scholarly journals The Effectiveness of Nasal Airway Stent Therapy for the Treatment of Mild-to-Moderate Obstructive Sleep Apnea Syndrome

Respiration ◽  
2020 ◽  
pp. 1-8
Author(s):  
Kengo Ohtsuka ◽  
Rie Baba ◽  
Wakako Yamasawa ◽  
Ryutaro Shirahama ◽  
Yoichiro Hattori ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Sleep Quality ◽  
Quality Index ◽  
Pittsburgh Sleep Quality Index ◽  
Sleep Apnea Syndrome ◽  
Nasal Airway ◽  
Airway Stent ◽  
Obstructive Sleep ◽  
Apnea Syndrome

<b><i>Background:</i></b> Patients with obstructive sleep apnea syndrome (OSAS) experience excessive daytime sleepiness and insomnia and they are at risk of developing cardiovascular disease and stroke. Continuous positive airway pressure therapy could improve symptoms and decrease these risks; however, adherence is problematic. Although the oral appliance is another therapeutic option, patient satisfaction is limited and the effect of the nasal airway stent – a new device – remains unclear. <b><i>Objectives:</i></b> The aim of this study was to evaluate the effect of NAS therapy in patients with mild-to-moderate OSAS in a prospective, single-arm, interventional pilot study. <b><i>Method:</i></b> Patients with mild/moderate sleep apnea (<i>n</i> = 71; Apnea-Hypopnea Index [AHI], 5–20 events/h on polysomnography) were recruited. Sleep-associated events were measured using a portable device (WatchPAT200) pre- and immediately post-treatment and at 1 month follow-up. AHI (including supine and non-supine AHI), Oxygen Desaturation Index (ODI), Respiratory Disturbance Index (RDI), percutaneous oxygen saturation, heart rate, and snore volume were evaluated. Symptoms were assessed using the Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, and Hospital Anxiety and Depression Scale. <b><i>Results:</i></b> NAS use significantly improved AHI, supine AHI, RD, ODI, and snore volume compared to pre-intervention (<i>r</i> = 0.44, 0.48, 0.3, 0.42, and 0.34; <i>p</i> &#x3c; 0.001, <i>p</i> &#x3c; 0.001, <i>p</i> = 0.011, <i>p</i> &#x3c; 0.001, and <i>p</i> = 0.048, respectively). Additionally, 25 and 10% of patients showed complete and partial response for AHI, respectively; these improvements remained significant 1 month later. Pittsburgh Sleep Quality Index scores improved from 6.0 to 5.3 (<i>r</i> = 0.46, <i>p</i> = 0.022). <b><i>Conclusions:</i></b> NAS therapy reduced severity and snoring in patients with mild-to-moderate OSAS. Approximately 30% of patients did not tolerate NAS due to side effects.

Sex-Related Differences in Polygraphic Parameters in a Population of Patients with Obstructive Sleep Apnea Syndrome

2021 ◽  
Vol 20 ◽  
Author(s):  
Laura Buratti ◽  
Chiara Rocchi ◽  
Viviana Totaro ◽  
Serena Broggi ◽  
Simona Lattanzi ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Cardiovascular Risk ◽  
Sleep Apnea ◽  
Sleep Quality ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Men And Women ◽  
Autonomic Changes ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Background: Sex-related differences in the prevalence and clinical presentation of Obstructive Sleep Apnea Syndrome (OSAS) have been widely documented. The aim of this study was to investigate the influence of patients’ sex on polygraphic parameters with particular attention to sleep autonomic changes in a population of OSAS patients. Methods: Sixty OSAS patients aged 55-65 years (30 men, 30 women) were enrolled. Sleep quality was assessed with the Pittsburgh Sleep Quality Index (PSQI) and daytime sleepiness with the Epworth Sleepiness Scale (ESS). The presence of respiratory events and autonomic changes during the night was investigated by polygraphy. Results : Similar main cardiovascular risk factors prevalence was observed in both men and women. We observed a significant difference in PSQI (higher in women, p=0.0001) and ESS (higher in men, p=0.004) scores. Snoring (p=0.033), supine AHI (p=0.004), T90 (p=0.021), LO2 (p=0.0001), LF/HF ratio and LF (p=0.0001) were significantly higher in men. Sex differences in PSQI mean score and LF/HF ratio variability were preserved in all the subgroups of OSA severity. Conclusion: The influence of sex in modulating cardiovascular risk is a widely discussed topic. In our study, men showed more severe polygraphic parameters and an increase in LF/HF ratio compared to women. The results of our investigation suggest the relevance of delivering information about the different expressions of OSAS in men and women in order to improve diagnostic skills and in-depth prevention approaches.

scholarly journals The effect of adherence with long-term PAP therapy on the psycho-emotional state of patients with obstructive sleep apnea syndrome

2020 ◽  
Vol 17 (2) ◽  
pp. 56-60
Author(s):  
E. M. Elfimova ◽  
O. O. Mikhailova ◽  
N. T. Khachatryan ◽  
I V Starostin ◽  
A. Yu. Litvin ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Sleep Quality ◽  
Obstructive Sleep Apnea Syndrome ◽  
Daytime Sleepiness ◽  
Sleep Apnea Syndrome ◽  
Good Adherence ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Aim. To assess the impact of adherence and effectiveness of long-term positive airway pressure therapy (PAP-therapy) on the clinical and psychological characteristics of patients with obstructive sleep apnea syndrome. Materials and methods. The study included 80 patients who were examined in the sleep apnea laboratory of the Myasnikov Institute of Clinical Cardiology of the National Medical Research Center for Cardiology and who have been on PAP-therapy for more than 12 months. The average age of the patients was 65.0 years [59.0; 71.0], body mass index 35.0 kg/m2 [31.0; 38.0], sleep apnea-hypopnea index (AHI) 39.5/h [31.0; 62.6]. The average duration of PAP therapy was 3.5 years [2.0; 6.0], while the minimum use was 1 year, the maximum 15 years. In the sample of patients who came in person, the percentage of days using PAP-therapy was 87.5% [62.0; 98.0] and the average usage time 6.3 hours [5.2; 7.3]. Results. On long-term PAP-therapy a persistent decrease in AHI was seen on average from 39.5/h [31.0; 62.6] to 2.7/h [1.2; 6.2], p=0,000. The criteria for good adherence to PAP-therapy (use 4 hours/night, more than 70% of nights) were met by the percentage of days of use by 67.5% of patients, the average time of use by 87.5% of patients. Both criteria for good adherence to PAP-therapy was met by 64.8% of patients. With long-term PAP-therapy, 71.7% of patients met the criteria of effectiveness (AHI5/h), AHI remained 5/h in 22.9% of patients and the average residual AHI was 10/h in 5.4% of patients. Correlation analysis showed associations between the PAP-therapy usage parameters and the severity of obstructive sleep apnea syndrome, and sleep quality: percentage of days of use and AHI (r=0.374, p=0.001), average time of use and PSQI (r=-0.438, p=0.000). Patients with a lower adherence to PAP-therapy (63.0% of days [22.0; 96.0] and 3.6 hours [2.4; 4.5] of use) did not differ in daytime sleepiness (ESS 5.0 points [2.0; 9.0] and 5.0 points [3.0; 8.0 ], p=0.891), but had a significantly lower quality of sleep (PSQI): 18.0 points [14.0; 20.0] versus 10.0 points [7.0; 18.0], p=0.004 compared with patients with high adherence to PAP-therapy (98.0% of the days [92.0; 99.0] and 7.9 hours [7.5; 8.2] of use). Conclusions. Patients with the higher adherence to PAP-therapy had significantly better sleep quality. But even the use of PAP-therapy for less than 4 hours is associated with a decrease in daytime sleepiness severity.

scholarly journals Hubungan Berat Badan dengan Kualitas Tidur pada Mahasiswa Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Kristen Krida Wacana Angkatan 2016

2020 ◽  
Vol 26 (2) ◽  
Author(s):  
Mohamad Naim Bin Hasan ◽  
William William ◽  
Flora Rumiati
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Sleep Quality ◽  
Quality Index ◽  
Pittsburgh Sleep Quality Index ◽  
Chi Square ◽  
Cross Sectional ◽  
Purposive Sampling ◽  
Obstructive Sleep

Kelebihan berat badan merupakan faktor independen yang berkontribusi terhadap kualitas tidur yang buruk. Sleep apnea merupakan timbulnya episode abnormal pada frekuensi napas yang berhubungan dengan penyempitan saluran napas atas pada saat tidur. Sleep apnea dapat berupa henti napas (apnea) atau menurunnya ventilasi yang akan menyebabkan gangguan bernapas saat tidur. Semakin besar nilai Indeks Massa Tubuh (IMT) atau bertambahnya berat badan, kemungkinan untuk mengalami Obstructive Sleep Apnea (OSA) semakin tinggi. Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara IMT dengan kualitas tidur pada mahasiswa kedokteran angkatan 2016 FKIK Ukrida. Jenis penelitian yang digunakan adalah penelitian cross sectional dengan menggunakan studi komparatif, yaitu untuk mengetahui hubungan antara IMT dengan kualitas tidur pada mahasiswa golongan berat badan lebih dan berat badan normal. Teknik sampling yang digunakan dalam penelitian ini adalah purposive sampling. Sebanyak  88 responden berpartisipasi dalam penelitian ini, terdiri dari 44 mahasiswa yang mempunyai berat badan normal dan 44 mahasiswa yang mempunyai berat badan lebih. Responden mengisi kuesioner Pittsburgh Sleep Quality Index (PSQI).   Hasil penelitian menunjukkan sebanyak 64 responden (72,7%) mempunyai kualitas tidur buruk, dan 24 responden (27,3%) memiliki kualitas tidur yang baik, serta durasi tidur terbanyak adalah < 6 jam.  Berdasarkan uji Chi-Square, disimpulkan adanya hubungan antara berat badan dengan kualitas tidur (p = 0,000, p < 0,05) pada mahasiswa Fakultas Kedokteran angkatan 2016 FKIK Ukrida.

scholarly journals Apolipoprotein E polymorphisms and sleep quality in Obstructive Sleep Apnea Syndrome

2011 ◽  
Vol 412 (23-24) ◽  
pp. 2223-2227 ◽  
Author(s):  
R. Pellegrino ◽  
D.R. Mazzotti ◽  
C. Guindalini ◽  
R. Santos-Silva ◽  
L.R.A. Bittencourt ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Sleep Quality ◽  
Apolipoprotein E ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Obstructive Sleep ◽  
Apnea Syndrome
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