Amygdala deep brain stimulation for combat post-traumatic stress disorder

2015 ◽  
Vol 8 (2) ◽  
pp. 312 ◽  
Author(s):  
Ralph J. Koek ◽  
Jean-Philippe Langevin ◽  
Scottt E. Krahl ◽  
Holly N. Schwartz ◽  
James WY. Chen ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Post Traumatic Stress ◽  
Post Traumatic ◽  
Deep Brain

scholarly journals Deep Brain Stimulation for Post-Traumatic Stress Disorder: A Review of the Experimental and Clinical Literature

2022 ◽  
pp. 1-13
Author(s):  
Jennifer Meeres ◽  
Marwan Hariz
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Combat Veterans ◽  
Stress Disorder ◽  
Post Traumatic Stress ◽  
Rat Models ◽  
Post Traumatic ◽  
Deep Brain

<b><i>Introduction:</i></b> Up to 30% of patients with post-traumatic stress disorder (PTSD), especially combat veterans, remain refractory to conventional treatment. For them, deep brain stimulation (DBS) has been suggested. Here, we review the literature on animal models of PTSD in which DBS has been used to treat PTSD-type behavior, and we review and discuss patient reports of DBS for PTSD. <b><i>Methods:</i></b> A broad search was performed to find experimental animal articles and clinical reports on PubMed, Ovid MEDLINE, Cochrane Library, and PsycINFO, using combinations and variations of search words pertinent to DBS and PTSD. <b><i>Results:</i></b> The search yielded 30 articles, 24 on DBS in rat models of PTSD, and 6 publications between 2016 and 2020 reporting on a total of 3 patients. DBS in rat models targeted 4 brain areas: medial prefrontal cortex (mPFC), ventral striatum, amygdala, and hippocampus. Clinical publications reported on 2 male combat veterans who received DBS in basolateral amygdala, and 1 female with PTSD due to domestic abuse, who received DBS of mPFC. All 3 patients benefitted to various extents from DBS, at follow-ups of 4 years, 6 months, and 7 months, respectively. <b><i>Conclusions:</i></b> PTSD is the only potential clinical indication for DBS that shows extensive animal research <i>prior</i> to human applications. Nevertheless, DBS for PTSD remains highly investigational. Despite several years of government funding of DBS research in view of treating severe PTSD in combat veterans, ethical dilemmas, recruitment difficulties, and issues related to use of DBS in such a complex and heterogenous disorder remain prevalent.

scholarly journals Neuromodulation Strategies in Post-Traumatic Stress Disorder: From Preclinical Models to Clinical Applications

2019 ◽  
Vol 9 (2) ◽  
pp. 45 ◽  
Author(s):  
Flavia Gouveia ◽  
Darryl Gidyk ◽  
Peter Giacobbe ◽  
Enoch Ng ◽  
Ying Meng ◽  
...  
Keyword(s):  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Post Traumatic Stress ◽  
Adequate Response ◽  
Lifetime Prevalence Rate ◽  
Post Traumatic ◽  
Fear And Anxiety ◽  
Deep Brain

Post-traumatic stress disorder (PTSD) is an often debilitating disease with a lifetime prevalence rate between 5–8%. In war veterans, these numbers are even higher, reaching approximately 10% to 25%. Although most patients benefit from the use of medications and psychotherapy, approximately 20% to 30% do not have an adequate response to conventional treatments. Neuromodulation strategies have been investigated for various psychiatric disorders with promising results, and may represent an important treatment option for individuals with difficult-to-treat forms of PTSD. We review the relevant neurocircuitry and preclinical stimulation studies in models of fear and anxiety, as well as clinical data on the use of transcranial direct current stimulation (tDCS), repetitive transcranial magnetic stimulation (rTMS), and deep brain stimulation (DBS) for the treatment of PTSD.

scholarly journals DBS in Treatment of Post-Traumatic Stress Disorder

2017 ◽  
Author(s):  
Angelo Lavano ◽  
Giusy Guzzi ◽  
Attilio Della Torre ◽  
Serena Marianna Lavano ◽  
Raffaele Tiriolo ◽  
...  
Keyword(s):  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Pharmacological Therapy ◽  
Post Traumatic Stress ◽  
Randomized Controlled Studies ◽  
Post Traumatic ◽  
Preclinical And Clinical Studies ◽  
Deep Brain

Background: Post-traumatic stress disorder (PTSD) is a common debilitating psychiatric condition for which pharmacological therapy is not always solvable. Various treatments have been suggested for these patients. Deep brain stimulation (DBS) is currently under investigation for patients affected by PTSD. 2) Methods: We review the neurocircuitry and up to date clinical concepts that may be of relevance for the implementation of DBS in posttraumatic stress disorder (PTSD). 3) Results: The role of DBS in treatment-refractory PTSD patients has been investigated relying on both preclinical and clinical studies. 4) Conclusions: DBS for PTSD is in its preliminary phases and likely to provide hope to patients with medical refractory PTSD following the results of randomized controlled studies.

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