Efficacy of Curcuminoids in managing postoperative pain after total laparoscopic hysterectomy: A randomized controlled, open-label trial.

2022 ◽  
Author(s):  
Chai Ariyasriwatana ◽  
Natacha Phoolcharoen ◽  
Shina Oranratanaphan ◽  
Pongkasem Worasethsin
Keyword(s):  
Postoperative Pain ◽  
Visual Analog Scale ◽  
Curcuma Longa ◽  
Laparoscopic Hysterectomy ◽  
Control Group ◽  
Analog Scale ◽  
Open Label ◽  
Vas Scores ◽  
The Mean ◽  
Experimental Group

Background and aims: Curcuminoids, which are substances extracted from turmeric (Curcuma longa), have anti-inflammatory and analgesic effects and a good safety profile. This study aimed to evaluate the clinical efficacy of curcuminoid extracts on reducing pain among patients who underwent laparoscopic hysterectomy. Experimental procedure: From November 2016 to December 2017, 98 participants were included in this clinical trial, and they were randomly assigned to the experimental and control arms according to blocks of four. The intraoperative findings did not significantly differ between the two groups. The experimental group received one tablet of curcuminoid extract 250 mg four times a day on postoperative days 1–3. Pain was evaluated at 24 and 72 h postoperatively using a 10-point visual analog scale (VAS). Results and conclusion: The mean visual analog scale (VAS) scores at 24 h after surgery were 4.9 in the experimental group and 4.3 in the control group. Hence, the results did not significantly differ (p = 0.129). The mean VAS scores at 72 h after surgery were 1.8 in the experimental group and 2.8 in the control group (p = 0.001). The side effects in both groups were similar. Hence, curcuminoids can be an effective supplement for reducing pain after laparoscopic hysterectomy. The conclusion from this study is, that curcuminoids may be an effective supplement to reduce postoperative pain following laparoscopic hysterectomy.

scholarly journals EFFICACY AND SAFETY OF CURCUMA LONGA EXTRACT IN THE TREATMENT OF OSTEOARTHRITIS: A SYSTEMATIC REVIEW

2019 ◽  
pp. 140-145
Author(s):  
ALESSA FAHIRA ◽  
ALLYSA SORAYA ◽  
ARMAND ACHMADSYAH ◽  
RANI WARDANI HAKIM
Keyword(s):  
Adverse Effects ◽  
Randomized Controlled Trials ◽  
Visual Analog Scale ◽  
Curcuma Longa ◽  
Control Group ◽  
Controlled Trials ◽  
Analog Scale ◽  
Randomized Controlled ◽  
Natural Remedies

Objective: Osteoarthritis (OA) is a chronic disease caused by inflammation of the tissue and bony structure of the joint, which affects more than 235 million people worldwide. Due to the adverse effects caused by the long-term use of standard treatment of OA, the attempt to find natural remedies to treat chronic diseases continues to rise. Curcuma longa is known to have anti-inflammatory effects, which may impact the pathophysiology of OA. While many randomized controlled trials show the efficacy of Curcuma longa extract in the treatment of OA, there has been no comprehensive review of this evidence. Methods: We systematically searched PubMed, Cochrane, Scopus, ProQuest, EBSCOhost, and ScienceDirect for randomized controlled trials that evaluated Curcuma longa extract (CE extract) vs. control (placebo or other therapy). Three trials were identified. Data were then extracted from the studies and summarized descriptively. Results: Across all trials, Curcuma longa therapy was proven to reduce Visual Analog Scale (VAS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores significantly compared to the control group. Adverse effects were less likely to appear in patients treated with Curcuma longa extract compared to other groups. Conclusion: CL extract is beneficial as an alternative medication for OA treatment, shown by the reduced scores of the Visual Analog Scale (VAS) and WOMAC in all studies we reviewed.

Efficacy of the Morphine-Adcon-L Compound in the Management of Postoperative Pain after Lumbar Microdiscectomy

Neurosurgery ◽  
2002 ◽  
Vol 50 (3) ◽  
pp. 518-525 ◽  
Author(s):  
Luciano Mastronardi ◽  
Marco Pappagallo ◽  
Fabrizio Puzzilli ◽  
Carlo Tatta
Keyword(s):  
Postoperative Pain ◽  
Visual Analog Scale ◽  
Pain Control ◽  
Control Group ◽  
Postoperative Pain Control ◽  
Analog Scale ◽  
Work Time ◽  
Long Term Outcome ◽  
Lumbar Microdiscectomy ◽  
Straight Leg Raising

Abstract OBJECTIVE: Epidural analgesia is a pharmacological technique for operative and postoperative pain control. It has been used with lumbar microdiscectomy to facilitate management of surgical pain, shorten patient recovery time, and increase patient satisfaction with the procedure and the hospital stay. Adcon-L (Gliatech, Inc., Cleveland, OH) (adhesion control in a barrier gel) has been demonstrated to act as a barrier to the development of epidural fibrosis after lumbar procedures, minimizing the formation of fibrotic scar and improving the long-term outcome. In this study, we used Adcon-L as a vehicle to administer 1 mg of morphine epidurally to patients who underwent lumbar microdiscectomy. Our objective was to evaluate the safety and analgesic efficacy of this compound . METHODS: A randomized, controlled, double-blind study was conducted in 100 patients. Patients were randomized to two groups: the morphine-Adcon-L (M-ADL) group (n = 51 patients) or the Adcon-L control group (n = 49 patients). Outcome measures included: 1) a visual analog scale to assess the intensity of spontaneous low back and radicular pain, 2) a straight leg-raising maneuver to assess the degree of leg elevation in relation to evoked sciatic pain, 3) postoperative time to comfortable walking, 4) duration of postoperative hospitalization, 5) required amount of postoperative analgesics, and 6) postoperative work time loss. RESULTS: No intraoperative or postoperative complications were observed. No clinically relevant adverse events, such as urinary retention, respiratory disturbances, or wound infections were reported in the M-ADL group. At the time of hospital discharge, results were as follows: 1) the M-ADL group had significantly lower pain intensity scores (mean value of postoperative visual analog scale, 12.3 mm ± 0.9 in the M-ADL group versus 24.7 mm ± 11.5 in the control group [P < 0.0001]); 2) the M-ADL group consumed significantly less analgesics: 57.4% of M-ADL patients versus 95.9% of controls received analgesics in the hospital, and 23.5% of M-ADL patients versus 55.1% of controls used analgesics at home (P < 0.0001); 3) the M-ADL group had significantly shorter hospital stays (1.37 ± 0.07 d versus 2.53 ± 0.12 d in the control group [P < 0.0001]); 4) the M-ADL group had a significantly higher degree of symptomatic leg elevation in the straight leg raising (mean postoperative straight leg-raising test, 64.41 degrees ± 1.59 versus 57.77 degrees ± 1.85 in the controls [P = 0.02]); and 5) the M-ADL group lost significantly less postoperative work time (21.67 ± 0.92 d versus 29.47 ± 1.18 d in the control group). In addition, at 1 year of follow-up, there was no clinical evidence of late-onset neurological complications. CONCLUSION: The epidural application of the compound M-ADL after lumbar microdiscectomy was found to be safe and effective, and it significantly improved postoperative pain control and return to function.

scholarly journals INTRAPERITONEAL USING OF BUPIVАCAIN FOR THE ANESTHESIA OF PATIENTS AFTER LAPAROSCOPIC CHOLECYSTECTOMY

2018 ◽  
Vol 14 (1-2) ◽  
pp. 54-58
Author(s):  
F.S. Glumcher ◽  
S.O. Solyaryk ◽  
O.V. Oliynyk ◽  
A.I. Kolosovych
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Visual Analog Scale ◽  
Surgical Intervention ◽  
Intraperitoneal Administration ◽  
Control Group ◽  
Average Dose ◽  
Analog Scale ◽  
Pain Evaluation ◽  
The Mean ◽  
Group 1

Relevance. The local anesthetics were used intraperitoneally after some minimally invasive gynecological interventions like a component of postoperative multimodal anesthesia in recent years.   Objective. The aim of  work was to study the effectiveness of intraperitoneal administration  of bupivokain  for the anesthesia of patients after laparoscopic cholecystectomy. Material and methods. 28 patients aged 32-60 years  (16 women, 12 men) were examined. The patients were divided into two groups. In the first group for anesthesia after the operation, was used ketorolac trometamine in dose 0.2 mg/kg intramuscularly each 6 hours. If the patient complained of postoperative pain, which was assessed by Visual-analog scale in 7 points or higher, fentanyl was administered intramuscularly in dose of 0.003 μg/kg. In the second group, besides the components of multimodal anesthesia used in the first group, at the end of the surgical intervention at the drainage tubes were injected 40 ml of 0.125% solution of bupivocaine (50 mg). This injection was repeated throughout the first day each 6 hours. The condition of patients was assessed by a Visual-analog scale after 1, 4, 8, 12 and 24 hours after the finishing of surgery. The average dose of fentanyl in μg/kg used for postoperative anesthesia  first 24 hours after operation was also determined. Results.  We have received a significant reduction in the rates of pain evaluation for Visual-analog scale in patients who used bupivacaine as a component of multimodal anesthesia. One hour after the end of the operation, the pain score for Visual-analog scale was less than the corresponding one in the control group in 1.77 times, after 4 hours – in 1.47, and in 8 hours – in 1.55 times. In all cases, P <0.001. The mean dose of fentanyl used for treatment in the study group was 1.55 times less than that in the control group. There were no significant complications in both groups. A patient in group 1 had nausea, requiring a single dose of ondasetron 2 mg Conclusion. Intraperitoneal administration of bupivocaine had a significant  anesthetic effect after laparoscopic cholecystectomy.

Comparing the Effectiveness of Intra-Articular Injection of Bupivacaine, Dexmedetomidine Vs. 0.9% Saline on Pain Control after Arthroscopic Anterior Cruciate Ligament Reconstruction

2020 ◽  
Author(s):  
Mohammadreza Minator Sajjadi ◽  
Reza Zandi ◽  
Mohammad Ali Okhovatpour ◽  
Pooyan Jalalpour ◽  
Mohammadreza Moshari
Keyword(s):  
Anterior Cruciate Ligament ◽  
Postoperative Pain ◽  
Acl Reconstruction ◽  
Cruciate Ligament ◽  
Postoperative Pain Management ◽  
Control Group ◽  
Saline Administration ◽  
Vas Scores ◽  
The Mean ◽  
Anterior Cruciate

Background: In different ways, drugs are administered to reduce postoperative analgesia after arthroscopic anterior cruciate ligament (ACL) reconstruction. The purpose of this study is to compare the dexmedetomidine (DEX) intra-articular injection with bupivacaine hydrochloride and sterile 0.9% saline administration following arthroscopic ACL reconstruction.   Methods: Sixty cases who underwent ACL reconstruction were randomly divided into three groups. The first group received intra-articular DEX; the second group received intra-articular bupivacaine, and the final group received intra-articular 0.9% saline. Postoperative pain was measured by Visual Analogue Scale (VAS).   Results: The mean VAS scores at 6 and 24 hours after surgery were lower in the bupivacaine group, compared to the other groups. Pain was more severe in the control group (0.9% saline), with higher VAS scores reported at 1, 6, and 24 hours after surgery.   Conclusions:  Bupivacaine has more significant effects than  DEX  in postoperative pain management after arthroscopic ACL reconstruction.

scholarly journals INTRAPERITONEAL USING OF BUPIVАCAIN FOR THE ANESTHESIA OF PATIENTS AFTER LAPAROSCOPIC CHOLECYSTECTOMY

2018 ◽  
Vol 14 (1-2) ◽  
pp. 54-58
Author(s):  
F.S. Glumcher ◽  
S.O. Solyaryk ◽  
O.V. Oliynyk ◽  
A.I. Kolosovych
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Visual Analog Scale ◽  
Surgical Intervention ◽  
Intraperitoneal Administration ◽  
Control Group ◽  
Average Dose ◽  
Analog Scale ◽  
Pain Evaluation ◽  
The Mean ◽  
Group 1

Relevance. The local anesthetics were used intraperitoneally after some minimally invasive gynecological interventions like a component of postoperative multimodal anesthesia in recent years.   Objective. The aim of  work was to study the effectiveness of intraperitoneal administration  of bupivokain  for the anesthesia of patients after laparoscopic cholecystectomy. Material and methods. 28 patients aged 32-60 years  (16 women, 12 men) were examined. The patients were divided into two groups. In the first group for anesthesia after the operation, was used ketorolac trometamine in dose 0.2 mg/kg intramuscularly each 6 hours. If the patient complained of postoperative pain, which was assessed by Visual-analog scale in 7 points or higher, fentanyl was administered intramuscularly in dose of 0.003 μg/kg. In the second group, besides the components of multimodal anesthesia used in the first group, at the end of the surgical intervention at the drainage tubes were injected 40 ml of 0.125% solution of bupivocaine (50 mg). This injection was repeated throughout the first day each 6 hours. The condition of patients was assessed by a Visual-analog scale after 1, 4, 8, 12 and 24 hours after the finishing of surgery. The average dose of fentanyl in μg/kg used for postoperative anesthesia  first 24 hours after operation was also determined. Results.  We have received a significant reduction in the rates of pain evaluation for Visual-analog scale in patients who used bupivacaine as a component of multimodal anesthesia. One hour after the end of the operation, the pain score for Visual-analog scale was less than the corresponding one in the control group in 1.77 times, after 4 hours – in 1.47, and in 8 hours – in 1.55 times. In all cases, P <0.001. The mean dose of fentanyl used for treatment in the study group was 1.55 times less than that in the control group. There were no significant complications in both groups. A patient in group 1 had nausea, requiring a single dose of ondasetron 2 mg Conclusion. Intraperitoneal administration of bupivocaine had a significant  anesthetic effect after laparoscopic cholecystectomy.

scholarly journals The Reliability of Remembered Pretreatment Visual Analog Scale Scores among Hand-Surgery Patients

2019 ◽  
Vol 12 (01) ◽  
pp. 08-12
Author(s):  
Vilhjalmur Finsen ◽  
Sigrun Hillesund ◽  
Ida Fromreide
Keyword(s):  
Visual Analog Scale ◽  
Hand Surgery ◽  
Analog Scale ◽  
Vas Score ◽  
Upper Limits ◽  
Scale Scores ◽  
Vas Scores ◽  
The Mean ◽  
Individual Scores ◽  
Preoperative Score

Abstract Background In clinical audits in which preoperative visual analog scale (VAS) scores were not recorded, it would be useful if such scores could be re-created at the time of review. Patients and Methods We recorded VAS score for pain during the past week before surgery for 245 consecutive hand-surgery patients scheduled for planned surgery during a 6-month period. A total of 30 patients who refused to participate or were unable to respond were excluded. The remaining 215 patients were contacted after 21 months and asked to furnish a new VAS score of the pain they remembered to have had during the last week before surgery. Responses were analyzed with a Bland-Altman plot. Results One hundred and thirty-one (61%) of the patients responded. The mean remembered preoperative score was higher than the mean real preoperative score in all diagnosis groups. The mean difference was 10 mm (standard deviation: 22 mm; standard error of the mean: 2 mm). The lower and upper limits of 95% agreement for individual scores were -33 and 53 mm, whereas the lower and upper limits of the 95% confidence interval of the mean were 6 and 14 mm. Conclusion It may be possible to predict the mean real preoperative VAS score in groups of patients with accuracy using the remembered preoperative score. In individual patients, remembered preoperative VAS scores are far too inaccurate to be of value. However, real preoperative scores should be used whenever possible.

The effect of acupuncture on pain score after open kidney surgery

2015 ◽  
Vol 12 (3) ◽  
Author(s):  
Kamiar Tavakkoli Tabassi ◽  
Parisa Amini ◽  
Shabnam Mohammadi ◽  
Rahim Taghavi Razavizadeh ◽  
Amir Golchian
Keyword(s):  
Clinical Trial ◽  
Pain Score ◽  
Visual Analog Scale ◽  
Acupuncture Group ◽  
Control Group ◽  
Analog Scale ◽  
Gender And Age ◽  
The Mean ◽  
Spss Software ◽  
Scale Data

Abstract: The pain after nephrectomy, just as any other surgery, is one of the problems that surgeons confront. The aim of this study was to evaluate the relieving effect of acupuncture on the pain experienced after nephrectomy.: This was a clinical trial that was performed on 30 patients with mean age of 40.8 ± 12.54 who were candidates for nephrectomy. After matching for gender and age, the patients were divided into either acupuncture or control group. In acupuncture group, four points were stimulated for 30 minutes, and in control group, other points were stimulated ineffectively for 30 min. Then, the pain experienced in the first six hours after the surgery was registered by a blind observer based on visual analog scale. Data were analyzed using SPSS software and the t-test.: Our results showed that the severity of pain in the acupuncture group was significantly lower than that in the control group. Also, there were six patients who required opioids in the acupuncture group, but there were 12 such patients in the control group. The mean opiate used in the control group was significantly greater than the mean for the acupuncture group.: Acupuncture can reduce the severity of pain and the demand for opioids in patients who have undergone nephrectomy.

scholarly journals Sacroplasty: A Ten-Year Analysis of Prospective Patients Treated with Percutaneous Sacroplasty: Literature Review and Technical Considerations

2017 ◽  
Vol 7 (20;7) ◽  
pp. E1063-E1072
Author(s):  
Christopher Warner
Keyword(s):  
Patient Satisfaction ◽  
Control Group ◽  
Post Procedure ◽  
Vas Scores ◽  
The Mean ◽  
Pre Treatment ◽  
Experimental Group ◽  
Analgesic Use

Background: The treatment of sacral fractures has evolved since its first description in 1982. Several techniques for sacral augmentation have been developed since 2001, and the rate of improvement is rapid with over 50% reduction in pain achieved prior to post-procedure discharge of the patient. Pain reduction occurs primarily within the first 3 months and is sustained at 12 months; however, the long-term outcomes have not previously been studied. Objectives: We aim to evaluate the long-term efficacy of sacroplasty versus non-surgical management (NSM) in treating sacral insufficiency fractures (SIFs), including the effect on pain relief, opioid and other analgesic use, patient satisfaction, and complication rates. Additionally, we aim to review the most current sacroplasty literature. Study Design: A 10-year prospective, observational cohort study of patients with SIFs treated with sacral augmentation. Setting: A single-center interventional pain management private practice. Methods: Two-hundred and forty-four patients with SIFs were treated with sacroplasty (210 patients) or NSM (34 patients) beginning in January 2004 and then followed for 10 years. The patients’ gender, age, pre-procedure pain duration, analgesic use, pain level, and satisfaction were recorded at baseline and at post-procedure follow-up intervals of 2, 4, 12, 24, 52 weeks, and 2 years. The experimental group was then contacted at 10 years. Post-procedure complications before discharge and at each follow-up were also evaluated. Results: Both NSM and sacroplasty resulted in statistically significant drops in visual analog scale (VAS) scores from pre-treatment to 2-year follow-up (P < 0.001). When measured from followup to follow-up, the NSM group’s only significant decrease in the mean VAS score was between pre-treatment and 2 weeks (P = 0.002). The experimental group had significant decreases over the periods pre-op through post-op (P < 0.001), post-op through 2 weeks (P < 0.001), 12 weeks through 24 weeks (P = 0.014), and 24 weeks through one year (P = 0.002). The experimental cohort experienced statistically significant drops in the mean VAS scores between follow-ups for a longer period of time. Opioid and non-opioid analgesic use was markedly decreased preoperatively to postoperatively and was sustained at the 10-year follow-up. Limitations: Patients were placed into the control group, NSM, if they did not meet inclusion criteria for sacroplasty. However, the baseline characteristics of the sacroplasty versus NSM group were not statistically different. Additionally, the control group was only followed through 2 years and was not contacted at the 10-year follow-up. Conclusions: Our results and those reported in previous studies establish that sacroplasty allows for decreased use of medications and results in pain relief, greater patient mobility, and improved patient satisfaction. In addition to the published body of literature, our results show strong evidence in support of sacroplasty as a safe and efficacious treatment of SIFs. Key words: Sacroplasty, sacral fracture, fracture, osteoporosis, insufficiency, radiology

Rorschach Characteristics in Adolescents with Systemic Lupus Erythematosus

2006 ◽  
Vol 28 (1) ◽  
pp. 100-118 ◽  
Author(s):  
J. Santoantonio ◽  
L. Yazigi ◽  
E. I. Sato
Keyword(s):  
Lupus Erythematosus ◽  
Case Control Study ◽  
Activity Index ◽  
Disease Activity Index ◽  
Female Adolescents ◽  
Control Group ◽  
Intelligence Scale ◽  
The Mean ◽  
Experimental Group ◽  
Control Study

The purpose of this study was to investigate the personality characteristics in adolescents with SLE. The research design is a case-control study by means of the Rorschach Method and the Wechsler Intelligence Scale. Study group: 30 female adolescents with lupus, 12–17 years of age. The SLE Disease Activity Index was administered during the period of psychological evaluation. Control group: 32 nonpatient adolescents were matched for age, sex, and socioeconomic level. In the Wechsler Intelligence Scale the mean IQ of the experimental group was significantly lower than that of the control group (77 and 98, respectively, p < .001). In the Rorschach, the lupus patients showed greater difficulty in interpersonal interactions, although they displayed the resources to process affect and to cope with stressful situations. A positive moderate correlation (p = .069) between the activity index of the disease and the affect constriction proportion of the Rorschach was observed: the higher the SLEDAI score, the lower the capacity to process affect. There is a negative correlation between the activity index of the disease and the IQ (p = .001): with a higher activity index of the disease, less intellectual resources are available.

scholarly journals The Impact of Game-Based, Modeling, and Collaborative Learning Methods on the Achievements, Motivations, and Visual Mathematical Literacy Perceptions

SAGE Open ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 215824402110035
Author(s):  
Aziz İlhan
Keyword(s):  
Collaborative Learning ◽  
Control Group ◽  
Conventional Instruction ◽  
Game Based Learning ◽  
Mathematical Literacy ◽  
Learning Methods ◽  
Learning Groups ◽  
The Mean ◽  
The Impact ◽  
Experimental Group

The present study aimed to investigate the effects of geometry instruction activities conducted in nature based on modeling, game-based, and cooperative learning methods on achievement, mathematical motivation, and visual mathematical literacy perceptions of third-grade elementary school students. The present study is a quantitative study conducted with a pre-test/post-test experimental design with a control group. The study was conducted with 61 students (35 students in the experimental group and 26 students in the control group). Modeling-, game-, and collaborative learning-based activities were conducted with the students in the experimental group. It was determined that the achievements of students who were instructed with modeling-based activities in geometry were high when compared to that of the students instructed with collaborative learning- and game-based methods, and those in the control group where no intervention was applied. This group was followed by the game-based and collaborative learning groups. Based on the variable of motivation, the mean motivation of the students in the modeling group was higher when compared to that of the students in the collaborative learning, game-based, and conventional instruction groups. This group was followed by the collaborative and game-based learning groups. Also, based on the visual mathematical literacy perception variable, the mean visual mathematics literacy perception of the students in the collaborative learning group was higher when compared to that of the students in the groups where the modeling, game-based, and conventional instruction methods were used. This group was followed by the modeling and game-based learning groups.

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