-Seiko WR-5100K open-field autorefractometer without contact lens (WL), and with wearing single vision contact lens (SVCL). Refractive power was measured at center and horizontal eccentricity between 35° temporal to 35° nasal visual field (in 5° steps). Results: SVCL showed an increase in peripheral hyperopic defocus at the nasal and temporal visual field compare with baseline, but this change was not statistically significant (p=0.129). Conclusion: Wearing single vision soft contact lenses increases the relative peripheral hyperopic defocus in myopic schoolchildren.

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The Impact of Reading Ability and Vocabulary at Age 5 and Personal Environment Variables of Children on First Grade Reading Comprehension Ability and Vocabulary

Korean Journal of Child Studies ◽

10.5723/kjcs.2011.32.6.123 ◽

2011 ◽

Vol 32 (6) ◽

pp. 123-139

Author(s):

Ki-Sook Lee ◽

Soon-Hwan Kim ◽

Jong-Won Jeong

Keyword(s):

Reading Comprehension ◽

Reading Ability ◽

First Grade ◽

Environment Variables ◽

Comprehension Ability ◽

The Impact ◽

Reading Comprehension Ability

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Early onset non-syndromic retinal degeneration due to variants in INPP5E: phenotypic expansion of the ciliary gene previously associated with Joubert syndrome

10.1101/2020.08.24.20179085 ◽

2020 ◽

Author(s):

Riccardo Sangermano ◽

Iris Deitch ◽

Virginie G Peter ◽

Rola Ba-Abbad ◽

Emily M Place ◽

...

Keyword(s):

Retinal Degeneration ◽

Early Onset ◽

Joubert Syndrome ◽

Phenotypic Correlation ◽

Cone Dystrophy ◽

Genetic Modifiers ◽

Retinal Degenerations ◽

Pathogenic Variants ◽

Systemic Disorder ◽

The Impact

Purpose: Pathogenic variants in INPP5E cause Joubert syndrome, a systemic disorder that can manifest with retinal degeneration among other clinical features. We aimed to evaluate the role of INPP5E variants in non-syndromic inherited retinal degenerations (IRDs) of varying severity. Methods: Targeted or genome sequencing were performed in 12 unrelated non-syndromic IRD families from multiple research hospitals. Detailed clinical examination was conducted in all probands. The impact of new likely pathogenic variants was modeled on a tertiary INPP5E protein structure and all the new and published variants were analyzed for their deleteriousness and phenotypic correlation. Results: Fourteen INPP5E rare alleles were detected, 12 of which were novel. Retinal degeneration in all 12 probands was clinically distinguishable on the basis of onset and severity into Leber congenital amaurosis (n=4) and a milder, later-onset rod-cone dystrophy (n=8). Two probands showed mild ciliopathy features that resolved in childhood. Analysis of the combined impact of both alleles in syndromic and non-syndromic INPP5E patients did not reveal clear genotype-phenotype correlation, suggesting involvement of genetic modifiers. Conclusions: The study expands the phenotypic spectrum of disorders due to pathogenic variants in INPP5E and describes a new disease association with previously underdiagnosed forms of early-onset non-syndromic IRD.

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