scholarly journals Long-Lasting Complete Remission of Small-Cell Carcinoma of the Pancreas with Carboplatin and Etoposide Complicated by Gallbladder Adenocarcinoma Diagnosed during Follow-Up

2021 ◽  
pp. 365-370
Author(s):  
Konstantinos Tyriakidis ◽  
Sylvia Stadlmann ◽  
Stefanie Pederiva
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Small Cell ◽  
Hematogenous Metastasis ◽  
Treatment Protocols ◽  
Carcinoma Of The Pancreas ◽  
Dismal Prognosis ◽  
Complete Clinical Remission ◽  
Gallbladder Adenocarcinoma

Small-cell carcinoma of the pancreas (PSCC) is a highly aggressive neoplasia with a dismal prognosis. It is extremely rare, with only a few cases reported in the literature. There is a paucity of clinical data to guide management and since the disease is mainly diagnosed at an advanced stage standard treatment consists of chemotherapy based upon treatment protocols used for small-cell lung cancer. We report the case of a female diagnosed with PSCC who achieved complete clinical remission after treatment with carboplatin and etoposide. During a 3-year follow-up the patient developed a gallbladder adenocarcinoma that was treated by surgical resection but relapsed within 20 months with widespread hematogenous metastasis.

scholarly journals Tri-modal management of primary small cell carcinoma of the pancreas (SCCP): a rare neuroendocrine carcinoma (NEC)

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Safa Elzein ◽  
Fei Bao ◽  
Ray Lin ◽  
Gabriel Schnickel ◽  
Andrew M. Lowy ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Neuroendocrine Carcinoma ◽  
Lymphovascular Invasion ◽  
Complete Response ◽  
Small Cell ◽  
Case Presentation ◽  
Carcinoma Of The Pancreas ◽  
Dismal Prognosis ◽  
Multi Agent

Abstract Background Primary small cell carcinoma of the pancreas (SCCP) is a rare malignant neuroendocrine carcinoma (NEC). Typically, it presents with lymphovascular invasion as well as metastasis at the time of diagnosis which portends a dismal prognosis. Treatment is typically based on therapy used for other aggressive NECs such as small cell lung cancer. Although multimodal surgery, radiation and chemotherapy may improve prognosis, the outcome generally remains poor. Case presentation Here we present a primary SCCP managed with neoadjuvant multi-agent chemotherapy combined with radiotherapy and surgery Conclusions Multi-disciplinary therapy resulted in an ongoing 28 + month radiographic complete response and overall survival.

Poorly differentiated small cell carcinoma of the pancreas

Pancreatology ◽  
2004 ◽  
Vol 4 (6) ◽  
pp. 521-526 ◽  
Author(s):  
Simone Berkel ◽  
Frank Hummel ◽  
Jochen Gaa ◽  
Walter Back ◽  
Ralf Hofheinz ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Small Cell ◽  
Carcinoma Of The Pancreas ◽  
Poorly Differentiated

Curative resection of a small cell carcinoma of the pancreas: Report of a case of long survival without chemotherapy

2004 ◽  
Vol 19 (9) ◽  
pp. 1087-1091 ◽  
Author(s):  
KAZUO KINOSHITA ◽  
TAKESHI MINAMI ◽  
YOSHIKAZU OHMORI ◽  
SHUJI KANAYAMA ◽  
KOICHI YOSHIKAWA ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Curative Resection ◽  
Small Cell ◽  
Long Survival ◽  
Carcinoma Of The Pancreas

scholarly journals Distal Humerus as Delayed Site of Metastasis from Small Cell Carcinoma of Gallbladder

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Mutahir A. Tunio ◽  
Mushabbab AlAsiri ◽  
Asma Mohammed F. Ali ◽  
Eyad Fawzi AlSaeed ◽  
Muhammad Shuja ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
World Literature ◽  
Case Reports ◽  
Locally Advanced ◽  
Distal Humerus ◽  
Small Cell ◽  
Rare Entity ◽  
Dismal Prognosis ◽  
Advanced Stages

Background. Small cell carcinoma (SCC) of the gallbladder is a rare entity and is often seen in elderly women. SCC of gallbladder is typically a nonsecretory carcinoid tumor without overt clinical symptoms and is often discovered at advanced stages. SCC of gallbladder carries a dismal prognosis as compared to SCC of lung and adenocarcinoma of gallbladder. To date, only 73 case reports have been published in the world literature.Case Presentation. Herein, we report a case of a 73-year-old Saudi woman who presented with one week history of right upper quadrant abdominal pain and obstructive jaundice and was found to be a case of locally advanced, metastatic SCC of gallbladder cT4N1M1 (liver, para-aortic lymph nodes, and bone). The patient was treated with neoadjuvant etoposide and cisplatin (EP) chemotherapy three cycles after biliary stenting followed by radical cholecystectomy, lymphadenectomy, and adjuvant EP chemotherapy and then one year later developed distal humerus osseous metastasis.Conclusion. SCC of the gallbladder is very rare entity and is often seen at advanced stages. Osseous metastases of peripheral skeleton from SCC gallbladder are rarely reported. Surgery is curative option but only for early stage tumors. Incorporation of chemotherapy along with radical resection increases the survival.

scholarly journals Establishment and Characterization of a New Cell Line, A99, From a Primary Small Cell Carcinoma of the Pancreas

Pancreas ◽  
2011 ◽  
Vol 40 (6) ◽  
pp. 905-910 ◽  
Author(s):  
Shinichi Yachida ◽  
Yi Zhong ◽  
Raul Patrascu ◽  
Meghan B. Davis ◽  
Laura A. Morsberger ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Cell Line ◽  
Small Cell Carcinoma ◽  
Small Cell ◽  
Carcinoma Of The Pancreas ◽  
New Cell Line

Small cell carcinoma of the pancreas: population-based study of a rare tumor using the National Cancer Data Base

2015 ◽  
Vol 221 (4) ◽  
pp. e22
Author(s):  
Tommy Ivanics ◽  
John R. Bergquist ◽  
Christopher Shubert ◽  
Elizabeth B. Habermann ◽  
Rory L. Smoot ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Data Base ◽  
Small Cell Carcinoma ◽  
Population Based ◽  
National Cancer Data Base ◽  
Small Cell ◽  
Rare Tumor ◽  
Population Based Study ◽  
Carcinoma Of The Pancreas ◽  
Cancer Data

scholarly journals A Case of Small Cell Carcinoma of Lung Presenting as Opaque Hemithorax

2020 ◽  
Author(s):  
Keerthan Ganapathi ◽  
Saood Ali ◽  
Ulhas Jadhav ◽  
Babaji Ghewade
Keyword(s):  
Lung Cancer ◽  
Pleural Effusion ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Small Cell ◽  
Tobacco Smoke Exposure ◽  
Opaque Hemithorax ◽  
Contrast Enhanced ◽  
Enhanced Computed Tomography

The most common cause of an Opaque Hemithorax is Pleural Effusion. It is a rare occurrence to find patients with extensive mass leading to an opaque hemithorax. Thorough search of literature did not yield any case with such a large lung mass leading to opaque hemithorax, without the presence of pleural effusion. Lung cancer is the most common cancer diagnosed worldwide and has predominantly been attributed to tobacco smoke exposure. Of the several types, small cell lung cancer differs from others by its early spread and extensive dissemination leading to metastatic classification at the time of diagnosis. Here, is a case of a 50-year-old female patient who presented to the outpatient department with dry cough, weight loss and appetite loss since five months. Her chest radiograph revealed a right-sided homogeneous opacity involving the entire right hemithorax and left-sided pleural-based homogenous mass. Contrast Enhanced Computed Tomography (CECT) thorax revealed an enlarged hemithorax with evidence of large, ill-defined heterogeneously enhancing multilobulated soft-tissue density mass lesion occupying the entire right hemithorax. Biopsy was suggestive of Small Cell Carcinoma of Lung (SCLC), chemotherapy was given and patient is under regular follow-up.

Sign in / Sign up

Export Citation Format

Share Document