scholarly journals Deep Brain Stimulation for Post-Traumatic Stress Disorder: A Review of the Experimental and Clinical Literature

2022 ◽  
pp. 1-13
Author(s):  
Jennifer Meeres ◽  
Marwan Hariz
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Combat Veterans ◽  
Stress Disorder ◽  
Post Traumatic Stress ◽  
Rat Models ◽  
Post Traumatic ◽  
Deep Brain

<b><i>Introduction:</i></b> Up to 30% of patients with post-traumatic stress disorder (PTSD), especially combat veterans, remain refractory to conventional treatment. For them, deep brain stimulation (DBS) has been suggested. Here, we review the literature on animal models of PTSD in which DBS has been used to treat PTSD-type behavior, and we review and discuss patient reports of DBS for PTSD. <b><i>Methods:</i></b> A broad search was performed to find experimental animal articles and clinical reports on PubMed, Ovid MEDLINE, Cochrane Library, and PsycINFO, using combinations and variations of search words pertinent to DBS and PTSD. <b><i>Results:</i></b> The search yielded 30 articles, 24 on DBS in rat models of PTSD, and 6 publications between 2016 and 2020 reporting on a total of 3 patients. DBS in rat models targeted 4 brain areas: medial prefrontal cortex (mPFC), ventral striatum, amygdala, and hippocampus. Clinical publications reported on 2 male combat veterans who received DBS in basolateral amygdala, and 1 female with PTSD due to domestic abuse, who received DBS of mPFC. All 3 patients benefitted to various extents from DBS, at follow-ups of 4 years, 6 months, and 7 months, respectively. <b><i>Conclusions:</i></b> PTSD is the only potential clinical indication for DBS that shows extensive animal research <i>prior</i> to human applications. Nevertheless, DBS for PTSD remains highly investigational. Despite several years of government funding of DBS research in view of treating severe PTSD in combat veterans, ethical dilemmas, recruitment difficulties, and issues related to use of DBS in such a complex and heterogenous disorder remain prevalent.

Amygdala deep brain stimulation for combat post-traumatic stress disorder

2015 ◽  
Vol 8 (2) ◽  
pp. 312 ◽  
Author(s):  
Ralph J. Koek ◽  
Jean-Philippe Langevin ◽  
Scottt E. Krahl ◽  
Holly N. Schwartz ◽  
James WY. Chen ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Post Traumatic Stress ◽  
Post Traumatic ◽  
Deep Brain

Post-traumatic stress disorder and risk for suicide in combat veterans

2021 ◽  
pp. 269-274
Author(s):  
Herbert Hendin
Keyword(s):  
At Risk ◽  
Military Personnel ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Psychodynamic Psychotherapy ◽  
Combat Veterans ◽  
Stress Disorder ◽  
Post Traumatic Stress ◽  
Post Traumatic ◽  
Not At Risk

Post-traumatic stress disorder (PTSD) is a condition associated with suicide in both military personnel and combat veterans. Most veterans with PTSD, however, are not at risk of suicide. The major factor distinguishing those who attempted or were preoccupied with suicide is persistent severe guilt over behaviour in combat while emotionally out of control. A 12-session short-term, psychodynamic psychotherapy, presented here in this chapter, showed promise of success in dissipating the guilt from combat-related actions in veterans of the war in Vietnam. Preliminary work with combat veterans of the wars in Iraq and Afghanistan indicates it may be equally successful in treating them.

scholarly journals Neuromodulation Strategies in Post-Traumatic Stress Disorder: From Preclinical Models to Clinical Applications

2019 ◽  
Vol 9 (2) ◽  
pp. 45 ◽  
Author(s):  
Flavia Gouveia ◽  
Darryl Gidyk ◽  
Peter Giacobbe ◽  
Enoch Ng ◽  
Ying Meng ◽  
...  
Keyword(s):  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Post Traumatic Stress ◽  
Adequate Response ◽  
Lifetime Prevalence Rate ◽  
Post Traumatic ◽  
Fear And Anxiety ◽  
Deep Brain

Post-traumatic stress disorder (PTSD) is an often debilitating disease with a lifetime prevalence rate between 5–8%. In war veterans, these numbers are even higher, reaching approximately 10% to 25%. Although most patients benefit from the use of medications and psychotherapy, approximately 20% to 30% do not have an adequate response to conventional treatments. Neuromodulation strategies have been investigated for various psychiatric disorders with promising results, and may represent an important treatment option for individuals with difficult-to-treat forms of PTSD. We review the relevant neurocircuitry and preclinical stimulation studies in models of fear and anxiety, as well as clinical data on the use of transcranial direct current stimulation (tDCS), repetitive transcranial magnetic stimulation (rTMS), and deep brain stimulation (DBS) for the treatment of PTSD.

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