scholarly journals Viruria of Human BK Virus and John Cunningham Virus among Renal Transplant Recipients and Healthy Control in Southeast of Caspian Sea

Intervirology ◽  
2021 ◽  
pp. 1-8
Author(s):  
Fereshteh Safaei ◽  
Alireza Mohebbi ◽  
Mina Hassanpour ◽  
Hadi Razavi Nikoo ◽  
Alijan Tabarraei
Keyword(s):  
Renal Transplant ◽  
Bk Virus ◽  
Control Group ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Genotype I ◽  
The North ◽  
North Of Iran ◽  
Healthy Control ◽  
Genotype Ii

Background: Members of the Polyomaviridae family, BK virus (BKV), and John Cunningham virus (JCV) are linked to polyomavirus-associated nephropathy-associated transplant rejection in immunodeficient patients. Objective: The aim of the study was to evaluate the prevalence of BKV and JCV in immunocompetent individuals in the north of Iran. Methods: Ninety-one urine samples were obtained from renal transplant recipients with a mean age of 39.78 ± 11.19 years. A healthy control group of 65 volunteers with an average age of 40.32 ± 10.7 years also contributed. After DNA extraction, positive cases were detected through PCR. Genotyping was done by alignment and phylogenetic tree construction of the VP1 region against all known JCV and BKV genotypes. Results: The prevalence of BKV and JCV was 15.38 and 19.78%, respectively. JCV was detected in 7.69% of the control group. The prevalence of the BKV between the case and control groups was significant (p < 0.0001). There was no significant association between BKV and JCV and duration of dialysis (p > 0.05). Overall, 62.16% of JCV cases were genotype I. Besides, genotype II was dominant within patients with BKV-positive patients. Discussion: The results obtained here show a relatively lower prevalence of BKV and JCV in immunocompromised renal transplant receivers and healthy control than those reported from other areas in Iran. JCV genotyping was evaluated for the first time in Iran. Genotype I for JCV and genotype II for BKV were dominant genotypes in the north of Iran.

scholarly journals BK polyomavirus genotypes and progression of BKV disease in renal transplant recipients

2020 ◽  
Vol 2 (7A) ◽  
Author(s):  
Nafraa Fallatah
Keyword(s):  
Renal Transplant ◽  
Bk Virus ◽  
Renal Transplant Recipients ◽  
Vp1 Gene ◽  
Transplant Recipients ◽  
Viral Loads ◽  
Acute Graft Rejection ◽  
Bk Polyomavirus ◽  
Genotype Ii ◽  
Acute Graft

Background. BK virus (BKV) reactivation is a significant cause of BK Polyomavirus associated nephropathy (BKPyVN) resulting in acute graft rejection in 1-10% of post-renal transplant recipients. However, the association of BKV genotypes with development of BKPyVN is poorly understood. Here we aimed to determine the prevalence of BKV genotypes in post-renal transplant recipients, and its association with BKPyVN disease progression. Method. Two methods were utilised to genotype BKV. A 800bp fragment of virus VP1 antigen region was amplified using nested (PCR) followed by sequencing. The genotypes were determined according to a previously developed algorithm based on analysing 100bp region of the VP1 gene. Furthermore, the logarithm results were validated with the constructed phylogenetic tree. The results were correlated with patient viral loads and development of BKPyVN. Results. BK virus DNA was detected in 32 (69%) of 46 post-renal transplant recipients with BK viremia, while BKPyVN was only reported in two (4.3%)patients. 30 out of 32 samples were successfully genotyped (93.7%) with 23 (76.6%) belonging to the BKV Ib-2 subtype and seven (23.3%) belonging to the BKV Ib-1 subtype and with no cases representing genotype II, III and IV. All cases with confirmed BKPyVN matched to the BKV Ib-2 genotype. Additionally, no significance differences were observed between BKV genotypes in regards to viral loads, development of viremia, HLA mismatch, age or sex. Conclusion. The results indicate no correlations between BKV genotypes and the development of BKPyVN. Furthermore,a high distribution of BKV genotype Ib-2 was found among BKV infected patients within this cohort.

scholarly journals BK Virus-Specific Antibodies and BKV DNA in Renal Transplant Recipients with BKV Nephritis

2005 ◽  
Vol 5 (11) ◽  
pp. 2719-2724 ◽  
Author(s):  
Sundaram Hariharan ◽  
Eric P. Cohen ◽  
Brahm Vasudev ◽  
Rimas Orentas ◽  
Raphael P. Viscidi ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Bk Virus ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Specific Antibodies

BK virus replication in renal transplant recipients: Analysis of potential risk factors may contribute in reactivation

2017 ◽  
Vol 96 ◽  
pp. 7-11 ◽  
Author(s):  
Mohammad Shenagari ◽  
Ali Monfared ◽  
Hadise Eghtedari ◽  
Aydin Pourkazemi ◽  
Tolou Hasandokht ◽  
...  
Keyword(s):  
Risk Factors ◽  
Renal Transplant ◽  
Virus Replication ◽  
Potential Risk ◽  
Bk Virus ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Potential Risk Factors

scholarly journals Risk factors in the progression of BK virus-associated nephropathy in renal transplant recipients

2015 ◽  
Vol 30 (6) ◽  
pp. 865-872 ◽  
Author(s):  
Hae Min Lee ◽  
In-Ae Jang ◽  
Dongjae Lee ◽  
Eun Jin Kang ◽  
Bum Soon Choi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Renal Transplant ◽  
Bk Virus ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

scholarly journals Prevalence of BK Virus among Iranian Renal Transplant Recipients: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 4 (4) ◽  
pp. 50-61
Author(s):  
Mohsen Ebrahimi ◽  
Alireza Mohebbi ◽  
Mohammad Mostakhdem Hashemi ◽  
Mobina Ashrafi Shahmirzadi ◽  
◽  
...  
Keyword(s):  
Systematic Review ◽  
Renal Transplant ◽  
Meta Analysis ◽  
Bk Virus ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

BK Virus Nephropathy in Renal Transplant Recipients in Kuwait: A Preliminary Report

2005 ◽  
Vol 37 (7) ◽  
pp. 3048-3050 ◽  
Author(s):  
M.R.N. Nampoory ◽  
K.V. Johny ◽  
A. Pacsa ◽  
P.M. Nair ◽  
T. Said ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Preliminary Report ◽  
Bk Virus ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Bk Virus Nephropathy

Diagnosis of Polyoma Virus Infection In Renal Transplant Recipients

1999 ◽  
Vol 5 (S2) ◽  
pp. 1166-1167
Author(s):  
J. A. C. King ◽  
D. N. Howell ◽  
J. A. Tucker ◽  
R. P. Lowry
Keyword(s):  
Renal Transplant ◽  
Virus Infection ◽  
Renal Transplant Patient ◽  
Bk Virus ◽  
Polyoma Virus ◽  
Immunosuppressed Patient ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Immunosuppressed Patients ◽  
Cadaver Kidney

BK polyoma virus is a 40-45 nm DNA virus that was first identified in the urine of an immunosuppressed patient in 1971. BK virus infection often occurs in childhood and is subclinical. The majority of adults have antibodies to the virus. Asymptomatic viruria, ureteral ulceration, and ureteral stenosis have been described with infection in immunosuppressed patients. Renal graft dysfunction and interstitial nephritis have been associated with BK virus. Differentiation between rejection and infection is important. We report a case of a renal transplant patient with BK polyoma virus infection. This case illustrates the variety of methods that can be used for identification of BK polyoma virus.The patient, a 52 year old female, presented with an asymptomatic rise in serum creatinine (1.4 to 2.1 mg/dl). Her past medical history was significant for a cadaver kidney transplant two years prior for polycystic kidney disease.

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